Peritoneal Cytology in Endometrial Cancer

Çetinkaya, Kadir; Atalay, Funda

doi:10.5301/tj.5000403

Cited by 7 publications

(3 citation statements)

References 15 publications

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“…Of these, 59 articles were excluded regarding eligibility criteria, and 21 articles were not included due to unavailability of full-texts (Figure 1). Finally, 65 papers were included for qualitative analysis which were retrospective observational studies and were published from 1981 to 2020 (7,9,11,14,19–77). The details of these studies are also presented in Appendix 1.…”

Section: Resultsmentioning

confidence: 99%

“…Of these 65 studies, 27 papers met the criteria for meta-analysis, which included an overall number of 75897 patients. Of the 27 papers, 16 studies (11,13,21,22,24,35,36,43,49,54,58,62,68,70,73,77) included OS data, 18 had DFS data(14,21,62,64,68,70,72,74,77,78,25,36,39,43,44,49,53,58), and 7 had CSS(7)(19)(33)(44)(45)(64)(73). The quality assessment (QUIPS) of included studies is summarized in table 1.…”

Section: Resultsmentioning

confidence: 99%

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Survival rate of positive peritoneal cytology in endometrial cancer; a systematic review and meta-analysis

Dehghan

Binesh

Moravej

et al. 2022

Preprint

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BackgroundThe impact of positive peritoneal cytology on survival rate of endometrial cancer patients in different stages and histopathology is still controversial. We performed a systematic review and meta-analysis to investigate the influence of positive peritoneal cytology (PPC) on survival rate of patients with endometrial carcinoma.MethodsA systematic literature search of PubMed, Embase, Scopus, and Cochrane databases was conducted up to November 24, 2020. The quality of included studies was evaluated by Quality in prognosis study (QUIPS) tool.ResultsInitially, 3014 articles were found, of which 65 met the inclusion criteria for qualitative analysis and 27 studies on 75897 patients with endometrial cancer were included in the meta-analysis. PPC was associated with a lower overall survival in endometrial cancer (HR= 2.102; 95% CI:1.629-2.711; P< 0.001). The findings also identified PPC as an independent prognostic factor for both disease-free survival (HR= 3.052; 95% CI: 2.348-2967; P< 0.001) and cancer specific survival (HR= 3.461; 95% CI: 2.280-5.254; P< 0.001). In addition, we meta-analyzed the studies in 21 subgroups based on staging and histopathology of the endometrial cancer which all identified PPC as a non-prognostic factor for cancer of endometrium.ConclusionPPC is an independent prognostic factor for endometrial cancer survival rate in all staging and histopathologic subgroups.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Survival rate of positive peritoneal cytology in endometrial cancer; a systematic review and meta-analysis

Dehghan

Binesh

Moravej

et al. 2022

Preprint

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“…Elthabbakh et al, in a prospective study, reported that laparoscopic surgery does not increase the positive peritoneal cytology in women with endometrial carcinoma (10), but its clinical significance remained controversial (11)(12)(13). Besides, the lymph vascular space invasion (LVSI) has been recognized to be an independent risk factor for pelvic lymph node recurrence, and it is found in about 15% of low-risk endometrial cancer patients (14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

A Multicentric Randomized Trial to Evaluate the ROle of Uterine MANipulator on Laparoscopic/Robotic HYsterectomy for the Treatment of Early-Stage Endometrial Cancer: The ROMANHY Trial

et al. 2021

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ObjectiveThis prospective randomized trial aimed to assess the impact of the uterine manipulator in terms of lymph vascular space invasion (LVSI) in patients undergoing minimally invasive staging for early-stage endometrial cancer.MethodsIn this multicentric randomized trial, enrolled patients were randomly allocated in two groups according to the no use (arm A) or the use (arm B) of the uterine manipulator. Inclusion criteria were G1-G2 early-stage endometrial cancer at preoperative evaluation. The variables collected included baseline demographic characteristics, perioperative data, final pathology report, adjuvant treatment, and follow-up.ResultsIn the study, 154 patients (76 in arm A and 78 in arm B) were finally included. No significant differences were recorded regarding the baseline characteristics. A statistically significant difference was found in operative time for the laparoscopic staging (p=0.005), while no differences were reported for the robotic procedures (p=0.419). The estimated blood loss was significantly lower in arm A (p=0.030). No statistically significant differences were recorded between the two study groups in terms of peritoneal cytology, LVSI (p=0.501), and pattern of LVSI (p=0.790). No differences were detected in terms of overall survival and disease-free survival (p=0.996 and p=0.480, respectively). Similarly, no differences were recorded in the number of recurrences, 6 (7.9%) in arm A and 4 (5.2%) in arm B (p=0.486). The use of the uterine manipulator had no impact on DFS both at univariable and multivariable analyses.ConclusionsThe intrauterine manipulator does not affect the LVSI in early-stage endometrial cancer patients undergoing laparoscopic/robotic staging.Clinical Trial Registrationhttps://clinicaltrials.gov, identifier (NCT: 02762214)

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Special Considerations for Peritoneal Washings

VandenBussche

Crothers

Fader

et al. 2020

The International System for Serous Fluid Cytopathology

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Peritoneal Cytology in Endometrial Cancer

Abstract: Positive peritoneal cytology has a significant effect on survival in endometrial cancer. Positive peritoneal cytology occurrence is influenced by myometrial invasion, cervical stromal invasion, tumor size, histologic type, and lymphatic metastasis.

Cited by 7 publications

References 15 publications

Survival rate of positive peritoneal cytology in endometrial cancer; a systematic review and meta-analysis

Survival rate of positive peritoneal cytology in endometrial cancer; a systematic review and meta-analysis

A Multicentric Randomized Trial to Evaluate the ROle of Uterine MANipulator on Laparoscopic/Robotic HYsterectomy for the Treatment of Early-Stage Endometrial Cancer: The ROMANHY Trial

Special Considerations for Peritoneal Washings

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