Effect of Antibiotic Lavage in Adhesion Prevention in Bacterial Peritonitis.

Kayaoğlu, Hüseyin Ayhan; Özkan, Nilüfer; Yenidoğan, Erdinç; Köseoğlu, Reşit Doğan

doi:10.5505/tjtes.2013.63444

Cited by 12 publications

(14 citation statements)

References 23 publications

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“…Another experimental study was carried out to test the effectiveness of the intraperitoneal application of alternate antibiotics (Imipenem, ceftriaxone, and cefazolin) in an abdominal sepsis model. These data suggest that cephalosporins may be effective in preventing adhesion formation in septic abdomens compared to metronidazole [46].…”

Section: Resultsmentioning

confidence: 80%

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Intraoperative surgical site infection control and prevention: a position paper and future addendum to WSES intra-abdominal infections guidelines

Simone¹,

Sartelli

Coccolini

et al. 2020

World J Emerg Surg

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Background: Surgical site infections (SSI) represent a considerable burden for healthcare systems. They are largely preventable and multiple interventions have been proposed over past years in an attempt to prevent SSI. We aim to provide a position paper on Operative Room (OR) prevention of SSI in patients presenting with intraabdominal infection to be considered a future addendum to the well-known World Society of Emergency Surgery (WSES) Guidelines on the management of intra-abdominal infections. Methods: The literature was searched for focused publications on SSI until March 2019. Critical analysis and grading of the literature has been performed by a working group of experts; the literature review and the statements were evaluated by a Steering Committee of the WSES.Results: Wound protectors and antibacterial sutures seem to have effective roles to prevent SSI in intra-abdominal infections. The application of negative-pressure wound therapy in preventing SSI can be useful in reducing postoperative wound complications. It is important to pursue normothermia with the available resources in the intraoperative period to decrease SSI rate. The optimal knowledge of the pharmacokinetic/pharmacodynamic characteristics of antibiotics helps to decide when additional intraoperative antibiotic doses should be administered in patients with intra-abdominal infections undergoing emergency surgery to prevent SSI.Conclusions: The current position paper offers an extensive overview of the available evidence regarding surgical site infection control and prevention in patients having intra-abdominal infections.

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Section: Resultsmentioning

confidence: 80%

“…Animal data about the relationship between intraperitoneal antibiotics and adhesion development are conflicting [42][43][44][45][46].…”

Section: Resultsmentioning

confidence: 99%

Intraoperative surgical site infection control and prevention: a position paper and future addendum to WSES intra-abdominal infections guidelines

Simone¹,

Sartelli

Coccolini

et al. 2020

World J Emerg Surg

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“…Moxifloxacin, used as monotherapy, has been beneficial in secondary severe intra-abdominal sepsis with high clinical and bacteriological efficacies in hospitalized patients; even with polyorganic insufficiency 7 .This fourth generation fluor quinolone promotes control of sepsis and septic-shock and has a good penetration from the blood into the peritoneal cavity, aiming to control severe peritonitis [21][22][23][24][25][26] . However, its use inside the peritoneal cavity has not yet been tested.…”

Section: Discussionmentioning

confidence: 99%

Severe autogenously fecal peritonitis in Wistar rats with permanent bilateral carotid occlusion. Response to intra peritoneal moxifloxacin combined with dexamethasone

Melo

Gadelha²,

Oliveira

et al. 2014

Acta Cir. Bras.

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PURPOSE:To evaluate the treatment outcome of severe peritonitis in rats submitted to permanent bilateral carotid occlusion (PBCO). METHODS:Sixteen Wistar rats (mean age of 8.5 months) with PBCO underwent autogenously fecal peritonitis, and were treated with moxifloxacin combined with dexamethasone, and followed-up for 45 days. Ten rats (mean age five months) without PBCO were used as a control group. The variables were expressed by their mean and standard error of the mean (SEM). p<0.05 was used for rejecting the null hypothesis. The study was approved by the Ethics Committee. RESULTS:There was a significant increase (p=0.0002) in the mortality and morbidity in older rats that underwent PBCO (study group). However, even among the survival rats presenting with severe residual abscesses both in the abdomen and thorax cavities, they present an almost normal life. CONCLUSIONS:The treatment of severe autogenously fecal peritonitis with intraperitoneal moxifloxacin combined with dexamethasone was very effective in young rats without permanent bilateral carotid occlusion. The treatment reached reasonable results in older rats with PBCO, even considering residual abscesses on abdomen and thorax. Older age was the greater risk factor for the outcome of the treatment of severe peritonitis. Sepsis remains a challenging situation, especially in elderly.Key words: Peritonitis. Quinolones. Dexamethasone. Therapy. Rats. Severe autogenously fecal peritonitis in Wistar rats with permanent bilateral carotid occlusion.Response to intra peritoneal moxifloxacin combined with dexamethasone

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“…On the other hand, saline is used generally as control in the peritoneal adhesion models of intraabdominal medication. When saline lavage or installation is included into the experimental groups, three different results are observed; beneficial, [10][11][12][13][14] ineffective, [9,[15][16][17][18] or even harmful. [19,20] Another challenge in peritoneal adhesion studies is the use of several different models.…”

Section: Discussionmentioning

confidence: 99%

Effects of saline lavage temperature on peritoneal fibrinolysis and adhesion formation

Koca

Tarhan

Kaya

et al. 2015

Ulus Travma Acil Cerrahi Derg

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Effect of Antibiotic Lavage in Adhesion Prevention in Bacterial Peritonitis.

Cited by 12 publications

References 23 publications

Intraoperative surgical site infection control and prevention: a position paper and future addendum to WSES intra-abdominal infections guidelines

Intraoperative surgical site infection control and prevention: a position paper and future addendum to WSES intra-abdominal infections guidelines

Severe autogenously fecal peritonitis in Wistar rats with permanent bilateral carotid occlusion. Response to intra peritoneal moxifloxacin combined with dexamethasone

Effects of saline lavage temperature on peritoneal fibrinolysis and adhesion formation

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