Effect of polymorphisms in the Slc11a1 coding region on resistance to brucellosis by macrophages in vitro and after challenge in two Bos breeds (Blanco Orejinegro and Zebu)

Martínez, Rodrigo; Dunner, S.; Toro, R.; Tobón, J.; Gallego, J.; Cañón, Javier

doi:10.1590/s1415-47572010000300014

Cited by 25 publications

(16 citation statements)

References 27 publications

(40 reference statements)

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“…Differences between Zebu (B. taurus indicus) and European (B. taurus taurus) cattle in terms of natural resistance to diseases have also been reported (Martínez et al, 2010;Macêdo, 2012); however, whether these cattle differ in their peripheral blood leukocyte profiles is unclear, although this may account for the more efficient immunity observed in some breeds. Importantly, some evidence suggests that peripheral blood leukocytes from Zebu may respond differently than cells from European breeds when stimulated (Turni et al, 2002).…”

Section: Discussionmentioning

confidence: 94%

Comparative phenotypic profile of subpopulations of peripheral blood leukocytes in European (Bos taurus taurus) and Zebu cattle (Bos taurus indicus)

Macêdo

Marciano²,

Rocha³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Differences in cellular and humoral immunity in Zebu (Bos taurus indicus) and European (B. taurus taurus) cattle breeds, which may be related to differences in resistance or susceptibility to infectious or parasitic diseases, are largely unknown. This study aimed to perform a comparative analysis of innate and adaptive immunity of European (including Holstein, Brown Swiss, and Hereford) and Zebu (including Gir, Nelore, and Guzera) breeds, by assessing their peripheral blood leukocyte profiles (i.e., monocytes, eosinophils, and lymphocytes, including CD4 + and CD8 + T cells, and CD21 + B cells). Phenotypic profile of peripheral blood bovine leukocytesHigher frequencies of cells involved in innate immunity were observed in Zebu breeds, particularly monocytes and non-T and non-B cells (13.37 ± 0.9058 and 37.67 ± 1.55, respectively). This finding may contribute to the increased resistance of B. taurus indicus to certain infectious and parasitic diseases. Considering other leukocyte populations in the peripheral blood, among-breed variation was greater than differences between the two subspecies. This study will serve as a basis for further investigations regarding comparative immunology and resistance to infectious and parasitic diseases of cattle.

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Section: Discussionmentioning

confidence: 94%

Comparative phenotypic profile of subpopulations of peripheral blood leukocytes in European (Bos taurus taurus) and Zebu cattle (Bos taurus indicus)

Macêdo

Marciano²,

Rocha³

et al. 2013

Genet. Mol. Res.

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“…However, mortality and morbidity of this livestock species due to infection by intracellular pathogens cause significant economic losses. Resistance to disease is a particularly important attribute of livestock in low‐input production systems in the tropics and developing countries and is often the critical factor in the sustainability of such systems (Martinez et al ., ). There are programmes that exploit selective breeding for disease‐resistant/tolerant genotypes as a new approach to control intracellular infections.…”

Section: Discussionmentioning

confidence: 97%

“…Recent literatures on cattle (Martinez et al ., ; Paixao et al ., ) and buffalo (Borriello et al ., ; Crisa et al ., ) have attempted to associate with the polymorphic microsatellite located in the 3′untranslated region (3′UTR) of the gene. The 3′UTR region in Slc11a1 of cattle has no significant association with resistance to brucellosis in vivo (Paixao et al ., ), and this is in contrary in vitro (Martinez et al ., ). Meanwhile, polymorphism in 3′UTR region in Slc11a1 of buffalo is associated with resistance to brucellosis.…”

Section: Discussionmentioning

confidence: 99%

“…Nramp gene is long known to confer resistance or susceptibility to intracellular pathogens such as Mycobacterium (Gros et al ., ; Mingala et al ., ), Salmonella (Lissner et al ., ), Brucella (Borriello et al ., ; Capparelli et al ., ; Martinez et al ., ; Paixao et al ., ) and Leishmania . These microbial pathogens cause losses to livestock industry worldwide and are transmissible to human population despite the widespread application of antimicrobials and vaccination.…”

