Peroxisomal protein import pores

Meinecke, Michael; Bartsch, Philipp; Wagner, Richard

doi:10.1016/j.bbamcr.2015.10.013

Cited by 31 publications

(32 citation statements)

References 123 publications

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“…The first derives from the idea that most peroxisomal proteins might be imported into peroxisomes after oligomerization in the cytosol. Since some of these oligomers expose several PTSs on their surface, they might interact with several PEX5 molecules and be presented to the DTM as such . However, as discussed above, peroxisomal import of already oligomerized cargoes may not be that frequent.…”

Section: Assembling the Syringe − Interaction Of Cargo‐loaded Receptomentioning

confidence: 99%

Protein transport into peroxisomes: Knowns and unknowns

et al. 2017

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Peroxisomal matrix proteins are synthesized on cytosolic ribosomes and rapidly transported into the organelle by a complex machinery. The data gathered in recent years suggest that this machinery operates through a syringe-like mechanism, in which the shuttling receptor PEX5 - the "plunger" - pushes a newly synthesized protein all the way through a peroxisomal transmembrane protein complex - the "barrel" - into the matrix of the organelle. Notably, insertion of cargo-loaded receptor into the "barrel" is an ATP-independent process, whereas extraction of the receptor back into the cytosol requires its monoubiquitination and the action of ATP-dependent mechanoenzymes. Here, we review the main data behind this model.

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Section: Assembling the Syringe − Interaction Of Cargo‐loaded Receptomentioning

confidence: 99%

Protein transport into peroxisomes: Knowns and unknowns

et al. 2017

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“…Such a flexible, dynamic pore exists in the thylakoid membrane and is formed by single‐TM domain containing Tat components . Likewise, a dynamic pore accommodates entry of fully folded proteins into the peroxisome matrix …”

Section: What Are the Characteristics Of The New Channels In The Omm?mentioning

confidence: 99%

Novel Channels of the Outer Membrane of Mitochondria: Recent Discoveries Change Our View

Checchetto

Szabó

2018

BioEssays

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Ion channels mediate ion flux across biological membranes and regulate important organellar and cellular tasks. A recent study revealed the presence of four new proteins, the MIM complex (composed by Mim1 and Mim2), Ayr1, OMC7, and OMC8, that are able to form ion-conducting channels in the outer mitochondria membrane (OMM). These findings strongly indicate that the OMM is endowed with many solute-specific channels, in addition to porins and known channels mediating protein import into mitochondria. These solute-specific channels provide essential pathways for the controlled transport of ions and metabolites and may thus add a further layer of specificity to the regulation of mitochondrial function at the organelle-cytosol and/or inter-organellar interface. Future studies will be required to fully understand the way(s) of regulation of these new channels and to integrate them into signaling pathways within the cells.

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“…Pex19p is an oleic acid-inducible protein with a farnesyl group added, which is vital for peroxisome biogenesis. The lacking Pexp19 result in the absence of peroxisome and mislocalization of peroxisomal matrix proteins to the cytosol (Meinecke et al 2016).…”

Section: Peroxisomes -Power To Virusesmentioning

confidence: 99%

Killing two birds with one stone: How do Plant Viruses Break Down Plant Defenses and Manipulate Cellular Processes to Replicate Themselves?

Souza

Carvalho

2019

J. Plant Biol.

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As simple organisms with a parasite nature, viruses have become masters in manipulating and subvert cellular components, including host proteins and organelles, to improve viral replication. Therefore, the understanding of viral strategies to manipulate cell function disrupting plant defenses and enhancing viral infection cycles is fundamental to the production of virus-resistant plant lines. After invading susceptible plants, viruses create conditions that favor local and systemic infections by suppressing multiple layers of innate host defenses while use cellular machinery to own benefit. Viral interference in interlinked essential cellular functions results in phenotypic changes and disease symptoms, which debilitates plants favoring infection establishment. Herein in this review, the novelty it will be the discussion about the strategies used by (+) single strand RNA viruses to affect cellular processes and components to improve viral replication, in parallel to overcome plant defenses, favoring disease establishment by applying in one action using the same viral protein to coordinate viral replication and breaking down plant defense. This focus on plant-virus interaction was never done before, and this knowledge has the potential to help in the development of new strategies to produce resistant plants.

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Peroxisomal protein import pores

Cited by 31 publications

References 123 publications

Protein transport into peroxisomes: Knowns and unknowns

Protein transport into peroxisomes: Knowns and unknowns

Novel Channels of the Outer Membrane of Mitochondria: Recent Discoveries Change Our View

Killing two birds with one stone: How do Plant Viruses Break Down Plant Defenses and Manipulate Cellular Processes to Replicate Themselves?

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