A review of bioartificial liver development from an artificial organ engineering perspective

Smith, Mark D.; Grant, M.H.; Cousins, Rod B.; Gaylor, J.D.S.

doi:10.1007/978-94-017-3345-8_30

Cited by 3 publications

(2 citation statements)

References 61 publications

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“…Many laboratories have attempted to harness the proliferation potential of hepatocytes to obtain their expansion in culture, with specially elaborated media and culture conditions [9, –11] to study metabolic processes, including metabolism of xenobiotics [12], and to develop bioartificial liver devices [13] and in vitro models for infection by hepatotropic viruses and parasites [14, 15]. The attempts have been at least partially thwarted by the fact that proliferation and differentiation of hepatocytes in culture appear to be mutually exclusive [9, 11].…”

Section: Introductionmentioning

confidence: 99%

Plasticity of Hepatic Cell Differentiation: Bipotential Adult Mouse Liver Clonal Cell Lines Competent to Differentiate In Vitro and In Vivo

Fougère-Deschatrette¹,

Imaizumi-Scherrer²,

Strick‐Marchand³

et al. 2006

STEM CELLS

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Section: Introductionmentioning

confidence: 99%

Plasticity of Hepatic Cell Differentiation: Bipotential Adult Mouse Liver Clonal Cell Lines Competent to Differentiate In Vitro and In Vivo

Fougère-Deschatrette¹,

Imaizumi-Scherrer²,

Strick‐Marchand³

et al. 2006

STEM CELLS

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“…In stacked plate reactors, large surface area is obtained by alternately stacking flat membranes and spacers. In recent in vitro studies 42,43 cells were cultured on oxygenation membranes in monolayers or flat sheets to try to mimic liver structure. Perfusate through the spaces between membranes directly contacted the cells.…”

Section: Examples Of Bioartificial Liver Reactorsmentioning

confidence: 99%

Overview of Extracorporeal Liver Support Systems and Clinical Results

McLAUGHLIN

Tosone

Custer

et al. 1999

Annals of the New York Academy of Sciences

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Patients with acute liver failure (ALF) continue to have an almost 50% mortality rate despite improvements associated with the use of orthotopic liver transplantation (OLT). Numerous ex vivo methods have been developed in attempts to improve patient survival. These methods can be divided into three groups: detoxification (e.g., dialysis, charcoal adsorption, plasma exchange), which only provides excretory function; ex vivo liver perfusion (e.g., whole organ or tissue perfusion), which provides some metabolic function; and bioartificial or cell-based systems, which combine elements of the first two methods. Clinical trials have shown minimal efficacy of the various detoxification methods in terms of ALF patient survival, while the relative success of OLT has shown the importance of providing metabolic as well as excretory functions. Attempts to provide those additional functions with ex vivo tissue perfusion have been fraught with complications such as clotting and acute tissue rejection, leading to the conceptual development of cell-based bioreactor systems. A number of these bioartificial systems have been clinically evaluated, and the preliminary patient survival rates have encouraged further work in this area.

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Cryopreservation of Hepatocytes for Bioartificial Liver Devices

Stevenson

Grant

2005

Bioreactors for Tissue Engineering

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A review of bioartificial liver development from an artificial organ engineering perspective

Cited by 3 publications

References 61 publications

Plasticity of Hepatic Cell Differentiation: Bipotential Adult Mouse Liver Clonal Cell Lines Competent to Differentiate In Vitro and In Vivo

Plasticity of Hepatic Cell Differentiation: Bipotential Adult Mouse Liver Clonal Cell Lines Competent to Differentiate In Vitro and In Vivo

Overview of Extracorporeal Liver Support Systems and Clinical Results

Cryopreservation of Hepatocytes for Bioartificial Liver Devices

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