Section: Introductionmentioning

confidence: 99%

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Molecular comparison of Slc11a1 and Slc11a2 genes of swamp‐ and riverine‐type water buffaloes

Padiernos

Mingala

2016

Int J Immunogenetics

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Solute-linked carrier 11a and 11a2 (Slc) have been associated with disease resistance and/or susceptibility across animal species. These genes have an important mechanism in the regulation against intracellular infection. This study analysed the genetic characteristic of Slc 11a and 11a2 in swamp-type and riverine-type water buffaloes to understand their immunological distinction. Characterization of Slc11a1 and Slc11a2 genes from swamp- and riverine-type water buffaloes was carried out by molecular cloning, sequencing and phylogenetic analysis. The cloned cDNA of Slc11a1 and Slc11a2 contained an open reading frame of 1647 and 1723 nucleotides, encoding 549 and 574 amino acids, respectively. Nucleotide sequence homology of both Slc11a1 and Slc11a2 had 99% in swamp and riverine type, which gives almost identical polypeptide. However, Slc11a1 and Slc11a2 have substitutions of 5 and 1 amino acid residues, correspondingly. These substitutions suggest as a potential gene markers for resistance and/or susceptibility to intracellular infection. Furthermore, phylogenetic analysis confirmed the degree of relationship between the bubaline species and justifies the distinctness of each breed by the bootstrap value generated.

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“…Although resistance or susceptibility to disease involves multifactorial mechanisms, it has been reported that Zebu cattle tend to have a higher degree of natural resistance to diseases when compared to European cattle [ 27 - 31 ]. Analyzing the profile of peripheral blood leukocytes of different bovine breeds, we recently demonstrated that Guzerat cattle comparatively has increased levels of circulating leukocytes, especially monocytes, eosinophils, T lymphocytes (particularly CD4 + T cells) and non-B/non-T (NTNB) lymphocytes, with a decreased percentage of B lymphocytes, and consequent increase in the T/B and CD4 + /CD8 + ratio [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Influence of endogamy and mitochondrial DNA on immunological parameters in cattle

et al. 2014

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BackgroundEndogamy increases the risk of manifestation of deleterious recessive genes. Mitochondrial DNA allows the separation of American Zebu (Bos indicus and Bos taurus) and evaluate the effect of mitochondrial DNA on productive traits of cattle. However, the effect of endogamy and mitochondrial DNA (mtDNA) on the immune system remains unclear. The aim of this study was to evaluate the association between endogamy, mtDNA and immune parameters.ResultsA total of 86 cattle (43 cows and 43 calves) were used in this study. Age, endogamy, milk yield, and origin of mtDNA were measured and their influence on immunological parameters was evaluated. Older cows had increased CD4+ T cells, decreased CD21+ and γδhigh T cells as well as increased CD4+/CD8+ and T/B ratio. Multiple regression analysis indicated that endogamy in calves was associated with increased CD8+ T and CD21+ B lymphocytes, and decreased γδhigh T cells in peripheral blood. Cows with medium and lower endogamy had a lower percentage of B lymphocytes and γδlow T cells and cows with lower endogamy had higher levels of γδ T cells and γδhigh T cells, as well as the CD4+/CD48+ cell ratio. Calves with higher endogamy had higher levels of CD8+ T lymphocytes, whereas calves with lower endogamy had lower levels of γδlow T cells.ConclusionsThese results demonstrated for the first time that endogamy influences the immune system of cattle.

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Effect of polymorphisms in the Slc11a1 coding region on resistance to brucellosis by macrophages in vitro and after challenge in two Bos breeds (Blanco Orejinegro and Zebu)

Cited by 25 publications

References 27 publications

Comparative phenotypic profile of subpopulations of peripheral blood leukocytes in European (Bos taurus taurus) and Zebu cattle (Bos taurus indicus)

Comparative phenotypic profile of subpopulations of peripheral blood leukocytes in European (Bos taurus taurus) and Zebu cattle (Bos taurus indicus)

Molecular comparison of Slc11a1 and Slc11a2 genes of swamp‐ and riverine‐type water buffaloes

Influence of endogamy and mitochondrial DNA on immunological parameters in cattle

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