Rothia genus endophthalmitis following penetrating injury in a child

Partner, A M; Bhattacharya, Supratik; Scott, Robert A H; Stavrou, P

doi:10.1038/sj.eye.6701902

Cited by 14 publications

(6 citation statements)

References 8 publications

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“…Invasive disease does occur, predominantly in immunocompromised hosts, but has rarely been reported in healthy hosts. The clinical syndromes associated with Rothia infection have included bacteremia (2), endocarditis (3), meningitis (4), peritonitis (5), bone and joint infections (1), pneumonia (6), skin and soft tissue infection, endophthalmitis (7), and prosthetic device infection (3). The main risk factors described for invasive disease have been hematological malignancy and severe neutropenia (8); other risk factors include diabetes mellitus, alcoholism, chronic liver disease, and infection with HIV (3).…”

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confidence: 99%

Rothia Bacteremia: a 10-Year Experience at Mayo Clinic, Rochester, Minnesota

et al. 2014

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Common sources of bacteremia were presumed gut translocation, mucositis, and catheter-related infection. One patient died with Rothia infection. Neutropenic patients were less likely to have a single positive blood culture than were nonneutropenic patients. Antimicrobial susceptibility testing was performed on 21% of the isolates. All of the tested isolates were susceptible to vancomycin and most beta-lactams; however, four of six tested isolates were resistant to oxacillin. There was no difference between the neutropenic and nonneutropenic patients in need of intensive care unit care, mortality, or attributable mortality.

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confidence: 99%

Rothia Bacteremia: a 10-Year Experience at Mayo Clinic, Rochester, Minnesota

et al. 2014

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“…[8]. There is only one report of ocular infection due to this organism in literature in a 11-year-old child who developed exogenous endophthalmitis following penetrating corneal injury [9].…”

Section: Discussionmentioning

confidence: 99%

Endogenous Endophthalmitis in a Two-Week-Old Neonate with Hypofibrinogenemia

Ganesh¹,

Al-Hamhami²,

Mameesh³

et al. 2020

Act Sci Oph

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“…The R. dentocariosa endophthalmitis case reported by MacKinnon et al (2001) was suspected to have arisen endogenously in a 73-year-old male, 1 month following AC reformation with viscoelastic injection. A case of potentially exogenous endophthalmitis caused by an unidentified Rothia species has also been reported, following perforating globe injury [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Rothia dentocariosa endophthalmitis following intravitreal injection—a case report

Hayes

Bennett

O’Hagan

2017

J Ophthal Inflamm Infect

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PurposeThis report describes the first recognised case of Rothia dentocariosa endophthalmitis following intravitreal injection.Case reportA 57-year-old indigenous Australian diabetic female developed pain, redness and decreased vision 3 days after intravitreal aflibercept injection to the right eye—administered for diabetic vitreous haemorrhage with suspected macular oedema and proliferative diabetic retinopathy. Examination revealed best corrected visual acuity (BCVA) of hand movements, ocular hypertension and marked anterior chamber inflammation. The left eye was unaffected but had a BCVA of 6/24 due to pre-existing diabetic retinopathy. Vitreous culture isolated Rothia dentocariosa as the organism responsible for the endophthalmitis. The following treatment with intraocular cephazolin, vancomycin and ceftazidime, topical ciprofloxacin and gentamicin and systemic ciprofloxacin, the patient underwent vitrectomy. Nine weeks after onset, the patient’s BCVA had improved to 6/36, and fundal examination revealed extensive retinal necrosis.Conclusion Rothia dentocariosa is presented as a rare cause of endophthalmitis following intravitreal injection and reports the appearance of ‘pink hypopyon’ previously observed with other organisms. Its identification also demonstrates the risk of oral bacterial contamination during intraocular injections. Vigilance with strategies to minimise bacterial contamination in the peri-injection period are important. Further research to identify additional techniques to prevent contamination with oral bacteria would be beneficial, including whether a role exists for patients wearing surgical masks during intravitreal injections.

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Rothia genus endophthalmitis following penetrating injury in a child

Cited by 14 publications

References 8 publications

Rothia Bacteremia: a 10-Year Experience at Mayo Clinic, Rochester, Minnesota

Rothia Bacteremia: a 10-Year Experience at Mayo Clinic, Rochester, Minnesota

Endogenous Endophthalmitis in a Two-Week-Old Neonate with Hypofibrinogenemia

Rothia dentocariosa endophthalmitis following intravitreal injection—a case report

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