Introduction, the global data shows HIV/AIDS infected in the young group, more than 1,4 million the young group infected with this disease, ages more than 15 years old. The highest number of HIV/AIDS in the young period was caused by risky sexual behavior and lack of knowledge, attitude, and practice. This research aims to know the perception of the Z generation as a part of the young period. The method of this research uses a qualitative research design with the generation as an informant, with HBM (Health Believe Model) as a construct theory to explore the Z generation perceived to relate the HIV/AIDS transmission, the informant selected by purposive sampling with inclusion criteria such as the ages in the Z generations (born in years 1996 to 2010). The data will be analyzed with Miles and Huberman. The result shows the Z generation has a perceived susceptibility to HIV/AIDS diseases, and they perceived the seriousness if they got the disease, and they have perceived benefits if they can prevent this disease. However, they have several barriers to prevention activities, such as they did not have role model, they have perception there are few materials relate to prevention HIV/AIDS and they have self-efficacy to do HIV/AIDS prevention. Need to complete the facility to access the information in the school and university to give information related to HIV/AIDS prevention.