Permanent, non-leaching antibacterial surfaces—2: How high density cationic surfaces kill bacterial cells

Murata, Hironobu; Koepsel, Richard R.; Matyjaszewski, Krzysztof; Russell, Alan J.

doi:10.1016/j.biomaterials.2007.06.012

Cited by 649 publications

(714 citation statements)

References 44 publications

(77 reference statements)

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“…Several antimicrobial surfaces have been described in the literature, including non-antibiotic antimicrobial agents such as silver, salicylic acid, quaternary ammonium compounds, phenol derivatives, chlorhexidine and nitric oxide [3,5,13,33]. However, many of these compounds are associated with anaphylaxis, cytotoxicity or low efficiency [5,13].…”

Section: Antimicrobial Coatingsmentioning

confidence: 99%

Covalent immobilization of antimicrobial peptides (AMPs) onto biomaterial surfaces

et al. 2011

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a b s t r a c tBacterial adhesion to biomaterials remains a major problem in the medical devices field. Antimicrobial peptides (AMPs) are well-known components of the innate immune system that can be applied to overcome biofilm-associated infections. Their relevance has been increasing as a practical alternative to conventional antibiotics, which are declining in effectiveness. The recent interest focused on these peptides can be explained by a group of special features, including a wide spectrum of activity, high efficacy at very low concentrations, target specificity, anti-endotoxin activity, synergistic action with classical antibiotics, and low propensity for developing resistance. Therefore, the development of an antimicrobial coating with such properties would be worthwhile. The immobilization of AMPs onto a biomaterial surface has further advantages as it also helps to circumvent AMPs' potential limitations, such as short half-life and cytotoxicity associated with higher concentrations of soluble peptides. The studies discussed in the current review report on the impact of covalent immobilization of AMPs onto surfaces through different chemical coupling strategies, length of spacers, and peptide orientation and concentration. The overall results suggest that immobilized AMPs may be effective in the prevention of biofilm formation by reduction of microorganism survival post-contact with the coated biomaterial. Minimal cytotoxicity and longterm stability profiles were obtained by optimizing immobilization parameters, indicating a promising potential for the use of immobilized AMPs in clinical applications. On the other hand, the effects of tethering on mechanisms of action of AMPs have not yet been fully elucidated. Therefore, further studies are recommended to explore the real potential of immobilized AMPs in health applications as antimicrobial coatings of medical devices.

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Section: Antimicrobial Coatingsmentioning

confidence: 99%

Covalent immobilization of antimicrobial peptides (AMPs) onto biomaterial surfaces

et al. 2011

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“…The surface density of quaternary ammonium ions was measured using a fluorescein staining test [21]. Samples (10 mm 2 ) coated with Quat-12-PU using either solution or nanoparticulate formulations were dipped into 10 ml of a 1 % fluorescein Na solution in distilled water for 10 min at 37°C with gentle shaking.…”

Section: Quantitation Of Surface Quaternary Aminesmentioning

confidence: 99%

“…Antibacterial activity for polyQACs depends on the surface charge density of quaternary ammonium ions [21]. We hypothesized that the charge density could be increased by applying additional layers of Quat-12-PU onto surfaces.…”

Section: Determination Of Coating Cycle By Charge Density Of Quaternamentioning

confidence: 99%

Antiviral and Antibacterial Polyurethanes of Various Modalities

Park

Larson

Klibanov

et al. 2013

Appl Biochem Biotechnol

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We have prepared and characterized a new polyurethane-based antimicrobial material, N,N-dodecyl,methyl-polyurethane (Quat-12-PU). It exhibits strong antiviral and antibacterial activities when coated (as an organic solution or an aqueous nanosuspension) onto surfaces and antibacterial activity when electrospun into nanofibers. Quat-12-PU surfaces are able to kill airborne Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli bacteria, as well as inactivate the enveloped influenza virus (but not the non-enveloped poliovirus).

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“…Examples of active antibacterial coatings include cationic polymers such as chitosan (Huh et al, 2001;Fu et al, 2005) and polymers containing quaternary ammonium (Lee et al, 2004;Cheng et al, 2005;Murata et al, 2007) and pyridinium (Tiller et al, 2001;Tiller et al, 2002;Cen et al, 2004;Krishnan et al, 2006) functional groups. The antibacterial effect of silver can be exploited by incorporation of silver salts or silver nanoparticles into coatings (Sambhy et al, 2006;Marini et al, 2007;Ramstedt et al, 2007a;Ramstedt et al, 2007b).…”

Section: Introductionmentioning

confidence: 99%

Surface-immobilised antimicrobial peptoids

et al. 2008

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Surface modification techniques that create surfaces capable of killing adherent bacteria are promising solutions to infections associated with implantable medical devices. Antimicrobial peptoid oligomers (ampetoids) that were designed to mimic helical antimicrobial peptides were synthesized with a peptoid spacer chain to allow mobility and an adhesive peptide moiety for easy and robust immobilization onto substrates. TiO 2 substrates were modified with the ampetoids and subsequently backfilled with an antifouling polypeptoid polymer in order to create polymer surface coatings composed of both antimicrobial (active) and antifouling (passive) peptoid functionalities. Confocal microscopy images show that the membranes of adherent E. coli were damaged after 2 h exposure to the modified substrates, suggesting that ampetoids retain antimicrobial properties even when immobilized onto substrates.

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Permanent, non-leaching antibacterial surfaces—2: How high density cationic surfaces kill bacterial cells

Cited by 649 publications

References 44 publications

Covalent immobilization of antimicrobial peptides (AMPs) onto biomaterial surfaces

Covalent immobilization of antimicrobial peptides (AMPs) onto biomaterial surfaces

Antiviral and Antibacterial Polyurethanes of Various Modalities

Surface-immobilised antimicrobial peptoids

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