The perirenal fat thickness was independently associated with serum uric acid level in patients with type 2 diabetes mellitus

Abstract

Background Obesity is an important risk factor for hyperuricemia. We aimed to explore the relationship between perirenal fat thickness (PrFT) and paranephric fat thickness (PnFT) and serum uric acid (SUA) in patients with type 2 diabetes mellitus (T2DM). Methods This was a cross-sectional study involving 257 patients with T2DM recruited from Beijing Luhe Hospital from September 2019 to May 2020. The basic and clinical information such as age, gender, duration of diabetes was collected through the medical records. All patients underwent a physical examination including height, weight, waist circumference, hip circumference, systolic blood pressures and diastolic blood pressure. The venous blood and urine samples were collected to measure SUA, fasting blood glucose, total cholesterol, triglyceride, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, serum creatinine, blood urea nitrogen and glycosylated hemoglobin. PrFT and PnFT were measured via ultrasonography. Pearson correlation test and linear regression analysis were used to analyze the association between PrFT and PnFT and SUA. Results We found that PrFT and PnFT increased according to the tertiles of SUA level (P = 0.001 and P = 0.009, respectively). In addition, the PrFT and PnFT were positively associated with SUA level (r = 0.25, P < 0.001, r = 0.23, P < 0.001, respectively). Moreover, this association was stronger in males, non-obesity patients and patients with normal renal function. In the multivariate analysis, the PrFT was independently associated with SUA level after adjusting confounding factors. Conclusions The PrFT was independently associated with SUA level in patients with T2DM.

Perirenal Fat Thickness is Associated with Metabolic Dysfunction-Associated Fatty Liver Disease in Type 2 Diabetes Mellitus

“… 19 Yang et al also revealed that PrFT was independently associated with serum UA levels in T2DM. 20 Meanwhile, PrFT was also reported as an independent predictor of hyperuricemia. 21 Ke et al found that PrFT was negatively correlated with the serum HDL-c level and positively correlated with cholesterol efflux capacity in T2DM.…”

The association between obesity indicators and metabolic risk factors in type-2 diabetic patients

“…Many studies suggested that accumulation of the visceral fat was associated with increased blood uric acid [ [31] , [32] , [33] ]. Matsuura F et al suggested that visceral fat was more strongly associated with hyperuricemia than subcutaneous fat in a study of male obese subjects as early as 1998 [ 34 ].…”

Thickened Perirenal Fat Predicts Poor Renal Outcome in Patients with Immunoglobulin A Nephropathy: A Population-Based Retrospective Cohort Study

“…Composed of both brown adipose tissue and white adipose tissue, PRF is able to synthesize and secrete many adipokines, such as leptin, adiponectin, and so on [ 5 ]. PRF plays an essential role in various diseases such as hypertension [ 6 ], unilateral nephrolithiasis [ 7 ], renal cell carcinoma [ 8 ], metabolic syndrome, and atherosclerosis [ 9 ]. In addition, its role in various renal diseases has been previously proposed [ 10 – 12 ].…”