Periprosthetic joint infection: what next?

Abstract

Periprosthetic joint infection (PJI) remains an extremely challenging complication. We have focused on this issue more over the last decade than previously, but there are still many unanswered questions. We now have a workable definition that everyone should align to, but we need to continue to focus on identifying the organisms involved. Surgical strategies are evolving and care is becoming more patient-centred. There are some good studies under way. There are, however, still numerous problems to resolve, and the challenge of PJI remains a major one for the orthopaedic community. This annotation provides some up-to-date thoughts about where we are, and the way forward. There is still scope for plenty of research in this area. Cite this article: Bone Joint J 2022;104-B(11):1193–1195.

WITHDRAWN: Vancomycin-cement reactions cause Red Man Syndrome and other life-threatening hypersensitivity reactions; the challenge of managing periprosthetic joint infection

“…With an 80-90% accuracy rate, two-stage revision is frequently considered the gold standard for treating PJI. First-stage antibiotic spacer establishment was already associated with various possible problems, such as fractures, displacements, and hypersensitivity reactions (2). We describe the deeper meaning of a medication reaction issue that arises after the implantation of an AIBC.…”

Role of Biomarkers in Periprosthetic Joint Infections

“…The serum and synovial markers described under separate headings in this review are not the gold standard for diagnosing PJI. Numerous and promising studies are ongoing to find a singular diagnostic tool capable of diagnosing PJI [ 81 ]. Among these, it is important to identify genetic polymorphisms that predispose patients to PJI.…”

Biofilm Homeostasis Interference Therapy via 1O2‐Sensitized Hyperthermia and Immune Microenvironment Re‐Rousing for Biofilm‐Associated Infections Elimination

“…[1][2][3] As one of the most frequent and severe complications after implant replacement surgery, BAIs can cause the failure of the surgery, requiring surgical revision. [1,4] Current evidence suggests that during the formation of BAIs, pathogens are aggregated and embedded into extracellular polymeric substances (EPS), developing complex communities to guarantee bacterial survival. [5,6] The natural self-productive EPS is composed of extracellular DNA (eDNA), polysaccharides, and proteins that block the diffusion and penetration of common clinical antibiotics.…”