Peroxisome proliferator‐activated receptor‐gamma Pro12Ala polymorphism, Helicobacter pylori infection and non‐cardia gastric carcinoma in Chinese

Abstract

SUMMARY BackgroundPeroxisome proliferator-activated receptor c inhibits the growth and induces apoptosis of gastric cancer cells. A common polymorphism at codon 12 of this gene (Pro12Ala) has been shown to confer protection against diabetes and colorectal cancer.

PPAR-Gamma Pro12Ala Polymorphism and Gastric Cancer Risk in a Turkish Population

“…Indeed, GC risk was found to be increased in Ala12 allele carriers of PPARγ gene in the presence of H.pylori infection in previous studies (Liao et al, 2006;Prasad et al, 2008). Further analysis in GC patients with presence of H.pylori infection seems to be mandatory to clarify the association between H.pylori infection and PPARγ polymorphism in GC development.…”

“…We found that the patients with Ala12 allele carriers had 1.57-fold (95%CI: 1.103-2.238) increased risk of progression to GC. Regarding the association between Ala 12 polymorphism of PPAR γ gene and GC risk, Liao et al (2006) reported 2.5-fold increased risk in Chinese, Prasad et al (2008) reported 2.14-fold increased risk in Indian, and Tahara et al (2008). reported 2.4-fold increased risk in Japanese population of progression to GC.…”

“…Genomic DNA was extracted from peripheral whole blood according to salting-out technique (Miller et al, 1998). Genotyping was performed by polymerase chain reaction (PCR) and restriction fragment length polymorphism the procedures of PCR-RFLP are given in Table 1 (Liao et al, 2006). The appropriate primers were used to amplify the corresponding gene of the subjects by PCR and the reaction products were digested by using the appropriate enzyme at 60°C.…”

“…The role of Pro12Ala polymorphism of PPAR γ gene has been recently studied in cancers. Individuals with the Ala12 allele are found to have an increased risk of GC in Chinese (Liao et al, 2006), Indian (Prasad et al, 2008) and Japanese (Tahara et al, 2008) populations. As PPARγ Pro12Ala polymorphism is found to be associated with GC risk we examined the potential association between Pro12Ala polymorphism in the PPARγ gene and GC in Turkish population…”

PPARγ polymorphisms and cancer risk: A meta-analysis involving 32,138 subjects

“…Two PPARÁ common polymorphisms, a C➝G transition in exon B resulting in a proline to alanine exchange at amino acid position 12 (P12A) (OMIM *0002; rs1801282) and a C➝T transition at position 161 in exon 6 (C161T) (OMIM *0009; rs3856806) have been identified and found to be associated with the risk of type 2 diabetes and cardiovascular events (4,5). In recent years evidence shows that both variations may also influence individual susceptibility to several types of cancer, such as those that occur in the central nervous system (6), lung (7,8), stomach (9)(10)(11)(12), biliary tract (13), colorectum (14)(15)(16)(17)(18)(19)(20)(21)(22), bladder (23), breast (24)(25)(26)(27), ovaries (28), endometrium (29), prostate (30)(31)(32), kidney (28) and skin (33). However, the observed results of these studies were inconsistent.…”