Antispermatogenic effects of aqueous ethanolic extract of Hymenocardia acida stem bark in Wistar rats

Abu, Adakole Hyacinth; Uchendu, C. N.

doi:10.5897/jmpr10.407

Cited by 18 publications

(17 citation statements)

References 23 publications

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“…This lowered fertility index could be attributed to the summation of the effects of the extract on the parameters analyzed, the contractile effect of the extract and the possible toxicity associated with the extract. Similar observations on reduced fertility indices were made when pregnant rats were treated with Dalbergia axatilis (Uchendu et al, 2000) and Hymenocardia acida (Abu and Uchendu, 2011).…”

Section: Discussionsupporting

confidence: 65%

“…Toxicity of the kidney cells has also been recorded in an attempt to induce abortion on days 15 and 16 using 500 mg/kg body weight of ethanolic fruit extract of Picralima nitida (Mbegbu et al, 2014b). A reduction in FCRL in the treated pregnant rats as observed in the present study had also been reported when Acanthus montanus leaves extract (Nana et al, 2008) and Hymenocardia acida stem bark extract (Abu and Uchendu, 2011) were administered to pregnant rats. The significant difference in the body weights of the rats treated with 500 mg/kg body weight is simply a reflection of the significant reduction in the mean live foetal number (LFN) and foetal crown rump length (FCRL).…”

Section: Discussionsupporting

confidence: 63%

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Effects of Ethanolic Fruit Extract of Picralima nitida (Stapf) on Conception and Estrogenicity in Female Albino Rats

2017

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In search for medicinal plants with renowned reputation of contraceptive and fertility-modulating ability, this work was designed to evaluate the effects of ethanolic fruit extract of Picralima nitida on conception and oestrogenicity using twentyone sexually mature and twenty-four sexually immature female Sprague Dawley rats respectively. For the anti-conceptive study, 0 mg/kg, 50 mg/kg and 500 mg/kg of the extract was administered from day 1to day 4 of gestation (7 rats per group). On the 20th day of gestation, percentage of pregnant females (PPF), live foetal number (LFN), corpora lutea number (CLN), resorbed embryo number (REN), foetal crown-rump length (FCRL) and fertility indices (FI) were evaluated. For the anti-estrogenic study, Groups 1 to 3 (ovariectomized immature female rats) received 0.1 mg/kg of Stilboestrol, 50 mg/kg of the extract, and 0.2 ml of paraffin respectively, once daily for four consecutive days. Group 4 comprised of sham-operated immature female rats with their ovaries intact. The extract elicited absolute conception failure in 42.86% of the treated animals. The extract significantly (p < 0.05) reduced the FCRL, LFN and FI, but increased the REN. Evaluation of the allometric weights of the uterine tissues, endometrial thickness and vaginal opening revealed that the extract at 50 mg/kg body weight was antioestrogenic in activity. Findings from this research strongly suggest that the ethanolic fruit extract of Picralima nitida possesses significant post-coital anti-fertility activity in rats, which could not be attributed to its oestrogenic activity.

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Section: Discussionsupporting

confidence: 65%

Section: Discussionsupporting

confidence: 63%

Effects of Ethanolic Fruit Extract of Picralima nitida (Stapf) on Conception and Estrogenicity in Female Albino Rats

2017

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“…Also, Yamauchi et al (1992); showed almost equal inhibitory effects of grapes from different places of Japan, China, Brazil and USA. Banskota et al (2000) obtained same results for nine different grape samples from Brazil, Peru, the Netherlands and China.…”

Section: Discussionsupporting

confidence: 55%

“…Flavanones (e.g., myricetin, hesperidin, naringin and naringenin) (Peterson and Dwyer, 1998). Flavonoids have been reported to have in vivo and in vitro antioxidant activities through their ability to scavenge the radicals of hydroxyl, peroxyl, superoxide, nitric2 oxide and DPPH (2,2-diphenyl-1-picrylhydrazyl) (Awah and Verla, 2010).…”

