Permeability characteristics of calcium alginate films

Julian, Thomas N.; Radebaugh, Galen W.; Wisniewski, Stephen J.

doi:10.1016/0168-3659(88)90008-9

Cited by 38 publications

(9 citation statements)

References 8 publications

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“…Furthermore. Julian et al (1988) have investigated the effects of calcium ion diffusion on the permeability of calcium alginate films. Similar work has also been done by Aspinall (1982).…”

mentioning

confidence: 99%

Mathematical modelling of protein diffusion in microcapsules: A comparison with experimental results

Kwok¹,

Kiparissides²,

Yuet³

et al. 1991

Can J Chem Eng

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The objective of this study was to develop a general diffusion model for describing mass transport phenomena and membrane diffusivities in alginate—polylysine (PLL) microcapsules. Good agreement between calculated and experimental protein concentration profiles was obtained based on a microcapsule model, consisting of a capsule membrane containing a partially impermeable alginate gel core with a decreasing gel pore size towards the centre of the capsule. The apparent size of the impermeable gel core and the capsule membrane permeability were directly dependent on the size of the diffusing protein and the alginate‐PLL reaction time. The presence of this impermeable core may hinder the commercial and clinical use of these microcapsules in cell culture engineering and cell transplantation by affecting cell viability.

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“…Furthermore. Julian et al (1988) have investigated the effects of calcium ion diffusion on the permeability of calcium alginate films. Similar work has also been done by Aspinall (1982).…”

mentioning

confidence: 99%

Mathematical modelling of protein diffusion in microcapsules: A comparison with experimental results

Kwok¹,

Kiparissides²,

Yuet³

et al. 1991

Can J Chem Eng

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“…Calcium ion crosslinks the polymer chains by its bond to polycarboxylic acid group present in sodium alginate. Conformational changes of polymer chain due to the cross-linking slow the diffusion of calcium ion into the interior of the matrix and thus leading to stoppage of cross-linking process (Julian, Radebaugh, & Wisniewski, 1988). This also supports the finding that longer cross-linking time is unnecessary and that it may further reduce drug entrapment by promoting diffusion of the drug through matrix into calcium chloride solution bath.…”

Section: Cross-linking Treatment Of Pelletsmentioning

confidence: 62%

Masking of Unpleasant Gustatory Sensation by Cross-Linking of Dehydrated Paracetamol Alginate Pellets Produced by Extrusion-Spheronization

Kulkarni

Amin

2008

Drug Development and Industrial Pharmacy

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Alginate paracetamol pellets were prepared by extrusion-spheronization process. The process variables studied were wet mass mixing time, feed rate, die opening diameter, spheronization residence time, feed rate, disk speed, and drying. The formulation variables studied were granulation fluid composition and level and drug-to-excipient ratios. The dried pellets were cross-linked with calcium chloride solution. The cross-linked pellets were evaluated for dissolution test, friability test, sphericity, flow behavior, particle size distribution, aggregation, water uptake, drug entrapment, and yield. Gustatory sensation test exhibited successful taste-masking of paracetamol by present approach.

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“…Factors such as solution temperature, calcium concentration, stirring pace and time used throughout cross-linking along with physical parameters of the dried granules were studied [71]. It was seen that rapid crosslinking takes place at elevated concentrations of CaCl2 compared to low concentrations [72][73][74]. Treatment conditions controlled the yield, early release, drug entrapment and extent of cross-linking [45,75].…”

Section: Hydrogelsmentioning

confidence: 99%

Chemical Modifications of Alginate and Its Derivatives

Nataraj¹,

Reddy²

2020

Int J Chem Res

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Alginate is a polysaccharide obtained from seaweeds that are abundantly available and have shown great potential for diverse industrial applications. However, alginate lacks properties such as stability under aqueous conditions and it is difficult to control the rate of degradation of alginate-based materials, crucial for various medical applications. Therefore, researchers have modified alginate using physical or chemical approaches to enhance physical properties, biocompatibility, solubility and also to control the biodegradability of alginate-based materials. Crosslinking using ionic, covalent, photo and enzymatic approaches are one of the preferred methods for modifying the properties of alginates and its derivatives. Crosslinking binds the individual polymer chains with one another to form a network that enhances mechanical properties and stability. Among the different crosslinking approaches, ionic crosslinking provides biomaterials with limited stability whereas biomaterials with high mechanical stability can be prepared by covalent crosslinking. Although a wide variety of crosslinking chemicals and approaches are available to make alginate suitable for various applications, the methods used, properties and applications of the cross-linked materials vary significantly between studies. There are very few reports that have compared and evaluated the benefits of using different crosslinking approaches and the properties and applications of cross-linked alginate. In this review, the various methods of crosslinking alginates, their advantages, and limitations have been reviewed with particular emphasis on medical applications of alginate. The data for writing the review was obtained using search engines like Google scholar, Sci-hub and Sci finder and the keywords used include alginate, crosslinking, ionic, covalent, photo, enzymatic, biomedical applications.

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Permeability characteristics of calcium alginate films

Cited by 38 publications

References 8 publications

Mathematical modelling of protein diffusion in microcapsules: A comparison with experimental results

Mathematical modelling of protein diffusion in microcapsules: A comparison with experimental results

Masking of Unpleasant Gustatory Sensation by Cross-Linking of Dehydrated Paracetamol Alginate Pellets Produced by Extrusion-Spheronization

Chemical Modifications of Alginate and Its Derivatives

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