Bacteremia caused by Alistipes finegoldii in a patient with peritonitis

Cobo, Fernando; Franco-Acosta, Ana; Lara-Oya, Ana; Pérez-Carrasco, Virginia

doi:10.1016/j.eimce.2022.11.002

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…The genus Alistipes comprises of 13 species and has been observed to contribute to disease in both clinical and pre‐clinical studies (Parker et al, 2020). While Alistipes has been shown to have protective roles in colitis (Haskey et al, 2023) and Parkinson's disease (Tao et al, 2023), there is also evidence suggesting its potential pathogenicity in diseases such as peritonitis (Minguela et al, 2021), bacteraemia (Cobo et al, 2023) and myalgic encephalomyelitis/chronic fatigue syndrome (Frémont et al, 2013). The genus Holdemanella , which is typically found in the human faecal microbiota (Kageyama & Benno, 2001), exhibits notable concentrations of fatty acids (De Maesschalck et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Exploring the causal relationship between periodontitis and gut microbiome: Unveiling the oral–gut and gut–oral axes through bidirectional Mendelian randomization

Chen,

Peng,

Wang

et al. 2023

J Clinic Periodontology

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AimThis Mendelian randomization (MR) study was performed to explore the potential bidirectional causal relationship between the gut microbiome (GM) and periodontitis.Materials and MethodsWe used genetic instruments from the genome‐wide association study of European descent for periodontitis from the GeneLifestyle Interactions in Dental Endpoints (GLIDE) consortium (17,353 cases and 28,210 controls) and the FinnGen consortium (4434 cases and 259,234 controls) to investigate the causal relationship with GM (the MiBioGen consortium, 18,340 samples), and vice versa. Several MR techniques, which include inverse variance weighting (IVW), MR‐Egger, weighted median, simple mode and weighted mode approaches, were employed to investigate the causal relationship between the exposures and the outcomes. Cochran's Q‐test was performed to detect heterogeneity. The MR‐Egger regression intercept and MR pleiotropy residual sum and outlier test (MR‐PRESSO) were conducted to test potential horizontal pleiotropy. Leave‐one‐out sensitivity analyses were used to assess the stabilities of single nucleotide polymorphisms (SNPs). Finally, the IVW results from the two databases were analysed using meta‐analysis.ResultsWe confirmed three potential causal relationships between GM taxa and periodontitis at the genus level. Among them, the genera Alistipes and Holdemanella were genetically associated with an increased risk of periodontitis. In reverse, periodontitis may lead to a decreased abundance of the genus Ruminococcaceae UCG014.ConclusionsThe demonstration of a causal link between GM and periodontitis provides compelling evidence, highlighting the interconnectivity and interdependence of the gut–oral and oral–gut axes.

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Section: Discussionmentioning

confidence: 99%

Exploring the causal relationship between periodontitis and gut microbiome: Unveiling the oral–gut and gut–oral axes through bidirectional Mendelian randomization

Chen,

Peng,

Wang

et al. 2023

J Clinic Periodontology

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Retrospective Study of Bacteremia Caused byAlistipesSpecies in Japan, 2016–2023

Watanabe,

Watari,

Hosokawa

et al. 2024

Preprint

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The clinical characteristics ofAlistipesbacteremia remain insufficiently described. Therefore, here, we retrospectively analyzed 13 cases ofAlistipesbacteremia at a tertiary care center to evaluate their clinical and microbiological characteristics. Ten patients were aged ≥ 65 years, and seven were female. Nine patients had comorbidities, including seven with solid tumors or hematological malignancies. Eleven patients presented with gastrointestinal symptoms. The isolates included fourAlistipes finegoldii, fourAlistipes onderdonkii, threeAlistipes putredinis, twoAlistipes indistinctus, and oneAlistipes ihumiiisolates. Ten available strains exhibited low minimum inhibitory concentrations against β-lactam/β-lactamase inhibitors and metronidazole, whereas they exhibited high minimum inhibitory concentrations for penicillin, ceftriaxone, and minocycline. Several strains harbored antimicrobial resistance genes, includingadeF,tet(Q),cfxA3,cfxA4, anderm(G). Twelve patients received β-lactam/β-lactamase inhibitors, and two elderly patients with solid tumors developed septic shock and died.Alistipesspecies can translocate from the gastrointestinal tract into the bloodstream, leading to severe infections.

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Bacteremia caused by Alistipes finegoldii in a patient with peritonitis

Cited by 2 publications

References 7 publications

Exploring the causal relationship between periodontitis and gut microbiome: Unveiling the oral–gut and gut–oral axes through bidirectional Mendelian randomization

Exploring the causal relationship between periodontitis and gut microbiome: Unveiling the oral–gut and gut–oral axes through bidirectional Mendelian randomization

Retrospective Study of Bacteremia Caused byAlistipesSpecies in Japan, 2016–2023

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