Peritonitis

Bentley, Adrienne M.

doi:10.1002/9781118487181.ch8

Cited by 2 publications

(9 citation statements)

References 117 publications

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“…This result is consistent with the result of Dehgani et al's study (2000), who conducted similar work in Iranian goats, which is possibly attributed to the ongoing aseptic peritonitis as a result of mechanical abrasion and desiccation of the peritoneum [10,16,29]. Furthermore, leukocytosis, neutrophilia, and lymphocytopenia are usually observed in less severe acute peritonitis [12,14,18,19,21,29,33].…”

Section: Discussionsupporting

confidence: 90%

Hematological prediction study of peritonitis following laparotomy in goats

et al. 2020

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Surgical trauma to the abdominal wall and peritoneum during celiotomy is expected to cause postoperative inflammation. However, complications after abdominal surgery are hardly detected in the early stage. Hematological analysis of blood has been considered beneficial in disease diagnosis and prognosis. This study aimed to evaluate the hematological parameters predicting peritonitis in goats and to determine the post-surgery day that hematology is significant. Six apparently healthy West African Dwarf goats were included in this study. After 2 weeks of acclimatization, blood samples were obtained daily for 3 days for hematological analyses, which served as the baseline data. The right flanks of the animals were aseptically prepared routinely for exploratory laparotomy. Restraint and anesthesia were achieved using xylazine and lignocaine using an inverted "L" block technique. Laparotomy was performed, and the incision was left for 20 min and then closed routinely. Blood samples were collected for hemogram 24 hr postoperatively and daily for 7 days. Based on the post-surgery hematology results, relative neutrophil (P=0.015) and lymphocyte (P=0.006) counts significantly increased and decreased on day 5 respectively. Significant differences were also observed for red blood cell count, hemoglobin concentration, and packed cell volume on days 5, 6, and 7 respectively. It could therefore be concluded that the diagnostic result for hematology post-laparotomy can be obtained on the fifth and sixth day.

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Section: Discussionsupporting

confidence: 90%

Hematological prediction study of peritonitis following laparotomy in goats

et al. 2020

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“…30,31 Septic shock associated with a gastroduodenal perforation can further compound hypotension and decrease tissue oxygen delivery through the redistribution of the circulatory system to critical organs. 4,6,32 Adequate blood supply is one of the most important factors to successful anastomosis healing and in cases of either shock or hypotension this is significantly decreased and therefore a higher risk for failure and mortality exists. 4,15,25,33 Results of this study identified a trend between hyperlactatemia at presentation and postoperative mortality.…”

Section: Discussionmentioning

confidence: 99%

“…8 Sequelae to full thickness gastroduodenal perforations include shock and septic peritonitis, both of which are life-threatening complications. [4][5][6] The variability of gastrointestinal ulcerations between dogs receiving similar doses of NSAIDs remains poorly understood. Nonsteroidal anti-inflammatory drugs inhibit the cyclooxygenase (COX) enzyme, which is activated during tissue injury.…”

Section: Introductionmentioning

confidence: 99%

“…Nonsteroidal anti‐inflammatory treatment is the most common predisposing factor in dogs 8 . Sequelae to full thickness gastroduodenal perforations include shock and septic peritonitis, both of which are life‐threatening complications 4–6 …”

Section: Introductionmentioning

confidence: 99%

“…Gastroduodenal ulcerations leading to full thickness perforation and septic peritonitis have been well documented in the veterinary literature and are often considered surgical emergencies. [1][2][3][4][5][6] Predisposing factors to full thickness perforation include hepatic disease and nonsteroidal anti-inflammatory drug (NSAID) administration. 2,3,7 Nonsteroidal anti-inflammatory treatment is the most common predisposing factor in dogs.…”

Section: Introductionmentioning

confidence: 99%

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Primary repair of nonsteroidal anti‐inflammatory drug‐associated full thickness gastrointestinal ulcers in 11 dogs

et al. 2022

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Objective To report the outcomes of dogs that underwent primary repair of gastroduodenal perforations associated with the administration of nonsteroidal anti‐inflammatory drugs (NSAID). A secondary objective was to identify clinicopathological findings that predisposed dogs to postoperative death. Study design Retrospective study. Animals Eleven dogs with complete gastric or duodenal perforation related to administration of an NSAID that underwent primary surgical repair. Methods Medical records were reviewed for dogs that presented with peritonitis due to a complete gastroduodenal perforation while receiving NSAIDs between November, 2011 and January, 2021. Data collected included patient characteristics, clinical signs, clinicopathological results, surgical details, and postoperative management and outcome. Results All dogs were large breeds (mean weight 42 kg; range 22‐75 kg), with a mean age of 7.35 years. Nine dogs from a total of 11 (82 %) received a concurrent corticosteroid and NSAID, or a higher dose/frequency/length of NSAID administration than recommended by the manufacturer. All gastroduodenal perforations were found in the upper gastrointestinal tract. Eight of 11 (73%) dogs survived to discharge. The median postoperative duration of follow up was 444 days (range 2‐1460 days). No association was detected between ulcer size or location and mortality. Conclusion Most dogs who underwent primary repair of complete gastroduodenal ulcers survived. Gastroduodenal perforations were generally due to the administration of higher or longer doses of NSAIDs, or concurrent administration of another NSAID or corticosteroid. Clinical significance Primary closure may be associated with a high success rate in dogs with full thickness gastroduodenal ulcers.

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Peritonitis

Cited by 2 publications

References 117 publications

Hematological prediction study of peritonitis following laparotomy in goats

Hematological prediction study of peritonitis following laparotomy in goats

Primary repair of nonsteroidal anti‐inflammatory drug‐associated full thickness gastrointestinal ulcers in 11 dogs

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