volume 8, issue 4, P751-768 2016
DOI: 10.18632/aging.100928
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Morgan Dos Santos, Anna Michopoulou, Valérie André‐Frei, Sophie Boulesteix, Christine Guicher, Guila Dayan, John Whitelock, Odile Damour, Patricia Rousselle

Abstract: The epidermis is continuously renewed by stem cell proliferation and differentiation. Basal keratinocytes append the dermal‐epidermal junction, a cell surface‐associated, extracellular matrix that provides structural support and influences their behaviour. It consists of laminins, type IV collagen, nidogens, and perlecan, which are necessary for tissue organization and structural integrity. Perlecan is a heparan sulfate proteoglycan known to be involved in keratinocyte survival and differentiation. Aging affec…

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