The role of diffusion and perivascular spaces in dynamic susceptibility contrast MRI

Abstract

We investigated the effects of brain tissue orientation, diffusion, and perivascular spaces on dynamic susceptibility contrast MRI. A 3D numerical model of a white matter voxel was created that consists of an isotropic capillary bed and anisotropic vessels that run in parallel with white matter tracts and are surrounded by perivascular spaces. The signal within the voxel was simulated by solving the Bloch-Torrey equation.

The glial framework reveals white matter fiber architecture in human and primate brains

“…S8 and S9). Although the blood volume in white matter is estimated to be only 2.57% ( 32 ), the estimated peak orientation could be affected in atypical regions with very high blood vessel volume (fig. S7).…”