Peroxidase levels in food: relevance to colorectal cancer screening

Caligiore, Paul; Macrae, Finlay; John, David; Rayner, Lauren; Legge, J W

doi:10.1093/ajcn/35.6.1487

Cited by 34 publications

(11 citation statements)

References 10 publications

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“…Thus, FIT is more specific for human blood than guaiac-based tests, which rely on detection of peroxidase in human blood and also react to the peroxidase that is present in dietary constituents such as rare red meat, cruciferous vegetables, and some fruits. 53 Further, unlike gFOBT, FIT is not subject to false-negative results in the presence of high-dose vitamin C supplements, which block the peroxidase reaction. In addition, because globin is degraded by digestive enzymes in the upper gastrointestinal tract, FIT also are more specific for lower gastrointestinal bleeding, thus improving their specificity for CRC.…”

Section: Fitmentioning

confidence: 99%

Screening and Surveillance for the Early Detection of Colorectal Cancer and Adenomatous Polyps, 2008: A Joint Guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology

Levin

Lieberman

McFarland

et al. 2008

CA: A Cancer Journal for Clinicians

1,559

916

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In the United States, colorectal cancer (CRC) is the third most common cancer diagnosed among men and women and the second leading cause of death from cancer. CRC largely can be prevented by the detection and removal of adenomatous polyps, and survival is significantly better when CRC is diagnosed while still localized. In 2006 to 2007, the American Cancer Society, the US Multi Society Task Force on Colorectal Cancer, and the American College of Radiology came together to develop consensus guidelines for the detection of adenomatous polyps and CRC in asymptomatic average-risk adults. In this update of each organization's guidelines, screening tests are grouped into those that primarily detect cancer early and those that can detect cancer early and also can detect adenomatous polyps, thus providing a greater potential for prevention through polypectomy. When possible, clinicians should make patients aware of the full range of screening options, but at a minimum they should be prepared to offer patients a choice between a screening test that is effective at both early cancer detection and cancer prevention through the detection and removal of polyps and a screening test that primarily is effective at early cancer detection. It is the strong opinion of these 3 organizations that colon cancer prevention should be the primary goal of screening. (CA Cancer J Clin 2008;58:130-160.)

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Section: Fitmentioning

confidence: 99%

Screening and Surveillance for the Early Detection of Colorectal Cancer and Adenomatous Polyps, 2008: A Joint Guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology

Levin

Lieberman

McFarland

et al. 2008

CA: A Cancer Journal for Clinicians

1,559

916

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“…The majority of countries that had implemented the CRC programme at the time of our pilot study used guaiac-based FOBT (Caligiore et al, 1982;Castiglione et al, 1996;Denis et al, 2004;Désirée 2007;Guittet et al, 2009) and proved a 16% reduction in death rate due to CRC. Updated results of the Minnesota trial through 18 years of follow-up reported a 21% reduction in CRC mortality in the biennial screening group, whereas the reduction in CRC mortality in the annual screening remained at 33% (Mandel et al, 1999).…”

Section: Discussionmentioning

confidence: 84%

“…Because we knew that the faecal immunochemical test (FIT) for human haemoglobin offers better sensitivity and specificity than guaiac-based tests and simplifies the entire sampling process, we decided to use FIT. It does not involve any dietary restrictions (Caligiore et al, 1982), which increases the compliance rate. FIT provides quantitative faecal haemoglobin measurements and different cutoff values can be set according to the national endoscopic capacities (Smith et al, 2006;Désirée, 2007;Van Rossum et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Faecal immunochemical test-based colorectal cancer screening programme SVIT in Slovenia

