Permeability characteristics of the epithelium in the rat caput epididymidis

Hinton, Barry T.; Ss, Howards

doi:10.1530/jrf.0.0630095

Cited by 47 publications

(23 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some active principles such as alkaloids in the aqueous leaf extract of L. hastata could have cross the blood-epididymal barrier and thus alter the microenvironment of the cauda epididymis, leading to the inhibitory effects on metabolic pathways and consequent reduction in sperm viability (Verma and Chinoy, 2001). The impairment of epididymal function due to compromised blood-testes and blood-epididymis barriers as reported in the present study is also supported by previous studies (Hinton and Howards, 1981;Bayala et al, 2011). It is plausible that the effects attributed to L. hastata in this study could have been due to its direct mechanism on the testes.…”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Effect of aqueous leaf extracts of Leptadenia hastata Pers (Decne) on spermiogram and testicular histology in albino rats (Wistar strain)

Maina¹,

Peter²,

Yahi³

et al. 2018

J. Med. Plants Res.

View full text Add to dashboard Cite

This study was designed to determine the effects of prolonged oral administration of aqueous leaf extract of Leptadenia hastata Pers (Decne) on sperm concentration, sperm motility and testicular histology in Wistar rats. Rats were given graded doses (200, 400, 600 and 800 mg kg -1 ) of aqueous leaf extract of L. hastata orally for 28 days. Weekly changes in sperm concentration and motility as well as testicular weight and histology were monitored. Sperm concentration, motility and testicular weights did not show significant change (p>0.05) among the groups, but a significant difference (p<0.05) exist between control group and the group that had the highest dose (800 mg/kg) of L. hastata. Histopathological studies revealed marked depletion of spermatozoa in the testes and epididymis of rats that received 800 mg/kg of L. hastata. Prolonged administration of aqueous leaf extract of L. hastata at 800 mg/kg caused a reduction in total sperm concentration, sperm motility and a reduction in testicular weight in rats.

show abstract

Section: Discussionsupporting

confidence: 91%

“…The blood-epididymal barrier selectively regulates the flow of substances in and out of the epididymal lumen (Hinton and Howards, 1981). Larger molecular weight substances cannot pass easily through this barrier (Uchendu et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Effect of aqueous leaf extracts of Leptadenia hastata Pers (Decne) on spermiogram and testicular histology in albino rats (Wistar strain)

Maina¹,

Peter²,

Yahi³

et al. 2018

J. Med. Plants Res.

View full text Add to dashboard Cite

show abstract

“…It is well known that the blood -epididymis barrier selectively regulates the flow of substances into and out of the epididymal lumen (Hinton and Howards, 1981). Substances of larger molecular weight and many synthetic drugs do not pass freely through this barrier (Minsker et al, 1984;Uchendu, 2000).…”

Section: Discussionmentioning

confidence: 99%

Antispermatogenic effects of aqueous ethanolic extract of Hymenocardia acida stem bark in Wistar rats

Abu¹,

Uchendu²

2010

J. Med. Plants Res.

View full text Add to dashboard Cite

Oral administration of aqueous ethanolic extract of Hymenocardia acida stem bark for eight weeks caused a significant reduction (P < 0.05) in the weights of testes, epididymides, ventral prostrate, seminal vesicles and vasa differentia compared to the control. The treatment related decreases in sperm motility, count, viability and serum testosterone returned to near normal levels on withdrawal of the extract. The groups that received doses of 100, 200 and 400 mg/kg body weight of the extract showed 40, 0 and 0% fertility, respectively. H. acida stem bark extract adversely affected spermatogenesis in Wistar rats.

show abstract

“…Neither is it clear how this may vary according to species or the site in the epididymis being explored. Passage of foreign com¬ ponents from the systemic circulation to the lumen of the rat caput epididymidis appears to be determined to a considerable extent by the molecular weight of the entity in question; larger molecules such as inulin and bovine serum albumin do not reach more than about 5% of the concentration in the blood, whereas tritiated water equilibrates much more freely with the epididymal compartment (Hinton & Howards, 1981). The same appears to be true in principle for the rat cauda epididymidis when studed by luminal perfusion techniques, this region seeming relatively impermeable to larger molecules (Cooper & Waites, 1979).…”

Section: Introductionmentioning

confidence: 99%

Experimental studies on the passage of specific IgG to the lumen of the rabbit epididymis

Weininger¹,

Fisher²,

Rifkin³

et al. 1982

Reproduction

View full text Add to dashboard Cite

Summary. The extent to which specific IgG can reach the lumen of the rabbit cauda epididymidis was investigated by comparison of the concentration in serum and fluid of the cauda epididymidis of a specific IgG raised against dinitrophenylated bovine gamma globulin (DNP\p=n-\BGG).This specific IgG reached the epididymal lumen although in much lower concentration than the levels in serum. The IgG was measured by a specific sensitive radioimmunoassay and in 13 normal males there was a mean molar ratio of 4\m=.\0\m=x\10\m=-\3 (range: 2\m=.\5\p=n-\11\m=.\0\m=x\ 10\ m=-\ 3) between the epididymal lumen and blood; the mean ratio between cerebrospinal fluid and blood was 1\m=.\7\m=x\10\m=-\3 (4 males). Calculations, based on the absolute concentration of anti-DNP IgG in epididymal fluid in relation to total number of spermatozoa and estimated fluid volume in the cauda epididymidis, indicated approximately 40 000 molecules anti-DNP\p=n-\BGG IgG per spermatozoon. This ratio was not affected 6 days after castration or 3\p=n-\4months after vasectomy, but it was about 10 times higher than that of the controls in the cryptic epididymis subjected for 6 days to body temperature.

show abstract

Permeability characteristics of the epithelium in the rat caput epididymidis

Cited by 47 publications

References 16 publications

Effect of aqueous leaf extracts of Leptadenia hastata Pers (Decne) on spermiogram and testicular histology in albino rats (Wistar strain)

Effect of aqueous leaf extracts of Leptadenia hastata Pers (Decne) on spermiogram and testicular histology in albino rats (Wistar strain)

Antispermatogenic effects of aqueous ethanolic extract of Hymenocardia acida stem bark in Wistar rats

Experimental studies on the passage of specific IgG to the lumen of the rabbit epididymis

Contact Info

Product

Resources

About