2017
DOI: 10.1016/j.matbio.2016.09.003
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Abstract: Perlecan, a large basement membrane heparan sulfate proteoglycan, is expressed in a wide array of tissues where it regulates diverse cellular processes including bone formation, inflammation, cardiac development, and angiogenesis. Here we provide a contemporary review germane to the biology of perlecan encompassing its genetic regulation as well as an analysis of its modular protein structure as it pertains to function. As perlecan signaling from the extracellular matrix converges on master regulators of autop… Show more

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Cited by 155 publications
(129 citation statements)
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References 158 publications
(192 reference statements)
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“…BMs are highly specialized extracellular matrices assembled primarily from laminins, collagens, heparin sulfate proteoglycans, and nidogens, although the precise composition is tissue-specific [27-29]. They are frequently recognized at the transmission electron microscope (TEM) level as two adjacent layers termed the lamina lucida and lamina densa (Fig.…”
Section: Basement Membrane Structure and Assemblymentioning
confidence: 99%
See 1 more Smart Citation
“…BMs are highly specialized extracellular matrices assembled primarily from laminins, collagens, heparin sulfate proteoglycans, and nidogens, although the precise composition is tissue-specific [27-29]. They are frequently recognized at the transmission electron microscope (TEM) level as two adjacent layers termed the lamina lucida and lamina densa (Fig.…”
Section: Basement Membrane Structure and Assemblymentioning
confidence: 99%
“…Once initiated, the laminin scaffold enables recruitment and assembly of remaining BM components, including nidogen-1, nidogen-2, perlecan, and collagen type IV, to regenerate the structurally and functionally mature BM [27-29]. …”
Section: Basement Membrane Structure and Assemblymentioning
confidence: 99%
“…Перлекан (ГСПГ 2) (perlecan/HSPG2) является ос-новным компонентом базальных мембран, наряду с ламинином, коллагеном 4 и нидогеном/энтактином [36]. Он экспрессируется в широком спектре тканей, где регулирует разнообразные клеточные процессы, включая формирование костей, воспаление и ангио-генез, в первую очередь благодаря его способности взаимодействовать с различными лигандами и рецеп-торами тирозинкиназ.…”
Section: протеогликаны базальной мембраныunclassified
“…Their properties strongly depend on their composition in terms of, both, collagens and non-collagenous molecules (e.g. COMP, matrilins, decorin, fibromodulin, lumican, perlecan, and collagen VI-containing microfibrils) [8][9][10][11][12][13]. In cartilage fibrils, for example, the inclusion of collagen XI as a fibrillar nucleus is vital for the incorporation of the main component, collagen II [14,15].…”
Section: Introductionmentioning
confidence: 99%