PPAR-Gamma Pro12Ala Polymorphism and Gastric Cancer Risk in a Turkish Population

Abstract

Background: Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand dependent transcription factor involved in various processes, including carcinogenesis. We aimed to investigate any possible association of the PPARγ Pro12Ala (rs1801282) polymorphism with risk of developing gastric cancer (GC). Patients and Methods: A hospital based case control study was designed covering 50 patients with GC and 120 healthy controls. The frequencies of PPARγ Pro12Ala (rs1801282) were determined using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. Results: The Ala12 allele of the PPARγ Pro12Ala G gene was associated with a 1.95 fold increased risk of GC development (p: 0.022; 95% CI: 1.58-2.40). Subgroup analyses showed that the same allele was also associated with metastasis (p: 0.000; OR:4.09; 95%CI:2.273-7.368) and differentiation (p: 0.004; OR:1.95; 95%CI:1.335-2.875) in patients with GC. Conclusion: This study suggests that the PPARγ Pro12Ala G (Ala12) allele might be associated with development, differentiation and metastatic process of GC in the Turkish population. Further studies conducted in larger study groups and in different ethnic populations will be needed to clarify the exact role of the PPARγ Pro12Ala polymorphism in GC.

Genotyping of Peroxisome Proliferator-Activated Receptor gamma in Iranian Patients with Helicobacter pylori Infection

“…As mentioned, PPARγ as a host gene plays important role in H. pylori-associated gastric carcinogenesis and (LIAO et al, 2006;Canbay et al, 2012). In our study, frequency of GG genotype and GC genotype were 33.7% and 40.8%, respectively.…”

Peroxisome Proliferator-Activated Receptor-Gamma Pro12Ala Polymorphism Could be a Risk Factor for Gastric Cancer

“…One article was excluded for repeat studies based on the same population (Liao et al, 2007). Finally, a total of 5 case-control studies (Liao et al, 2006;Prasad et al, 2008;Tahara et al, 2008;Bazargani et al, 2010;Canbay et al, 2012) including 546 cases and 827 controls were identified for further analysis. There were 2 studies of Asians (Liao et al, 2006;Tahara et al, 2008), 3 of Caucasians (Prasad et al, 2008;Bazargani et al, 2010;Canbay et al, 2012).…”

“…However, other similar observations could not draw such conclusion in prostate cancer (Paltoo et al, 2003;Zmuda et al, 2006), lung cancer (Campa et al, 2004), endometrial cancer (Paynter et al, 2004) and ovarian cancer (Pinheiro et al, 2010). On the contrary, recent studies found that Pro12Ala polymorphism increased the risk of gastric cancer (Canbay et al, 2012). Although there have been several studies investigating this Pro12Ala polymorphism with gastric cancer risk, due to the small sample size of the each study, it is not sufficient to form a reliable conclusion, so, we performed a meta-analysis to investigate these associations.…”

Systems Pharmacology and Microbiome Dissection of Shen Ling Bai Zhu San Reveal Multiscale Treatment Strategy for IBD

“…Deletion of KLF5 can result in a decrease in PI3K/AKT signaling and accumulate HIF1 α in prostate tumors to promote tumor angiogenesis [40]. Previous research has illustrated that the PPAR γ allele may be involved in the development, differentiation, and metastasis of gastric cancer in Turkey [43]. Sphk1 has been shown to be involved in the pathogenesis of human hepatocellular carcinoma (HCC), and DMS can inhibit the effects of Sphk1.…”