Peritubular Dentin Formation: Crystal Organization and the Macromolecular Constituents in Human Teeth

Weiner, Steve; Veis, Arthur; Beniash, Elia; Arad, Talmon; Dillon, Jerry W.; Sabsay, Boris; Siddiqui, Farida

doi:10.1006/jsbi.1999.4096

Cited by 123 publications

(131 citation statements)

References 35 publications

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“…Mineralized biological materials, such as shells, bone, and teeth, have been attracting a great deal of attention during the last several decades [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15], specifically, in more recent years [1][2][3][4][5][6], due to their unique microstructures and superior mechanical properties. The limnetic shell is a typical example of such biomaterial; it consists of nacreous and prismatic structures which display unique hierarchical features.…”

Section: Introductionmentioning

confidence: 99%

Hierarchical structure observation and nanoindentation size effect characterization for a limnetic shell

Song

Fan

et al. 2015

Acta Mech Sin

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In the present research, hierarchical structure observation and mechanical property characterization for a type of biomaterial are carried out. The investigated biomaterial is Hyriopsis cumingii, a typical limnetic shell, which consists of two different structural layers, a prismatic "pillar" structure and a nacreous "brick and mortar" structure. The prismatic layer looks like a "pillar forest" with variationsection pillars sized on the order of several tens of microns. The nacreous material looks like a "brick wall" with bricks sized on the order of several microns. Both pillars and bricks are composed of nanoparticles. The mechanical properties of the hierarchical biomaterial are measured by using the nanoindentation test. Hardness and modulus are measured for both the nacre layer and the prismatic layer, respectively. The nanoindentation size effects for the hierarchical structural materials are investigated experimentally. The results show that the prismatic nanostructured material has a higher stiffness and hardness than the nacre nanostructured material. In addition, the nanoindentation size effects for the hierarchical structural materials are described theoretically, by using the trans-scale mechanics theory considering both strain gradient effect and the surface/interface effect. The modeling results are consistent with experimental ones.

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Section: Introductionmentioning

confidence: 99%

Hierarchical structure observation and nanoindentation size effect characterization for a limnetic shell

Song

Fan

et al. 2015

Acta Mech Sin

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“…Gotliv and co-workers (2006) also pointed out that bovine peritubular dentin differs form intertubular dentin not only on the degree of mineralization, but also in the amount and nature of mineral elements and aminoacids. Human peritubular dentin has been reported to contain phosphoproteins and acidic 218 G. Orsini et al glycosylated proteins (Weiner et al 1999, Chaussain-Miller et al 2007.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical localization of dentin matrix protein 1 in human dentin

Orsini¹,

Ruggeri²,

Mazzoni³

et al. 2009

Eur J Histochem

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Dentin matrix protein 1 (DMP1) is a non-collagenous matrix protein with a recognized role in the formation of mineralized tissues such as dentin. The aim of this study was to analyze the distribution of DMP1 in human dentin by means of immunofluorescence and high-resolution immunogold labeling. Fully developed, sound human dentin specimens were submitted to fluorescence labeling and post-embedding immunolabeling techniques with a rabbit polyclonal antihuman DMP1 antibody followed by corresponding fluorochrome-conjugated or gold-conjugated secondary antibodies. Both immunofluorescence and immunogold labeling showed an intense labeling associated with the peritubular dentin. In addition, at the ultrastructural level, there was also a moderate and diffuse immunoreaction over intertubular dentin, and a weak labeling within predentin which increased in density towards the mineralization front. This study suggests that in adult human teeth, like in rodents, DMP1 is prevalently concentrated at the level of peritubular dentin and this feature is preserved also in fully developed-teeth. These data are consistent with what has been observed in rodents and suggest that DMP1 plays a role in maintenance of the dentin tubular space.

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“…Thus, the composition of intertubular dentin is primarily mineralized collagen fibrils; the fibrils are described as a composite of a collagen framework and thin plate-shaped carbonate apatite crystals whose c-axes are aligned with the collagen fibril axis [60]. In healthy dentin, the majority of the mineralized collagen fibrils are perpendicular to the tubules [56].…”

Section: Dentinmentioning

confidence: 99%

Multiscale mechanics of hierarchical structure/property relationships in calcified tissues and tissue/material interfaces

Katz

Misra

Spencer

et al. 2007

Materials Science and Engineering: C

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This paper presents a review plus new data that describes the role hierarchical nanostructural properties play in developing an understanding of the effect of scale on the material properties (chemical, elastic and electrical) of calcified tissues as well as the interfaces that form between such tissues and biomaterials. Both nanostructural and microstructural properties will be considered starting with the size and shape of the apatitic mineralites in both young and mature bovine bone. Microstructural properties for human dentin and cortical and trabecular bone will be considered. These separate sets of data will be combined mathematically to advance the effects of scale on the modeling of these tissues and the tissue/biomaterial interfaces as hierarchical material/structural composites. Interfacial structure and properties to be considered in greatest detail will be that of the dentin/adhesive (d/a) interface, which presents a clear example of examining all three material properties, (chemical, elastic and electrical). In this case, finite element modeling (FEA) was based on the actual measured values of the structure and elastic properties of the materials comprising the d/a interface; this combination provides insight into factors and mechanisms that contribute to premature failure of dental composite fillings. At present, there are more elastic property data obtained by microstructural measurements, especially high frequency ultrasonic wave propagation (UWP) and scanning acoustic microscopy (SAM) techniques. However, atomic force microscopy (AFM) and nanoindentation (NI) of cortical and trabecular bone and the dentin-enamel junction (DEJ) among others have become available allowing correlation of the nanostructural level measurements with those made on the microstructural level.

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Peritubular Dentin Formation: Crystal Organization and the Macromolecular Constituents in Human Teeth

Cited by 123 publications

References 35 publications

Hierarchical structure observation and nanoindentation size effect characterization for a limnetic shell

Hierarchical structure observation and nanoindentation size effect characterization for a limnetic shell

Immunohistochemical localization of dentin matrix protein 1 in human dentin

Multiscale mechanics of hierarchical structure/property relationships in calcified tissues and tissue/material interfaces

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