Perivascular space fluid contributes to diffusion tensor imaging changes in white matter

Sepehrband, Farshid; Cabeen, Ryan P.; Choupan, Jeiran; Barisano, Giuseppe; Law, Meng; Toga, Arthur W.

doi:10.1101/395012

Cited by 3 publications

(2 citation statements)

References 85 publications

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“…In addition to its potential clinical relevance, mapping PVS can be useful to improve the accuracy of other quantitative MRI techniques as well, because these could be affected by the partial presence of PVS in image voxels. Recently, we have shown that ignoring PVS could systematically affect how diffusion tensor imaging measures can be interpreted (Sepehrband et al, 2019). Such contribution and its potential confounding effect may be ameliorated if PVS is mapped and included in the analysis.…”

Section: Discussionmentioning

confidence: 99%

Image processing approaches to enhance perivascular space visibility and quantification using MRI

Sepehrband

Barisano

Sheikh‐Bahaei

et al. 2019

Preprint

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Word count: 4080 Number of figures: 8 Number of tables: 1 AbstractImaging the perivascular spaces (PVS), also known as Virchow-Robin space, has significant clinical value, but there remains a need for neuroimaging techniques to improve mapping and quantification of the PVS. Current technique for PVS evaluation is a scoring system based on visual reading of visible PVS in regions of interest, and often limited to large caliber PVS.Enhancing the visibility of the PVS could support medical diagnosis and enable novel neuroscientific investigations. Increasing the MRI resolution is one approach to enhance the visibility of PVS but is limited by acquisition time and physical constraints. Alternatively, image processing approaches can be utilized to improve the contrast ratio between PVS and surrounding tissue. Here we combine T1-and T2-weighted images to enhance PVS contrast, intensifying the visibility of PVS. The Enhanced PVS Contrast (EPC) was achieved by combining T1-and T2-weighted images that were adaptively filtered to remove non-structured highfrequency spatial noise. EPC was evaluated on healthy young adults by presenting them to two expert readers and also through automated quantification. We found that EPC improves the conspicuity of the PVS and aid resolving a larger number of PVS. We also present a highly reliable automated PVS quantification approach, which was optimized using expert readings.

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Section: Discussionmentioning

confidence: 99%

Image processing approaches to enhance perivascular space visibility and quantification using MRI

Sepehrband

Barisano

Sheikh‐Bahaei

et al. 2019

Preprint

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“…We are aware of only one study where the effects of PVS on quantitative MRI were investigated. Sepehrband et al showed that diffusion tensor imaging measures, such as fractional anisotropy and mean diffusivity, are biased by PVS 20 . These authors demonstrate that this effect is due to the high diffusivity of the fluid within the PVS, and to the restricted diffusion of PVS fluid in the direction perpendicular to the vessel axis.…”

Section: Discussionmentioning

confidence: 99%

The role of diffusion and perivascular spaces in dynamic susceptibility contrast MRI

Doucette

Kames

Hernández‐Torres

et al. 2019

Preprint

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We investigated the effects of brain tissue orientation, diffusion, and perivascular spaces on dynamic susceptibility contrast MRI. A 3D numerical model of a white matter voxel was created that consists of an isotropic capillary bed and anisotropic vessels that run in parallel with white matter tracts and are surrounded by perivascular spaces. The signal within the voxel was simulated by solving the Bloch-Torrey equation.

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Nonparenchymal fluid is the source of increased mean diffusivity in preclinical Alzheimer's disease

Sepehrband

Cabeen

Barisano

et al. 2019

Alz & Dem Diag Ass & Dis Mo

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Introduction Although increased mean diffusivity of the white matter has been repeatedly linked to Alzheimer’s disease pathology, the underlying mechanism is not known. Methods Here, we used ADNI-3 multishell diffusion magnetic resonance imaging data to separate the diffusion signal of the parenchyma from less hindered fluid pools within the white matter such as perivascular space fluid and fluid-filled cavities. Results We found that the source of the pathological increase of the mean diffusivity is the increased nonparenchymal fluid, often found in lacunes and perivascular spaces. In this cohort, the cognitive decline was significantly associated with the fluid increase and not with the microstructural changes of the white matter parenchyma itself. The white matter fluid increase was dominantly observed in the sagittal stratum and anterior thalamic radiation. Discussion These findings are positive steps toward understanding the pathophysiology of white matter alteration and its role in the cognitive decline.

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Perivascular space fluid contributes to diffusion tensor imaging changes in white matter

Cited by 3 publications

References 85 publications

Image processing approaches to enhance perivascular space visibility and quantification using MRI

Image processing approaches to enhance perivascular space visibility and quantification using MRI

The role of diffusion and perivascular spaces in dynamic susceptibility contrast MRI

Nonparenchymal fluid is the source of increased mean diffusivity in preclinical Alzheimer's disease

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