Periphere arterielle Verschlusskrankheit: Prädiktoren und Behandlungsintensität

Sander, Klaus; Bickel, Horst; C, Schulze Horn; Huntgeburth, Ulrich; Poppert, Holger; Sander, Dirk

doi:10.1055/s-2008-1046731

Cited by 7 publications

(2 citation statements)

References 15 publications

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“…This high prevalence of asymptomatic PAD in our population is comparable to the prevalence reported in other Arab and non-Arab populations, such as the cohorts in Germany, Switzerland, France, Japan, and Turkey. [ 21 – 24 ] Likewise, in the Arabian Gulf, Kownator et al reported a prevalence of asymptomatic PAD of 13.7% in patients with a single previous coronary or cerebrovascular event, with the highest reported in Kuwait (16.3%) and the United Arab Emirates (14.7%), and the lowest in Qatar (5.3%). [ 23 ] In the present study, we found that old age, hypertension, diabetes mellitus, hyperlipidemia, current smoking, previous CABG, and history of stroke were the main predictors of PAD in patients with CAD.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of previously unrecognized peripheral arterial disease in patients undergoing coronary angiography

Saleh¹,

Makhamreh²,

Qoussoos³

et al. 2018

Medicine

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Coronary artery disease (CAD) and peripheral arterial disease (PAD) are serious manifestations of systemic atherosclerosis. A considerable proportion of patients with CAD have associated PAD; however, many are asymptomatic and this condition remains underdiagnosed. Little is known about the prevalence and clinical implication of PAD in patients undergoing coronary angiography in the Middle East with no history of the disease.To study the prevalence of previously unrecognized PAD of the lower limbs in patients undergoing coronary angiography, and to determine the correlation with CAD.This is a prospective study conducted at a university tertiary referral hospital. A total of 2120 patients referred for coronary angiography without a prior diagnosis of PAD, between January 1, 2014 and December 31, 2014, were included. Patients were evaluated through detailed medical history taking, a questionnaire survey to assess symptoms and functional status, ankle-brachial index (ABI) measurement, and coronary angiography. PAD was considered present if the ABI was <0.90 in either leg.In all patients, the prevalence of previously unrecognized PAD was 12.8%. There was no significant difference between men and women (13.4% vs 11.7%, P = .485). Abnormal angiographic results were seen in 82% (1739 of 2120). The prevalence of PAD was 14.7% in patients with abnormal coronary angiographic result, significantly higher than that in patients with normal results (4.5%, P < .0001). The prevalence of abnormal angiographic results among patients with and without PAD was 96% and 80%, respectively (P = .001). Factors independently related to PAD were age (odds ratio [OR] 1.081, 95% confidence interval [CI] 1.053–1.109; P < .001), hypertension (OR 3.122, 95% CI: 1.474–5.678; P < .004), diabetes (OR 1.827, 95% CI: 0.975–2.171; P = .04), smoking (OR 1.301, 95% CI: 0.725–2.076; P < .001), previous coronary artery bypass grafting (OR 2.939, 95% CI: 1.385–5.219; P = .004), previous cerebrovascular accident (OR 3.212, 95% CI: 1.872–9.658; P = .003), left main CAD (OR 9.535, 95% CI: 3.978–20.230; P = .002), and multivessel CAD (OR 1.869, 95% CI: 1.018–2.798; P = .03). Patients with CAD and PAD were associated with a higher prevalence of multivessel CAD (58.2% vs 42.6%, P < .005) and left main disease (3% vs 0.3%, P < .0001).The prevalence of undiagnosed PAD in patients undergoing coronary angiography was 12.8% (14.7% in patients with CAD) and associated with a higher incidence of cardiovascular risk factors, multivessel disease, and left main disease. The high prevalence of PAD in patients with CAD confirms the importance of active screening for PAD by using ABI. Routine determination of ABI in the clinical evaluation of all patients with CAD may help identify high-risk patients.

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Section: Discussionmentioning

confidence: 99%

Prevalence of previously unrecognized peripheral arterial disease in patients undergoing coronary angiography

Saleh¹,

Makhamreh²,

Qoussoos³

et al. 2018

Medicine

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“…The present review did not identify any other pharmacologic trials in screen-detected PAD populations reporting patient health outcomes. Observational studies suggest both functional and mortality benefits of statins . An RCT of statin therapy in individuals with an abnormal ABI may be of uncertain value because many of these individuals may qualify for statin therapy based on 10-year risk alone—data from a 2008 large, individual participant data meta-analysis suggest that 95% of men and 41% of women with an ABI of 0.9 or less would already be above a 10% Framingham Risk Score 10-year risk threshold …”

Section: Discussionmentioning

confidence: 99%

Screening for Peripheral Artery Disease Using the Ankle-Brachial Index

Guirguis-Blake

Evans

Redmond

et al. 2018

JAMA

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IMPORTANCE Peripheral artery disease (PAD) is associated with a high risk for cardiovascular events and poor ambulatory function, even in the absence of symptoms. Screening for PAD with the ankle-brachial index (ABI) may identify patients in need of treatment to improve health outcomes. OBJECTIVE To systematically review evidence for the US Preventive Services Task Force on PAD screening with the ABI, the diagnostic accuracy of the test, and the benefits and harms of treatment of screen-detected PAD.

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Age-Related Changes in PLMS Characteristics of RLS Patients

Sharon

2013

Encyclopedia of Sleep

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Periphere arterielle Verschlusskrankheit: Prädiktoren und Behandlungsintensität

Abstract: The INVADE project confirms the high prevalence of PAD in an elderly population. These data underline the importance of measuring hsCRP for diagnosing and following PAD development.

Cited by 7 publications

References 15 publications

Prevalence of previously unrecognized peripheral arterial disease in patients undergoing coronary angiography

Prevalence of previously unrecognized peripheral arterial disease in patients undergoing coronary angiography

Screening for Peripheral Artery Disease Using the Ankle-Brachial Index

Age-Related Changes in PLMS Characteristics of RLS Patients

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