Special Considerations for Peritoneal Washings

VandenBussche, Christopher; Crothers, Barbara A.; Fader, Amanda N.; Jackson, Amanda; Zhao, Chengquan

doi:10.1007/978-3-030-53908-5_9

Cited by 2 publications

(4 citation statements)

References 123 publications

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“…These features lie in direct contrast to the large, complex papillary structures with profound cellular tufting and moderate to severe cytologic atypia seen in serous neoplasms. Notably, these structures may be seen in women of any age and, as an isolated finding, are more commonly seen in postmenopausal patients [1].…”

Section: Endosalpingiosismentioning

confidence: 99%

“…Acellular, extracellular mucinous material may occasionally be observed in the background of pelvic washing specimens, raising concern for a mucin-producing neoplasm [1,33,34]; however, the lack of increased cellularity and cytologic atypia in these specimens allows exclusion of this possibility. This finding has previously been described and the source of contamination identified as surgical collection devices, specifically suction canister liner bags.…”

Section: Acellular Mucinmentioning

confidence: 99%

“…Cytologic findings in fluid specimens from patients with gynecologic tract disease may have a significant impact on tumor staging, treatment, and prognosis [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

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Cytology of Benign Peritoneal Fluids and Pelvic Washing Specimens: Diagnostic Cytomorphologic Features and Pitfalls

Song

2023

Acta Cytologica

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Background: Pelvic washing and peritoneal fluid cytology specimens are used to detect peritoneal spread of malignancies. In most cases, identification of malignancy in these specimens is straightforward, but benign processes may occasionally mimic neoplasia and cause diagnostic difficulty. Summary: In this article, we perform a focused review of common benign entities encountered in pelvic washing and peritoneal fluid specimens during routine practice which may cause difficulty and discuss helpful features for avoiding diagnostic pitfalls. Key Messages: Application of strict cytomorphologic criteria, along with judicious use of ancillary studies and correlation with clinical, intraoperative, radiologic, and other pathologic findings, can help resolve most problematic cases.

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Section: Endosalpingiosismentioning

confidence: 99%

Section: Acellular Mucinmentioning

confidence: 99%

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Cytology of Benign Peritoneal Fluids and Pelvic Washing Specimens: Diagnostic Cytomorphologic Features and Pitfalls

Song

2023

Acta Cytologica

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“…One such prognostic factor may be malignant peritoneal cytology, which was an element of the Fédération internationale de gynécologie et d'obstétrique (FIGO) cancer staging system before the 2009 revision [7]. Peritoneal wash cytology is a diagnostic technique based on the detection of cancer cells that are shed from the primary focus and spread into the abdomen [8]. Although peritoneal cytology has been removed from the endometrial cancer staging system, National Comprehensive Cancer Network (NCCN) guidelines continue to recommend the evaluation of peritoneal cytology [9].…”

Section: Introductionmentioning

confidence: 99%

The Role of Lymphovascular Space Invasion and Cytology in the Prognosis of Endometrial Cancer

Ozdemir,

Arioz,

Celik

et al. 2024

Discovery Medicine

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Background: Lymphovascular space invasion (LVSI) and cytology are both independent and strong prognostic factors in endometrial cancer. This study aims to highlight the impact of LVSI and cytology positivity on prognosis, in addition to molecular classification. Methods: A retrospective review was conducted on the records of 223 patients with endometrial cancer diagnosed between January 2011 and January 2021. The inclusion criteria stipulated that the patients were diagnosed with endometrial cancer by endometrial biopsy and were operated in the clinic. The exclusion criteria included sarcoma in the postoperative pathology report results or synchronous tumor. Staging was performed according to the Fédération internationale de gynécologie et d'obstétrique (FIGO) 2009 criteria. Cytology (using 50 cc saline) was obtained upon entry into the peritoneal cavity. In 20 patients, saline was not used due to the presence of ascites in the abdomen. The Kaplan-Meier method was employed to evaluate overall survival and progression-free survival. Survival rates were compared in terms of cytology and LVSI. Results: After analyzing the postoperative pathology results, it was found that the mean tumor size was 4.03 ± 2.3 cm. The most common histological type was endometrioid carcinoma, with stage IA being the most common stage. Out of 223 patients with endometrial cancer, the overall survival rate was 82.4%, and the progression-free survival rate was 88.3%. For patients negative for LVSI, the progression-free survival rate was 93%, while for LVSI-positive patients, it was 77.3% (p < 0.001). Additionally, the progression-free survival rate for patients negative for cytology was 90.4%, whereas for cytology-positive patients, it was 77.1% (p < 0.05). Conclusions: In our study, we observed that LVSI positivity and cytology positivity also reduced the overall survival rate. We aimed to highlight that, in addition to molecular classification, cytology positivity and LVSI positivity are still highly significant and independent factors in prognosis.

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Special Considerations for Peritoneal Washings

Cited by 2 publications

References 123 publications

Cytology of Benign Peritoneal Fluids and Pelvic Washing Specimens: Diagnostic Cytomorphologic Features and Pitfalls

Cytology of Benign Peritoneal Fluids and Pelvic Washing Specimens: Diagnostic Cytomorphologic Features and Pitfalls

The Role of Lymphovascular Space Invasion and Cytology in the Prognosis of Endometrial Cancer

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