Periprocedural anemia management in severe aortic stenosis patients undergoing transcatheter aortic valve implantation

Abstract

Preoperative anemia is a common finding in patients with severe aortic valve stenosis undergoing transcatheter aortic valve implantation (TAVI), and it has been shown to be associated with high mortality. The present review provides an overview of current management strategies of perioperative anemia in TAVI patients, including red blood cell transfusion, blood conservative protocol, iron supplementation, and erythropoietin administration. The goal is to recognize the treatable causes of anemia and treat them, in order to reduce transfusions and improve the outcome.

Intravenous iron supplement for iron deficiency in patients with severe aortic stenosis scheduled for transcatheter aortic valve implantation: results of the IIISAS randomised trial

“…In a subgroup of patients ( n = 56), intravenous iron resulted in improvements in both iron markers and symptoms at 30‐day follow‐up 2 . Consequently, many have emphasized the need for clinical trials to investigate the potential benefit of intravenous iron in patients with severe aortic stenosis 2,18–20 …”

“…2 Consequently, many have emphasized the need for clinical trials to investigate the potential benefit of intravenous iron in patients with severe aortic stenosis. 2,[18][19][20] The IIISAS trial included patients with iron deficiency, but only a few patients had anaemia, and severe anaemia was an exclusion criterion. Consequently, it cannot be concluded that intravenous iron does not have a position in the treatment of anaemic patients with severe aortic stenosis.…”

Clinical Effect of Microneedle Injection Combined with Blood Transfusion in the Treatment of Severe Anemia Complicated with Vitiligo under Regenerative Medical Technology

“…Clinical manifestations are often the pallor of skin and mucosa, tachypnoea, aggravation of fatigue, muscle weakness, etc. Moreover, there are even dyspnoea, nausea, abdominal pain, abdominal distension, chest tightness, and shortness of breath in a calm state [3]. If severe anemia occurs, patients need to go to the hospital for treatment in time.…”

Modified essential frailty toolset to determine outcomes following transcatheter aortic valve replacement

“…Conversely, in the longer-term, women have been considered to have better outcomes than men, which is in line with the results of the present study. This is because men tend to have vascular disease and comorbidities, including hypertension, diabetes mellitus, coronary artery disease, prior revascularization, and lower left ventricular ejection fractions, as seen in a previous study [22,23]. Furthermore, the presence of significant tricuspid regurgitation has been previously discussed as a predictor of mortality in TAVR patients.…”