A literature review was conducted to evaluate the potential economic and clinical impact of hydrogel catheter materials on the incidence of catheter-related complications. Of 10,635 abstracts initially screened, 75 studies were included with 36 in outcomes, 28 for catheter materials, and 13 for economic analysis. The economic evaluation of peripherally inserted central catheters revealed a cost of $24,558 dollars for catheter-related thrombosis, $12,982 for infection, and $624 for occlusion which equate to a total national complication cost of $4.5 billion dollars annually. There was a 50% reduction in projected savings for all complications with the application of a hydrogel catheters which equated to nearly $1.8 million dollars annually for a typical 1000-bed acute care or $560,000 for a 300-bed facility. Limited clinical research on the hydrophilic catheter material suggests a remarkable and costeffective reduction for incidence of common catheter complications. More research is needed to confirm data from existing studies.