Modified essential frailty toolset to determine outcomes following transcatheter aortic valve replacement

Higuchi, Ryosuke; Saitoh, Masakazu; Hagiya, Kenichi; Izumi, Yuki; Takamisawa, Itaru; Iguchi, Nobuo; Nanasato, Mamoru; Shimizu, Jun; Tobaru, Tetsuya; Shimokawa, Tomoki; Takanashi, Shuichiro; Takayama, Morimasa; Isobe, Mitsuaki

doi:10.1016/j.jjcc.2020.07.021

Cited by 9 publications

(5 citation statements)

References 25 publications

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“…Obviously, reduced exercise capacity has been known as a strong predicter for mortality or HF hospitalization, 22 – 24 and several papers reported that the frailty in patients who underwent TAVR independently predicted poor outcomes. 25 – 27 Exercise capacity has been associated with multiple factors, such as SV, HR, peripheral vascular resistance, autonomic balance, and skeletal muscles. 28 Regarding the autonomic nerve system, a previous study indicated that cardiac sympathetic nerve dysfunction assessed using MIBG imaging was associated with major adverse cardiovascular events after TAVR.…”

Section: Discussionmentioning

confidence: 99%

“…Obviously, reduced exercise capacity has been known as a strong predicter for mortality or HF hospitalization, 22-24 and several papers reported that the frailty in patients who underwent TAVR independently predicted poor outcomes. [25][26][27] Exercise capacity has been associated with multiple factors, such as SV, HR, peripheral vascular TAVR, which is thought to be important for the development of HF and improvement of prognosis. Last, the syncope status of patients was determined by reviewing medical records alone.…”

Section: Study Limitationsmentioning

confidence: 99%

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Clinical Impact of Preoperative Symptoms of Aortic Stenosis on Prognosis After Transcatheter Aortic Valve Replacement

Kemi,

Yamashita,

Kario

et al. 2024

Circ Rep

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Study Population and Data CollectionWe retrospectively enrolled 369 consecutive patients with native severe aortic valve stenosis who underwent TAVR at Gunma Prefectural Cardiovascular Center from 2014 to 2021. Clinical data, including age, sex, body surface area, blood pressure (BP), heart rate (HR), past history, medication, laboratory data, and echocardiography parameters were retrieved from electronic medical records. In addition, we checked the patients' preoperative symptoms and divided them into 4 groups by the main symptom: asymptomatic, chest pain (Canadian Cardiovascular Society class ≥I), HF (New York Heart Association [NYHA] functional class ≥II), and syncope (or presyncope; Figure 1). When symptoms overlapped, the primary physicians who reviewed the medical records made a judgment on which was dominant. The reasons why asymptomatic patients

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Section: Discussionmentioning

confidence: 99%

Section: Study Limitationsmentioning

confidence: 99%

Clinical Impact of Preoperative Symptoms of Aortic Stenosis on Prognosis After Transcatheter Aortic Valve Replacement

Kemi,

Yamashita,

Kario

et al. 2024

Circ Rep

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“…Frailty was measured using the Essential Frailty Toolset (EFT) which is a 4-item screening tool incorporating a chair rise activity which is self-reported, any cognitive decline which is reporter assessed, haemoglobin level, and serum albumin level. A score of 3 points indicates frailty [ 18 , 19 ], while a higher score of > 4 was associated with a reduced 2 years survival [ 19 ], and others associated higher all-cause mortality at 1, 2, and 3 years with higher modified EFT scores [ 20 ].…”

Section: Methodsmentioning

confidence: 99%

Quality of life and frailty outcomes following surgical and transcatheter aortic valve replacement

Surman

Abrahams

Kim

et al. 2022

J Cardiothorac Surg

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Background Our objective was to report on the prospective outcomes in the areas of depression, quality of life, angina, and frailty in SAVR and TAVR patients with aortic stenosis undergoing aortic valve intervention. Methods We recruited 300 patients across 3 groups (TAVR, SAVR, and CABG) over 12 months. Depression, quality of life, frailty, and angina were assessed followed by propensity score matching. Results Using logistical regression when all patient factors considered for all patients who had SAVR and TAVR, the only preoperative factors that impacted on 1 year mortality was hypertension and STS score. Quality of life improvements within each group over 12 months was significant (p value = 0.0001). Depression at 12 months between groups (p value = 0.0395) and within each group was significant (p value = 0.0073 for SAVR and 0.0001 for TAVR). Angina was most frequent in TAVR at 12 months in the QL (p = 0.0001), PL (p = 0.0007), and improvement was significant in the QL (SAVR p = 0.0010, TAVR p = 0.0001) and PL (SAVR p = 0.0002), TAVR p = 0.0007) domains in both groups. Frailty at 12 months improved in both groups, but was greatest in TAVR (p value = 0.00126). Conclusions This 12 months follow up of cardiac surgical patients has revealed significant improvement in PROMs and frailty in all groups by 3 months postoperative regardless of surgical or transcatheter approach. Outcome measures of quality of life and frailty could be utilized as a measure of outcome more regularly in patients undergoing aortic valve surgery regardless of approach.

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“…A lower EFT score correlates with increased postoperative complications and mortality, especially in TAVR patients. Studies have found an unadjusted Odds Ratio (OR) of 3.29 (95% CI 1.73-6.26) for predicting 30-day mortality, an OR of 3.72 (95% CI: 2.54-5.45) for predicting 1-year mortality, and an OR of up to 3.29 (95% CI 1.73-6.26) for predicting worsening disability post-TAVR [1][2][3][4].…”

Section: Essential Frailty Toolset (Eft)mentioning

confidence: 99%

Frailty Evaluation Impact on TAVR Outcomes: A Mini-Review

Arcens

2024

AJBSR

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Modified essential frailty toolset to determine outcomes following transcatheter aortic valve replacement

Cited by 9 publications

References 25 publications

Clinical Impact of Preoperative Symptoms of Aortic Stenosis on Prognosis After Transcatheter Aortic Valve Replacement

Clinical Impact of Preoperative Symptoms of Aortic Stenosis on Prognosis After Transcatheter Aortic Valve Replacement

Quality of life and frailty outcomes following surgical and transcatheter aortic valve replacement

Frailty Evaluation Impact on TAVR Outcomes: A Mini-Review

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