Pernicious effectors in burns

Allgöwer, M.; Schoenenberger, G. A.; Sparkes, B. G.

doi:10.1016/j.burns.2008.05.012

Cited by 19 publications

(12 citation statements)

References 131 publications

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“…The burned tissue is highly toxic. Indeed, between 100 °C and 500 °C, melting lipids and membrane proteins create toxic lipid-protein complexes responsible for serious systemic problems (73,76). These lipid-protein complexes may in part be responsible in low survival rate of severely burned patients given that administration of anti-lipid-protein complex serum in burned mice greatly increase their survival (76).…”

Section: Burn Pathophysiologymentioning

confidence: 99%

Biotechnological Management of Skin Burn Injuries: Challenges and Perspectives in Wound Healing and Sensory Recovery

Girard

LaverdetBetty

BuhéVirginie

et al. 2017

Tissue Engineering Part B: Reviews

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Many wound management protocols have been developed to improve wound healing after burn with the primordial aim to restore the barrier function of the skin and also provide a better esthetic outcome. Autologous skin grafts remain the gold standard in the treatment of skin burn, but this treatment has its limitation especially for patients presenting limited donor sites due to extensive burn areas. Deep burn injuries also alter the integrity of skin-sensitive innervation and have an impact on patient's quality of life by compromising perceptions of touch, temperature, and pain. Thus, patients can suffer from long-term disabilities ranging from cutaneous sensibility loss to chronic pain. The cellular mechanisms involved in skin reinnervation following injury are not elucidated yet. Depending on the depth of the burn, nerve sprouting can occur from the wound bed or the surrounding healthy tissue, but somehow this process fails to provide correct reinnervation of the wound during scarring. In addition, several clinical observations indicate that damage to the peripheral nervous system influences wound healing, resulting in delayed wound healing or chronic wounds, underlining the role of innervation and neuromediators for normal cutaneous tissue repair development. Promising tissue engineering strategies, including the use of biomaterials, skin substitutes, and stem cells, could provide novel alternative treatments in wound healing and help in improving patient's sensory recovery.

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Section: Burn Pathophysiologymentioning

confidence: 99%

Biotechnological Management of Skin Burn Injuries: Challenges and Perspectives in Wound Healing and Sensory Recovery

Girard

LaverdetBetty

BuhéVirginie

et al. 2017

Tissue Engineering Part B: Reviews

View full text Add to dashboard Cite

show abstract

“…A thermally denatured lipidprotein complex was isolated from the burn extracts that when injected into mice mimicked many effects of burns on the immune system, such as increased susceptibility to Pseudomonas infection, suppressed immune responses to sheep erythrocytes and bacterial endotoxin, and inhibited IL-2-dependent cell growth in culture. 3 Since these early studies of burned-tissue signaling, numerous DAMPs and PAMPs have been found to activate TLRs, and the crystal structures of some of these PAMP-TLR complexes have been solved. 4 DAMPs and PAMPs are among the numerous signaling molecules that activate the innate immune system, protecting damaged tissue from infection, and participating in the repair of burninjured skin.…”

Section: Introductionmentioning

confidence: 99%

Toll-Like Receptor Signaling in Burn Wound Healing and Scarring

D’Arpa

Leung

2017

Advances in Wound Care

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“…The recommendation of early excision, between 1 and 7 days, is mainly based on two assumptions: the burned tissue is prone to infection and, even without being infected, it promotes the production of proinflammatory molecules associated with multiorgan failure. 22,23 But the effectiveness of early excision in reducing mortality or morbidity has not been properly evaluated. One meta-analysis of 6 early excision clinical trials 24 shows that trials have insufficient sample size, poor methodological quality, and it just seems to be a trend to reduce mortality only in patients without inhalation injury.…”

Section: Burnsmentioning

confidence: 99%