Peritonitis due to <i>Alistipes finegoldii</i> in a patient on peritoneal dialysis

Minguela, José Ignacio; Aurrekoetxea, Begoña; Ferro, Milagros

doi:10.1111/1744-9987.13646

Cited by 4 publications

(1 citation statement)

References 12 publications

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“…The genus Alistipes comprises of 13 species and has been observed to contribute to disease in both clinical and pre‐clinical studies (Parker et al, 2020). While Alistipes has been shown to have protective roles in colitis (Haskey et al, 2023) and Parkinson's disease (Tao et al, 2023), there is also evidence suggesting its potential pathogenicity in diseases such as peritonitis (Minguela et al, 2021), bacteraemia (Cobo et al, 2023) and myalgic encephalomyelitis/chronic fatigue syndrome (Frémont et al, 2013). The genus Holdemanella , which is typically found in the human faecal microbiota (Kageyama & Benno, 2001), exhibits notable concentrations of fatty acids (De Maesschalck et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Exploring the causal relationship between periodontitis and gut microbiome: Unveiling the oral–gut and gut–oral axes through bidirectional Mendelian randomization

Chen,

Peng,

Wang

et al. 2023

J Clinic Periodontology

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AimThis Mendelian randomization (MR) study was performed to explore the potential bidirectional causal relationship between the gut microbiome (GM) and periodontitis.Materials and MethodsWe used genetic instruments from the genome‐wide association study of European descent for periodontitis from the GeneLifestyle Interactions in Dental Endpoints (GLIDE) consortium (17,353 cases and 28,210 controls) and the FinnGen consortium (4434 cases and 259,234 controls) to investigate the causal relationship with GM (the MiBioGen consortium, 18,340 samples), and vice versa. Several MR techniques, which include inverse variance weighting (IVW), MR‐Egger, weighted median, simple mode and weighted mode approaches, were employed to investigate the causal relationship between the exposures and the outcomes. Cochran's Q‐test was performed to detect heterogeneity. The MR‐Egger regression intercept and MR pleiotropy residual sum and outlier test (MR‐PRESSO) were conducted to test potential horizontal pleiotropy. Leave‐one‐out sensitivity analyses were used to assess the stabilities of single nucleotide polymorphisms (SNPs). Finally, the IVW results from the two databases were analysed using meta‐analysis.ResultsWe confirmed three potential causal relationships between GM taxa and periodontitis at the genus level. Among them, the genera Alistipes and Holdemanella were genetically associated with an increased risk of periodontitis. In reverse, periodontitis may lead to a decreased abundance of the genus Ruminococcaceae UCG014.ConclusionsThe demonstration of a causal link between GM and periodontitis provides compelling evidence, highlighting the interconnectivity and interdependence of the gut–oral and oral–gut axes.

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