Peritonitis Due to Rothia dentocariosa in a Patient Receiving Continuous Ambulatory Peritoneal Dialysis

Bibashi, Evangelia; Kokolina, Elisabeth; Mitsopoulos, Efstathios; Κοντοπούλου, Κωνσταντίνα; Sofianou, Danai

doi:10.1086/517226

Cited by 38 publications

(33 citation statements)

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“…G. bethesdensis has since been cultured from at least 5 patients with CGD in the United States (15,16) and 1 in Spain (23), justifying its classification as an emerging pathogen in this primary immunodeficiency. Although the bacterial family to which G. bethesdensis belongs-the Acetobacteraceae-was previously considered nonpathogenic in humans, case reports of human infections by other members of this family are being published with increasing frequency (1,2,5,6,9,12,17,22,26,27). Common elements of infection by these other Acetobacteraceae species appear to include intravenous drug administration (for either medicinal or recreational purposes), organ transplant, or chronic medical problems requiring dialysis.…”

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confidence: 99%

Innate Immunity against Granulibacter bethesdensis, an Emerging Gram-Negative Bacterial Pathogen

et al. 2012

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Acetic acid bacteria were previously considered nonpathogenic in humans. However, over the past decade, five genera of Acetobacteraceae have been isolated from patients with inborn or iatrogenic immunodeficiencies. Here, we describe the first studies of the interactions of the human innate immune system with a member of this bacterial family, Granulibacter bethesdensis, an emerging pathogen in patients with chronic granulomatous disease (CGD). Efficient phagocytosis of G. bethesdensis by normal and CGD polymorphonuclear leukocytes (CGD PMN) required heat-labile serum components (e.g., C3), and binding of C3 and C9 to G. bethesdensis was detected by immunoblotting. However, this organism survived in human serum concentrations of >90%, indicating a high degree of serum resistance. Consistent with the clinical host tropism of G. bethesdensis, CGD PMN were unable to kill this organism, while normal PMN, in the presence of serum, reduced the number of CFU by about 50% after a 24-h coculture. This finding, together with the observations that G. bethesdensis was sensitive to H 2 O 2 but resistant to LL-37, a human cationic antimicrobial peptide, suggests an inherent resistance to O 2 -independent killing. Interestingly, 10 to 100 times greater numbers of G. bethesdensis were required to achieve the same level of reactive oxygen species (ROS) production induced by Escherichia coli in normal PMN. In addition to the relative inability of the organism to elicit production of PMN ROS, G. bethesdensis inhibited both constitutive and FASinduced PMN apoptosis. These properties of reduced PMN activation and resistance to nonoxidative killing mechanisms likely play an important role in G. bethesdensis pathogenesis. Granulibacter bethesdensis is a Gram-negative pathogen first isolated from a patient with chronic granulomatous disease (CGD) in 2003 (13). G. bethesdensis has since been cultured from at least 5 patients with CGD in the United States (15, 16) and 1 in Spain (23), justifying its classification as an emerging pathogen in this primary immunodeficiency. Although the bacterial family to which G. bethesdensis belongs-the Acetobacteraceae-was previously considered nonpathogenic in humans, case reports of human infections by other members of this family are being published with increasing frequency (1,2,5,6,9,12,17,22,26,27). Common elements of infection by these other Acetobacteraceae species appear to include intravenous drug administration (for either medicinal or recreational purposes), organ transplant, or chronic medical problems requiring dialysis. In contrast, G. bethesdensis has been reported only in patients with CGD, a disease resulting from inadequate superoxide anion production required for normal myeloid host defenses. While G. bethesdensis is the only member of this family for which Koch's postulates have been fulfilled (13), there is scant information about the mechanisms of pathogenesis of infection by these organisms. Although mice with CGD are significantly more susceptible than normal mice to infection by...

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Innate Immunity against Granulibacter bethesdensis, an Emerging Gram-Negative Bacterial Pathogen

et al. 2012

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“…Using the extracted DNA solution as the template for PCR, about a 1,500-bp region of the 16S rRNA gene (16S rDNA) was amplified by PCR using a MicroSeq 16S rDNA Full Gene PCR Kit (Applied Biosystems Japan, Ltd.). PCR products were purified using a QuickStep TR 1 or absence of the amplified fragment and its concentration were determined by electrophoresis using an Agilent Technologies 2100 Bioanalyzer (Agilent Technologies Japan, Ltd., Tokyo). Using this PCR product as the template for the Big-Dye Terminator reaction, sequencing was performed using the MicroSeq 16S rDNA Full Gene Sequencing Kit (Applied Biosystems Japan, Ltd.).…”

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Characteristics of a Pink‐Pigmented Bacterium Isolated from Biofilm in a Cooling Tower in Tokyo, Japan

Furuhata

Goto²,

Kato³

et al. 2007

Microbiology and Immunology

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Strain K‐20, a Gram‐negative, non‐motile, non‐spore‐forming and strictly aerobic rod, which produces a pale pink pigment, was isolated from biofilm in a cooling tower in Tokyo, Japan. The taxonomic feature of the strain was studied using phenotypic tests and phylogenetic analysis. Phylogenetic analysis of 16S rRNA gene sequences showed that the strain was related to Roseomonas gilardii subsp. rosea, Roseomonas gilardii subsp. gilardii, Roseomonas cervicalis and Roseomonas mucosa at 94.3–94.6 sequence similarities. Growth occurred at 25–40 C and pH 5.0–10.0, optimal at 35 C and pH 7.0. Growth did not occur in the presence of ≧2% NaCl. The API 20NE identification system gave a positive result for urease, L‐arabinose, potassium gluconate, adipic acid, malic acid and trisodium citrate (API code number 0201465). The predominant fatty acids of strain K‐20 were C18:1Δ11 (50.8%) and C16:1 (17.2%). Cells contained ubiquinone 10 (Q‐10) as the major quinone and the G+C content was 72.0 mol%. Based on phenotypic, chemotaxonomic and phylogenetic data, it was assumed that strain K‐20 (=JCM 14634) is a novel species of the genus Roseomonas.

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“…1 Rothia dentocariosa has been linked with human disease such as endocarditis, mycotic aneurysms, osteomyelitis, septicaemia, pneumonia, and peritonitis. [2][3][4][5][6][7] Endophthalmitis has been reported in an adult following multiple surgeries. The visual outcome was poor.…”

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Rothia genus endophthalmitis following penetrating injury in a child

Partner

Bhattacharya

Scott

et al. 2005

Eye

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Peritonitis Due to Rothia dentocariosa in a Patient Receiving Continuous Ambulatory Peritoneal Dialysis

Cited by 38 publications

References 0 publications

Innate Immunity against Granulibacter bethesdensis, an Emerging Gram-Negative Bacterial Pathogen

Innate Immunity against Granulibacter bethesdensis, an Emerging Gram-Negative Bacterial Pathogen

Characteristics of a Pink‐Pigmented Bacterium Isolated from Biofilm in a Cooling Tower in Tokyo, Japan

Rothia genus endophthalmitis following penetrating injury in a child

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