Perivascular biodegradable microneedle cuff for reduction of neointima formation after vascular injury

Lee, KangJu; Park, Seung Hyun; Lee, Ji Yong; Joo, Hyun‐Chel; Jang, Eui Hwa; Youn, Young Nam; Ryu, WonHyoung

doi:10.1016/j.jconrel.2014.07.007

Cited by 45 publications

(27 citation statements)

References 28 publications

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“…One of the methods to provide MNs electric function is to coat the MN with electrochemical components. As a result of the development in micro fabrication technology, MN configurations of biocompatible materials are typically achieved using relatively simple methodologies such as mold casting [ 34 – 37 ] and drawing lithography [ 38 , 39 ]. However, these methods are not suitable for conductive materials including metals compared to removal machining including MEMS processes.…”

Section: Mns As Sensing Probesmentioning

confidence: 99%

Functionalized microneedles for continuous glucose monitoring

Takeuchi

Kim

2018

Nano Convergence

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Microneedles (MNs) have been established as promising medical devices as they are minimally invasive, cause less pain, and can be utilized for self-administration of drugs by patients. There has been rapid development in MNs for transdermal monitoring and diagnostic systems, following the active research on fabrication methods and applications for drug delivery. In this paper, recent investigations on bio-sensing using MNs are reviewed in terms of the applicability to continuous glucose monitoring system (CGMS), which is one of the main research focuses of medical engineering technologies. The trend of the functionalized MNs can be categorized as follows: (i) as a sensing probe, and (ii) as a biological fluid collector. MNs as in vivo sensors are mainly integrated or coated with conductive materials to have the function as electrodes. MNs as fluid collectors are given a certain geometrical design, such as a hollow and porous structure aided by a capillary action or negative pressure, to extract the interstitial fluids or blood for ex vivo analysis. For realization of CGMS with MNs, a long-term accurate measurement by the MN-based sensing probe or a fluidic connection between the MN-based fluid collector and the existing microfluidic measurement systems should be investigated.

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Section: Mns As Sensing Probesmentioning

confidence: 99%

Functionalized microneedles for continuous glucose monitoring

Takeuchi

Kim

2018

Nano Convergence

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“…Microneedles have also been used for treatment of allergy (Shakya and Gill, 2015), local delivery of anesthetics (Zhang et al, 2012a), for treatment of anemia (Peters et al, 2012), treatment of type 2 diabetes (Liu et al, 2016), treatment of intimal hyperplasia (Lee et al, 2017b), corneal neovascularization (Kim et al, 2014), treatment of enuresis (Cormier et al, 2004), and treatment of cancer (Ma et al, 2015;Jain et al, 2016). Coated microneedles have also been used in immunotherapy of type 1 diabetes (Zhao et al, 2017) and for treatment of osteoporosis (Katsumi et al, 2017) and restenosis (Lee et al, 2014).…”

Section: Biomedical Applications Animal Models and Human Studies Pumentioning

confidence: 99%

“…microneedle are not impacted when a different drug is coated on it surface. Furthermore, the coated microneedle system has been evaluated as a delivery system for not just the skin (Prausnitz, 2017) but also the eye (Jiang et al, 2007;Kim et al, 2014;Song et al, 2015), vascular tissue (Lee et al, 2014(Lee et al, , 2017b, and the oral cavity (McNeilly et al, 2014;Ma et al, 2015). A recent article by Rzhevskiy et al (2018) has reviewed the use of microneedles for drug delivery into different tissues and organs.…”

Section: Introductionmentioning

confidence: 99%

Microneedle Coating Methods: A Review with a Perspective

Ingrole¹,

Gill²

2019

J Pharmacol Exp Ther

111

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A coated microneedle array comprises sharp micrometer-sized needle shafts attached to a base substrate and coated with a drug on their surfaces. Coated microneedles are under investigation for drug delivery into the skin and other tissues, and a broad assortment of active materials, including small molecules, peptides, proteins, deoxyribonucleic acids, and viruses, have been coated onto microneedles. To coat the microneedles, different methods have been developed. Some coating methods achieve selective coating of just the microneedle shafts, whereas other methods coat not only microneedle shafts but also the array base substrate. Selective coating of just the microneedle shafts is more desirable since it provides control over drug dosage, prevents drug waste, and offers high delivery efficiency. Different excipients are added to the coating liquid to modulate its viscosity and surface tension in order to achieve uniform coatings on microneedles. Coated microneedles have been used in a broad range of biomedical applications. To highlight these different applications, a table summarizing the different active materials and the amounts coated on microneedles is provided. We also discuss factors that should be considered when deciding suitability of coated microneedles for new-drug delivery applications. In recent years, many coated microneedles have been investigated in human clinical trials, and there is now a strong effort to bring the first coated microneedle-based product to market.

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“…Figure 3: Images of different perivascular administration systems, adapted from the literature: A: Braided nitinol mesh [71]; B: Knitted nitinol mesh [72]; C: Provena ® PET mesh, courtesy of Dr. Fr. Saucy; D: Dipyridamole microspheres in PLGA-PEG-PLGA Regel ® gel [73]; E: Sirolimus in PLGA-PEG-PLGA Regel ® gel [67]; F: Sirolimus on PET mesh [74]; G: Sirolimus in PCL wrap [75]; H: Mithramycin in EVAc (polyethylene vinyl acetate) + PEG cuff [76]; I: Paclitaxel-loaded PLGA microneedle cuff [77]; J: Sunitinib-loaded PLGA wrap [78]. Copyright owners granted their permission for re-use.…”

Section: Properties Of Perivascular Systemsmentioning

confidence: 99%

Perivascular medical devices and drug delivery systems: Making the right choices

et al. 2017

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Perivascular medical devices and perivascular drug delivery systems are conceived for local application around a blood vessel during open vascular surgery. These systems provide mechanical support and/or pharmacological activity for the prevention of intimal hyperplasia following vessel injury. Despite abundant reports in the literature and numerous clinical trials, no efficient perivascular treatment is available. In this review, the existing perivascular medical devices and perivascular drug delivery systems, such as polymeric gels, meshes, sheaths, wraps, matrices, and metal meshes, are jointly evaluated. The key criteria for the design of an ideal perivascular system are identified. Perivascular treatments should have mechanical specifications that ensure system localization, prolonged retention and adequate vascular constriction. From the data gathered, it appears that a drug is necessary to increase the efficacy of these systems. As such, the release kinetics of pharmacological agents should match the development of the pathology. A successful perivascular system must combine these optimized pharmacological and mechanical properties to be efficient.

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Perivascular biodegradable microneedle cuff for reduction of neointima formation after vascular injury

Cited by 45 publications

References 28 publications

Functionalized microneedles for continuous glucose monitoring

Functionalized microneedles for continuous glucose monitoring

Microneedle Coating Methods: A Review with a Perspective

Perivascular medical devices and drug delivery systems: Making the right choices

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