Peritoneal healing and adhesion formation/reformation

Cheong, Ying; Laird, Susan; Li, Tin‐Chiu; Shelton, J. B.; Ledger, William; Cooke, I. D.

doi:10.1093/humupd/7.6.556

Cited by 307 publications

(274 citation statements)

References 100 publications

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“…Intra-abdominal infections and subsequent peritonitis are associated with fibrin deposits, which may cause clinically significant adhesion and abscess formation. [13,14] We used the CLP model to simulate this clinical situation. No systemic antibiotic was administrated in our study in order to specifically evaluate the local effects of the antibiotics.…”

Section: Discussionmentioning

confidence: 99%

Effect of Antibiotic Lavage in Adhesion Prevention in Bacterial Peritonitis.

Kayaoğlu¹,

Özkan²,

Yenidoğan³

et al. 2013

Ulus Travma Acil Cerrahi Derg

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Section: Discussionmentioning

confidence: 99%

Effect of Antibiotic Lavage in Adhesion Prevention in Bacterial Peritonitis.

Kayaoğlu¹,

Özkan²,

Yenidoğan³

et al. 2013

Ulus Travma Acil Cerrahi Derg

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“…It is likely that the activity of cellular mediators in the peritoneal fluid plays an active role in peritoneal healing. These cellular mediators are produced by the cellular components of the peritoneal fluid such as the mast cells, the macrophages, the neutrophils and the eosinophils [10,11]. Surgical trauma triggers inflammation process which causes an increase in vascular permeability and release of fibrinrich exudates [12].…”

Section: Discussionmentioning

confidence: 99%

“…If the fibrin is not lysed through the plasminogen-plasmin cascade, adhesions may form through collagen deposition on a framework of proteoglycan and fibronectin [13]. Plasmin can be produced by macrophages or by mesothelial cells lining the peritoneal cavity [10]. The main role of plasmin is to degrade fibrin.…”

Section: Discussionmentioning

confidence: 99%

Mast cells in peritoneal fluid in rats with experimentally induced peritoneal adhesions.

Hermanowicz

Dębek²,

Oksiuta³

et al. 2010

Folia Histochem Cytobiol.

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Mast cells (MC) produce, store and release many biologically active substances, especially inflammatory factors, chemotactic substances for neutrophiles, cytokines and prostaglandins. They play very important role in fibrinosis and they are an important factor in peritoneal adhesions formation and lysis. In this study we tried to evaluate role of mast cells in peritoneal adhesions formation. We estimated number of mast cells in peritoneal fluid in rats with experimentally developed peritoneal adhesions. The number of mast cells per ml was counted in flow cytometry in specimens of peritoneal fluid taken from operated rats. The fluid was taken in standarized conditions the same for each group at the first operation and during reoperation. Peritoneal cavity was washed with 0.9% Saline solution. MC were visualized using indirect immunohistochemical method LSAB with mouse antibody. The animals were divided into 4 groups. 1 st group was control group (n=20) on which the abdomen was opened and closed without any manipulations, and the reoperation was done after 72 hours. The other groups (2, 3, 4; n=20 for each group) were operated and scarification of the partial peritoneum and serosa was performed. The rats were brought back to conscious and then were reoperated respectively after 24, 72 and 168 hours after first surgery. After the laparotomy and damage of the peritoneum we observed formation of the peritoneal adhesions between intestine loops and between intestines and damaged parietal peritoneum. Also the higher number of mast cells was observed in the groups of animals with damaged peritoneum. The highest number of peritoneal adhesions was observed in the group of animals reoperated after 72 hours. After 72 and 168 hours the higher number of MC and neutrophils was observed. The difference was statistically significant. The percentage of mast cells was increasing during the experiment duration. It was different from other cells populations which decreased after 168 hours. The MC and neutrophils were cell population which changed significantly after manipulations in peritoneal cavity. It is very probable that they play an important role in peritoneal adhesions formation.

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“…However, evidence suggests that three basic processes are involved: (i) the acute inflammatory response, (ii) the fibrinolytic cascade, and (iii) extracellular matrix remodeling (Cheong et al, 2001). Several therapeutic strategies have been used to prevent adhesion formation, including surgical techniques.…”

Section: Introductionmentioning

confidence: 99%

Use of N,O-carboxymethyl chitosan to prevent postsurgical adhesions in a rabbit double uterine horn model: a randomized controlled design

Ren

Zhao

Zhu

2016

Sci. China Life Sci.

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In previous studies, N,O-carboxymethyl chitosan has been shown to decrease the incidence and intensity of abdominal adhesions. In the present study, adhesions were induced in 220 rabbits using a double uterine horn model. Rabbits were randomized to receive an operation only or an operation+medical chitosan intraperitoneally. Twenty-two rabbits from each group were euthanized at one of five different times (Day 3, 7, 14, 28, or 42), and adhesion formation was given gross and histopathological scores. Reductions were observed in adhesion extent (P=0.0337) and tenacity (P=0.0271) as well as inflammation (P<0.0001) on Day 3 when medical chitosan was applied. Prior to Day 14, fibrosis was less obvious in the medical chitosan group (P<0.0005). The tenacity scores were significantly lower in the medical chitosan group following Day 14 (P<0.05), while the type scores were lower in the medical chitosan group following Day 28 (P<0.03). Thus, medical chitosan decreased both the gross and the histopathological scores of the induced adhesions.

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Peritoneal healing and adhesion formation/reformation

Cited by 307 publications

References 100 publications

Effect of Antibiotic Lavage in Adhesion Prevention in Bacterial Peritonitis.

Effect of Antibiotic Lavage in Adhesion Prevention in Bacterial Peritonitis.

Mast cells in peritoneal fluid in rats with experimentally induced peritoneal adhesions.

Use of N,O-carboxymethyl chitosan to prevent postsurgical adhesions in a rabbit double uterine horn model: a randomized controlled design

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