Section: Introductionmentioning

confidence: 99%

ANTIOXIDANT AND ANTIMUTAGENIC ACTIVITIES OF TAIF GRAPE (<i>VITIS VINIFERA</i>) CULTIVARS

Fahmi¹,

Nagaty²,

El-Shehawi³

2013

American Journal of Biochemistry and Biotechnology

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Extract of grape Vitis vinifera has been reported to exhibit antioxidant and antimutagenic activities and the phenolic compounds play a vital role in determining these activities. Therefore; the objective of the present study was to evaluate the antioxidant and anti-mutagenic activities as well as the phenolic composition of different grape cultivar extracts collected from Taif region. The grape cultivars namely; Italian, American, Lebanese, Taify b and Taify e were collected at maturity stage to represent Taif region cultivars. The total concentrations of phenoles were determined for the five cultivar extracts and results indicated that the concentrations ranged from 115-960 mg L −1 Gallic Acid Equivalent (GAE). Also, HPLC analysis included was carried out of nine important phenolic compounds namely; Cyanidine chloride, Myricetin, Chrysin, Quercetin, Delphinidine chloride, Malvidine chloride, Naringenin, Galangin and Caffeic acid. Significant differences among cultivars were obtained for each compound. However, the highest cultivar for each compound differed from compound to another. At the same time, DPPH was used to estimate antioxidant activity and the data showed that different grape cultivar extracts were able to quench 47-60% of DPPH radical solution and to exhibited potent radical scavenging activity. Also, antimutagenic activity was measured as a decrease of chromosomal aberrations in bone marrow cells of mice treated with the mutagen Endoxan. Results showed that treatment of mice with grape cultivar extracts resulted in a significant decrease in all types of chromosomal aberrations induced by Endoxan. Also, the anticlastogenic effect was measured using micronulei test and results indicated that all grape cultivar extracts reduced significantly the effect of Endoxan on micronulei test. Finally, treatment of mice with grape cultivar extracts enhanced mitotic index of mice bone marrow cells reduced by Endoxan treatment. The relationship between phenolic compound concentrations and antioxidant capacity was discussed.

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“…Hymenocardia acida on the other hand has an antioxidant activity [12] and pro-oxidant activity [15]. The result of this study show that aluminum chloride did not cause significant (p<0.05) difference in testosterone levels of the rats.…”

Section: Discussionsupporting

confidence: 54%

Spermatogenic and Haematological effects of Aqueous and Ethanolic Extracts of Hymenocardia acida Stem Bark on Aluminium-Induced Toxicity in Male Wistar Rats

Oe¹,

OFC²,

C³

et al. 2017

Insights in Biomed

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This study was designed to determine the spermatogenic and haematological effects of aqueous and ethanolic stem bark extracts of Hymenocardia acida on Aluminium chloride-induced toxicity in male wistar rats. Thirty male albino Wistar rats were used and toxicity was induced using 100 mg/kg body weight (bw) AlCl 3 . The rats were distributed into six groups of five rats each. The drug and extract administration lasted for seven days, thereafter the animals sacrificed. The results indicated that oral dose of 100 mg/kg bw extracts of H. acida did not show any significant (p>0.05) change in testosterone levels when compared with both normal and negative control. Ethanolic extract showed non-significant (p>0.05) increase on Luteinizing hormone (LH) when compared with both normal and negative control group. Administration of AlCl 3 caused a significant (p<0.05) decrease in Follicle Stimulating Hormone (FSH), while the plants extracts caused a non-significant increase when compared with the negative control. Thiobarbituric Acid Reactive Substance (TBARS) increased significantly (p<0.05) in negative control, but decreased significantly in groups treated with aqueous and ethanolic extract of H. acida when compared with the negative control. Induction of AlCl 3 -toxicity caused a non-significant (p>0.05) alterations of most of the haematological parameters evaluated, but administration of the plant extracts was able to mildly ameliorate these effects (especially on RBC and Hb). The result of this study shows AlCl 3 toxicity causes alterations of LH, FSH and TBARS, but aqueous and ethanolic stem bark extracts of H. acida may possibly ameliorate the alteration. Also, AlCl 3 -toxicity mildly influences the synthesis of certain haematological indices, but the extracts may modulate some of this interference.

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Antispermatogenic effects of aqueous ethanolic extract of Hymenocardia acida stem bark in Wistar rats

Cited by 18 publications

References 23 publications

Effects of Ethanolic Fruit Extract of Picralima nitida (Stapf) on Conception and Estrogenicity in Female Albino Rats

Effects of Ethanolic Fruit Extract of Picralima nitida (Stapf) on Conception and Estrogenicity in Female Albino Rats

ANTIOXIDANT AND ANTIMUTAGENIC ACTIVITIES OF TAIF GRAPE (<i>VITIS VINIFERA</i>) CULTIVARS

Spermatogenic and Haematological effects of Aqueous and Ethanolic Extracts of Hymenocardia acida Stem Bark on Aluminium-Induced Toxicity in Male Wistar Rats

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