2016
DOI: 10.18632/aging.100928
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Abstract: The epidermis is continuously renewed by stem cell proliferation and differentiation. Basal keratinocytes append the dermal‐epidermal junction, a cell surface‐associated, extracellular matrix that provides structural support and influences their behaviour. It consists of laminins, type IV collagen, nidogens, and perlecan, which are necessary for tissue organization and structural integrity. Perlecan is a heparan sulfate proteoglycan known to be involved in keratinocyte survival and differentiation. Aging affec… Show more

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Cited by 22 publications
(24 citation statements)
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References 71 publications
(90 reference statements)
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“…Basal epidermal cells divide asymmetrically, generating a committed suprabasal cell and a proliferative basal cell, and during this process β1 integrin, but not β4 integrin, contributing to the spindle orientation . Perlecan regulates both the survival and the self‐renewal capacity of basal keratinocytes by controlling the bioavailability of perlecan‐binding soluble factors involved in epidermal morphogenesis . Our study revealed that HEI increased the basal localizations of β1 integrin, perlecan and heparan sulfate.…”
Section: Discussionmentioning
confidence: 66%
“…Basal epidermal cells divide asymmetrically, generating a committed suprabasal cell and a proliferative basal cell, and during this process β1 integrin, but not β4 integrin, contributing to the spindle orientation . Perlecan regulates both the survival and the self‐renewal capacity of basal keratinocytes by controlling the bioavailability of perlecan‐binding soluble factors involved in epidermal morphogenesis . Our study revealed that HEI increased the basal localizations of β1 integrin, perlecan and heparan sulfate.…”
Section: Discussionmentioning
confidence: 66%
“…Moreover, perlecan is involved in regulating solute transport and mechanosensing in the osteocyte lacunar-canalicular system [62], and its protein core can withstand over 100 pN of tension, suggesting that perlecan could act as an elastic tether in the lacunar-canalicular system [63]. Collectively, these properties culminate in a multifaceted biological agent that has been implicated in diseases such as osteoarthritis [64], atherosclerosis [65,66], muscle hypertrophy [67] cancer progression [22,24,27,68,69], aging [70], and pulmonary hypertension [71]…”
Section: Form Follows Function: Overview Of the Perlecan Gene And Promentioning
confidence: 99%
“…Perlecan gets a stabilizing function for basement membrane,4 by its interaction with type IV collagen and nidogen 1 and 2, but seems to be important also for wound healing at the functional level by the control of signaling molecules5,6 and stem cell niche 7…”
Section: Introductionmentioning
confidence: 99%