Perirenal Fat Thickness: A Surrogate Marker for Metabolic Syndrome in Chinese Newly Diagnosed Type 2 Diabetes

Guo, Xiu Li; Tu, Mei; Chen, Yang; Wang, Wei

doi:10.3389/fendo.2022.850334

Cited by 9 publications

(12 citation statements)

References 33 publications

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“…In the subgroup analysis, Pearson correlation analysis showed that the relationship between PrFT and PnFT and SUA in males was stronger than that in females. While another study conducted by Guo et al presented a higher correlation between PrFT and SUA in females [ 24 ].That study enrolled patients with newly diagnosed T2DM and with mean age of 52.5 ± 8.2 years, which may explain the contrary results. In addition, we also found that the relationship between PrFT and PnFT and SUA was not significant in patients with reduced renal function.…”

Section: Discussionmentioning

confidence: 98%

“…The main finding of our study was that the PrFT was independently and positively associated with SUA level in patients with T2DM. As previous studies reported, PrFT and PnFT were positively associated with SUA respectively in diabetic patients [ 19 , 24 ], while some confounders were not adjusted. Similarly, Lamacchia et al and Giulio et al reported that para-and perirenal fat thickness was significantly and positively associated with SUA in diabetic patients and hypertensive patients respectively [ 23 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

“…Few studies explored the relationship between perirenal fat and paranephric fat and SUA level. Some cross-sectional studies have shown that perirenal fat thickness (PrFT) and paranephric fat thickness (PnFT) were both positively related to SUA in diabetic patients in univariate analysis [ 19 , 24 ]. Another study reported that para-perirenal fat thickness was an independent predictor of SUA level in diabetic patients after adjustment for traditional metabolic factors, while did not distinguish PrFT from PnFT [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

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The perirenal fat thickness was independently associated with serum uric acid level in patients with type 2 diabetes mellitus

Yang

Cheng

et al. 2022

BMC Endocr Disord

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Background Obesity is an important risk factor for hyperuricemia. We aimed to explore the relationship between perirenal fat thickness (PrFT) and paranephric fat thickness (PnFT) and serum uric acid (SUA) in patients with type 2 diabetes mellitus (T2DM). Methods This was a cross-sectional study involving 257 patients with T2DM recruited from Beijing Luhe Hospital from September 2019 to May 2020. The basic and clinical information such as age, gender, duration of diabetes was collected through the medical records. All patients underwent a physical examination including height, weight, waist circumference, hip circumference, systolic blood pressures and diastolic blood pressure. The venous blood and urine samples were collected to measure SUA, fasting blood glucose, total cholesterol, triglyceride, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, serum creatinine, blood urea nitrogen and glycosylated hemoglobin. PrFT and PnFT were measured via ultrasonography. Pearson correlation test and linear regression analysis were used to analyze the association between PrFT and PnFT and SUA. Results We found that PrFT and PnFT increased according to the tertiles of SUA level (P = 0.001 and P = 0.009, respectively). In addition, the PrFT and PnFT were positively associated with SUA level (r = 0.25, P < 0.001, r = 0.23, P < 0.001, respectively). Moreover, this association was stronger in males, non-obesity patients and patients with normal renal function. In the multivariate analysis, the PrFT was independently associated with SUA level after adjusting confounding factors. Conclusions The PrFT was independently associated with SUA level in patients with T2DM.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The perirenal fat thickness was independently associated with serum uric acid level in patients with type 2 diabetes mellitus

Yang

Cheng

et al. 2022

BMC Endocr Disord

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“…46,47 More recently, the perirenal fat thickness was recognized as a surrogate marker of metabolic syndrome in T2DM patients. 48 Irrespective of morphological changes in renal compartment volumes and RSF, elevated lipid deposition in renal parenchyma was observed in both clinical and preclinical studies at early stage DKD. These findings suggest that fat-sensitive MRI biomarkers such as Dixon quantified proton density fat fraction (PDFF) might be early indicators for the timely clinical intervention of DKD.…”

Section: Mri Markers Of Renal Morphologymentioning

confidence: 94%

Noninvasive Assessment of Diabetic Kidney Disease With MRI: Hype or Hope?