Tepeš¹,

Štabuc²,

Stefanović

et al. 2014

European Journal of Cancer Prevention

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Colorectal cancer (CRC) is the second most common cancer in Slovenia. The 5-year survival of patients depends on the clinical stage at presentation. More than 70% of patients with CRC are diagnosed as being in stage III or IV, with a 5-year survival rate of 52.7%. To improve the detection rate of CRC and to detect CRC in its early and more curable stage, a national screening programme is needed. In the year 2008, we started a pilot phase of the National CRC screening programme. We invited 9091 Slovene residents aged 64-68 years from Ljubljana, Kranj, and Celje regions, of whom 3807 responded to our invitation (41.9%). Two kits of the faecal immune test were sent to 3117 participants who met the inclusion criteria, and 2829 (90.7%) tests were returned. The compliance rate in our pilot programme was 32.9%. Among the patients who responded positively, 7.5% were positive. Until February 2009, 193 colonoscopies had been performed at DC Bled, DC Lipa and AM DC Rogaška. Intubation to the caecum was carried out in 99.4% of colonoscopies. Histology specimens were taken from 135 patients (70%). The adenoma detection rate was 53.8% (59.8% for men and 47.9% for women; P<0.05). We detected 1-17 adenomas per patient (2.4 on average). Advanced adenomas were detected in 60 patients (31%; 35.1% of men and 27.1% of women; P<0.05). Invasive carcinoma was detected in 15 patients (7.7%; 12.4% of men and 3.1% of women; P<0.05). Ten of them (73.3%) were in clinical stage I or II. In the pilot phase of the CRC screening programme the majority of CRCs were detected at early clinical stages. Invasive cancers were detected in 7.7% of patients. In almost all patients adenomas were resected at screening colonoscopy, thus reducing the possibility of later development of CRC in those patients.

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“…Although a chemical method is the most widely used FOB diagnostic method nowadays, such an approach still suffers from its labor‐cost (or non‐automatic capability) and unreliability due to certain interference in subjects who are on unrestricted diets. Interference resulting from certain medicinal drugs with peroxidase‐active components such as iodine, boric acid, aspirin, non‐steroidal anti‐inflammatory steroids, anticoagulants, and large doses of iron preparations often results in crucial false‐positive diagnoses by guaiac‐based FOB tests 11–13. Certain foods containing high levels of heme/Hb (e.g., rice cakes mixed with mammal/poultry blood or red meat) may also cause false‐positive results 14.…”

mentioning

confidence: 99%

“…turnips and horseradish), is also a problem 15–17. False‐negative results are caused by large doses of vitamin C 13. In addition, several of the chromogens commonly employed in conventional chemical assays (e.g., benzidine, o ‐tolidine, and diethyl‐ p ‐phenylenediamine) are carcinogenic and unstable during storage 18…”

mentioning

confidence: 99%

Matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry for the detection of hemoglobins as the protein biomarkers for fecal occult blood

Lin

Shih

et al. 2007

Rapid Comm Mass Spectrometry

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In this study, we discover that hemoglobins (Hb), highly water-soluble globular proteins that are the most predominant proteins detected by matrix-assisted laser desorption ionization/time-of-flight (MALDI-TOF) mass spectrometry in blood, can be used as protein biomarkers for fecal occult blood (FOB). Hemoglobins were extracted from the feces with pure water and separated from the solids in feces through centrifugation. Singly charged molecular ions of Hb-related alpha chains (theoretical MW: 15 126) and beta chains (theoretical MW: 15 867) were detected by MALDI-TOF operated in linear mode using 4-hydroxy-alpha-cyanocinnamic acid (alpha-CHC) as the matrix (with a volumetric ratio of 1:1). The detection limit of FOB using this method is estimated to be lower than 0.1 microg blood per mg of feces, which is approximately 10 to 100 times lower than that of the conventional chemical approaches. The foods and dietary supplements that commonly interfere with the conventional chemical assays of FOB - such as animal blood food products and tablets containing iron and vitamin C - do not interfere with the detection of Hb biomarkers during MALDI-TOF analysis.

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Peroxidase levels in food: relevance to colorectal cancer screening

Cited by 34 publications

References 10 publications

Screening and Surveillance for the Early Detection of Colorectal Cancer and Adenomatous Polyps, 2008: A Joint Guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology

Screening and Surveillance for the Early Detection of Colorectal Cancer and Adenomatous Polyps, 2008: A Joint Guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology

Faecal immunochemical test-based colorectal cancer screening programme SVIT in Slovenia

Matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry for the detection of hemoglobins as the protein biomarkers for fecal occult blood

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