Peritoneal Dialysis for the Removal of Protein‐Bound Markers of Hepatic Insufficiency

Abstract

The addition of human serum albumin (HSA) to peritoneal dialysate increases the clearance of bilirubin in rats suffering from obstructive jaundice. The acceptor properties of the fluid can be enhanced by using HSA that does not contain standard stabilizing additives and has been purified by further adsorption on activated carbon. Bilirubin‐containing dialysate fluid, as well as the ascitic fluid of cirrhotic patients, can be regenerated by a combination of membrane ultrafiltration and carbon adsorption. These observations suggest a potentially useful scheme for continuous, regenerative peritoneal dialysis in the treatment of hepatic insufficiency.

Surface modification of ultrahigh molecular weight polyethylene by the poly(ethylene glycol)‐grafted method and its effect on the adsorption of proteins and the adhesion of blood platelets

“…On one hand, many purely artificial systems have been investigated over the past 30 years (4−8), and the most recent developments appear promising (9−11). Nevertheless, liver functions are multiple and complex (detoxification, transformation, synthesis), and one can doubt the efficiency of mechanical or chemical forces to replace all of them (12).…”