Persica chewing gum effects on saliva fluoride concentration and flow rate: A triple-blind randomized clinical trial

Mortazavi, Seyed Bagher; Aslani, Abolfazl; Babaee, Mehrnoush; Hajiahmadi, Maryam

doi:10.4103/ccd.ccd_509_18

Cited by 4 publications

(3 citation statements)

References 21 publications

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“…Moreover, effect of chewing persica [miswak] as antibacterial was proved by many studies. For example, chewing persica containing gum liberated fluoride ions in saliva and increased saliva flow rate comparable with NaF chewing gum use as a gold standard ( Mortazavi et al, 2019 ). Also, addition of chlorhexidine and miswak extract to conventional glass ionomer has good impact on its clinical performance and antibacterial properties as proved by an in vivo study by ( Kabil et al, 2017 ).…”

Section: Health Benefits Of the Plant And Its Extractsmentioning

confidence: 99%

Salvadora persica L.: Toothbrush tree with health benefits and industrial applications – An updated evidence-based review

Farag

Abdel‐Mageed

Gamal

et al. 2021

Saudi Pharmaceutical Journal

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Salvadora persica L. is also known as Arak (in Arabic) and Peelu (in Urdu). Its frequent use as a toothbrush (miswak) is highly recommended by Prophet Muhammad. With a long history in folk medicine for centuries, S. persica was used in oral hygiene, food, cosmetics, fuel, and even as a medicine. Previous phytochemical investigation of its different parts afforded different classes of secondary metabolites such as flavonoids, glycosides, sterols, terpenes, carbohydrates and alkaloids. Organic sulfur-containing compounds and elemental sulfur are also present. In addition, there is a huge research on its biological potentials and industrial applications. Many pharmacological activities were reported experimentally, including antimicrobial, antioxidant, analgesic, anthelmintic, anti-inflammatory, antiulcer, sedative, anticonvulsant, anti-osteoporosis, antidiabetic, hypo-lipidemic, in addition to wound-healing, antidepressant and antitumor activities. Recently, a possible activity against COVID-19 protease was documented by molecular docking. This review tries to provide a recent detailed documentation of folk and modern uses of S. persica, focusing on the possible relations between its chemical constituents, pharmacological properties, and industrial applications. Moreover, a brief about recent analytical and validation methods for the major antimicrobial component is reported.

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Section: Health Benefits Of the Plant And Its Extractsmentioning

confidence: 99%

Salvadora persica L.: Toothbrush tree with health benefits and industrial applications – An updated evidence-based review

Farag

Abdel‐Mageed

Gamal

et al. 2021

Saudi Pharmaceutical Journal

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“…The second point concerns the chewing stick, called “ Miswak ,” which is widely used in some Arab states of the Persian Gulf ( 74 , 75 ). In fact, it seems that “ Miswak ” use increases SFR ( 76 ). The third point concerns the hydration status.…”

Section: Discussionmentioning

confidence: 99%

The Impacts of Ramadan Intermittent Fasting on Saliva Flow-Rate and Metabolic Data: A Systematic Review

et al. 2022

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The aim of this systematic review was to report the impacts of Ramadan intermittent fasting (RIF) on salivary flow-rate (SFR) and metabolic parameters. A thorough literature search was carried out using the databases PubMed and Scopus from their inception up to 15 July 2021. The Boolean connectors used in PubMed were (Saliva [Mesh] AND Fasting [Mesh]). The same keywords were used in Scopus. Inclusion criteria were defined using PICOS. The research included all original studies involving “healthy” adults and published in English. Methodological quality assessment was performed utilizing the Joanna Briggs Institute Critical Appraisal Tool, which allows attributing scores from 1 to 11 to the selected studies. Two authors carried out the literature search, study selection, and data extraction. Differences on issues were resolved by a third author if necessary. The systematic review protocol was registered within the “Open Science Framework” (Doi: 10.17605/OSF.IO/DE7BH). Six articles met the inclusion criteria. All studies were heterogeneous and had a high score of bias and several methodological differences. The following parameters were collected: SFR, melatonin, cortisol, glucose, immunoglobulin A (IgA), uric-acid, alkaline phosphatase (ALP), and aspartate aminotransferase (AST). The SFR decreased by 10% during Ramadan in fasting subjects. The circadian pattern of melatonin remained unchanged during Ramadan, but melatonin levels dropped significantly from baseline. The salivary cortisol levels were unchanged or increased during Ramadan. The salivary glucose levels were decreased. ALP increased significantly, whilst uric-acid and AST decreased significantly. Salivary IgA decreased during the last week of Ramadan. To conclude, there is a trend toward a decrease in SFR and the content of the majority of the biomarkers investigated, with the exception of ALP and uric-acid. These changes cannot be easily attributed to any single factor (hydration status, dietary habits, physical activity, or hygiene habits).Systematic Review Registration: [https://osf.io/de7bh/], identifier [Doi: 10.17605/OSF.IO/DE7B].

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“…The Phyto-Chemical analysis reported that ethanolic miswak extract contains a wide variety of chemicals that ranges in polarity from polar to non-polar compounds (14) . Miswak was reported to release calcium and fluoride that, inhibit enamel demineralization (9) . GSE mouthwash (6.5%) was prepared for its reported anticariogenic properties (5) .…”

Section: Discussionmentioning

confidence: 99%

The Anticariogenic Effect of Miswak (Silvadora Persica) and Grape Seed Extract

Khoriba¹,

Niazy²,

Sharkawy³

2022

ADJ-for Girls

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Purpose: To evaluate the effect of Miswak and Grape seed extract (GSE) on enamel and dentine subjected to artificial acid challenge in-vitro. Materials and Methods: A total of thirty sound freshly extracted sound human permanent periodontally affected upper molars were used. 30 enamel specimens were cut from the buccal surface of the teeth and 30 dentin specimens were cut from the cervical root area. All specimens were polished to obtain a flat polished surface. Ethanolic miswak extract was prepared by percolation method. Solutions of 10% ethanolic miswak extract, 6.5% Grape seed extract and 0.05% sodium fluoride were prepared. Specimens were divided into two groups (n=30); enamel and dentin. Each group was further divided into three sub-groups (n=10) according to the material used. Group1; treated with 10% ethanolic miswak extract solution. Group2; treated with 6.5% GSE solution. Group3; treated with 0.05% sodium fluoride solution (positive control). Specimens were individually subjected to alternative treatment/pH cycling regimen for 7 days. Radiodensity (change in mineral content) for each enamel and dentine specimen was assessed before and after pH cycling using digital radiography. Data were statistically analyzed; the significance level was set at p ≤0.05. Results: Miswak and GSE showed a high percent gain in enamel and dentine radiodensity compared to fluoride. Conclusion: Miswak and GSE are beneficial to both enamel and dentin through increasing their resistance to acid attacks.

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Persica chewing gum effects on saliva fluoride concentration and flow rate: A triple-blind randomized clinical trial

Cited by 4 publications

References 21 publications

Salvadora persica L.: Toothbrush tree with health benefits and industrial applications – An updated evidence-based review

Salvadora persica L.: Toothbrush tree with health benefits and industrial applications – An updated evidence-based review

The Impacts of Ramadan Intermittent Fasting on Saliva Flow-Rate and Metabolic Data: A Systematic Review

The Anticariogenic Effect of Miswak (Silvadora Persica) and Grape Seed Extract

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