Zhao,

Seeliger,

Niendorf

et al. 2023

Magnetic Resonance Imaging

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Owing to the increasing prevalence of diabetic mellitus, diabetic kidney disease (DKD) is presently the leading cause of chronic kidney disease and end‐stage renal disease worldwide. Early identification and disease interception is of paramount clinical importance for DKD management. However, current diagnostic, disease monitoring and prognostic tools are not satisfactory, due to their low sensitivity, low specificity, or invasiveness. Magnetic resonance imaging (MRI) is noninvasive and offers a host of contrast mechanisms that are sensitive to pathophysiological changes and risk factors associated with DKD. MRI tissue characterization involves structural and functional information including renal morphology (kidney volume (TKV) and parenchyma thickness using T1‐ or T2‐weighted MRI), renal microstructure (diffusion weighted imaging, DWI), renal tissue oxygenation (blood oxygenation level dependent MRI, BOLD), renal hemodynamics (arterial spin labeling and phase contrast MRI), fibrosis (DWI) and abdominal or perirenal fat fraction (Dixon MRI). Recent (pre)clinical studies demonstrated the feasibility and potential value of DKD evaluation with MRI. Recognizing this opportunity, this review outlines key concepts and current trends in renal MRI technology for furthering our understanding of the mechanisms underlying DKD and for supplementing clinical decision‐making in DKD. Progress in preclinical MRI of DKD is surveyed, and challenges for clinical translation of renal MRI are discussed. Future directions of DKD assessment and renal tissue characterization with (multi)parametric MRI are explored. Opportunities for discovery and clinical break‐through are discussed including biological validation of the MRI findings, large‐scale population studies, standardization of DKD protocols, the synergistic connection with data science to advance comprehensive texture analysis, and the development of smart and automatic data analysis and data visualization tools to further the concepts of virtual biopsy and personalized DKD precision medicine. We hope that this review will convey this vision and inspire the reader to become pioneers in noninvasive assessment and management of DKD with MRI.Level of Evidence1Technical EfficacyStage 2

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“…Recent studies suggest that perirenal fat thickness (PrFT) measured by ultrasonography showed excellent consistency compared with MRI and can serve as a simple and reliable imaging indicator of visceral obesity in the metabolic syndrome; And perirenal fat was significantly associated with the levels of gamma-glutamyl transferase, fasting plasma glucose, waist circumference, and metabolic syndrome. 12 , 13 However, the relationship between PrFT and vitamin D status is unclear. Therefore, the aim of this study is to investigate the relationship between PrFT and serum 25-hydroxy vitamin D [25(OH)D] in MS patients.…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Serum Vitamin D and Perirenal Fat Thickness in Patients with Metabolic Syndrome in Community

Zhang¹,

Zhai²,

Gao³

et al. 2022

DMSO

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Background Visceral obesity is independently associated with hypovitaminosis D. Perirenal fat is a visceral fat type active in performing endocrine functions. However, the relationship between perirenal fat thickness (PrFT) and serum 25-hydroxy vitamin D [25(OH)D] is unclear. The aim of this study is to investigate the relationship between serum 25(OH)D and PrFT in patients with metabolic syndrome (MS) in the community. Methods From May to September 2020, 332 MS subjects in Qinfengyuan and Dongfang communities in Taiyuan City, China were enrolled in an MS survey. All the participants completed the questionnaire survey and physical examination, and their fasting blood samples were collected for biochemical examination. Abdominal ultrasonography was performed to measure the perirenal fat thickness. Results The mean serum 25(OH)D level for the 332 MS subjects was 13.5 ng/mL, the proportions of vitamin D deficiency [serum 25(OH)D < 20 ng/mL] and insufficiency [serum 25(OH)D = 20–29.9 ng/mL] were 60.8% (202) and 24.4% (81), respectively. Among the hypovitaminosis D [serum 25(OH)D < 30 ng/mL] subjects, the prevalence of abdominal obesity (waist circumference ≥ 90cm for men and ≥ 80cm for women) is 61.1%. Pearson correlation analysis showed that lg25(OH)D was significantly and negatively associated with body mass index (BMI), waist circumference (W), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), insulin resistance index (HOMA-IR), uric acid (UA)) and PrFT (all P<0.05), and positively correlated with high-density lipoprotein cholesterol (HDL-C) (P<0.05). Multivariate analysis showed that PrFT and HOMA-IR were independently correlated with 25(OH)D. Conclusion In screening MS patients, approximately 85% of the community MS patients in Taiyuan had hypovitaminosis D; in which 3/5 is abdominal obesity. PrFT is an independent risk factor for hypovitaminosis D in MS subjects.

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Perirenal Fat Thickness: A Surrogate Marker for Metabolic Syndrome in Chinese Newly Diagnosed Type 2 Diabetes

Cited by 9 publications

References 33 publications

The perirenal fat thickness was independently associated with serum uric acid level in patients with type 2 diabetes mellitus

The perirenal fat thickness was independently associated with serum uric acid level in patients with type 2 diabetes mellitus

Noninvasive Assessment of Diabetic Kidney Disease With MRI: Hype or Hope?

Relationship Between Serum Vitamin D and Perirenal Fat Thickness in Patients with Metabolic Syndrome in Community

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