Peripherally Evoked Cortical Reflex in the Cuneate Nucleus

Towe, A.L.; Zimmerman, Irwin D.

doi:10.1038/1941250a0

Cited by 24 publications

(11 citation statements)

References 6 publications

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“…The latter component may be eliminated by freezing the cortex, a procedure which does not alter either the first component of the POn response or the activity evoked by the same peripheral stimulus in the VB. A similar cortical mechanism has been found by Towe & Zimmerman (1962) and by Gordon & Jukes (1964b) and used to explain the late negative wave recorded from the surface of the cuneate nucleus and the trans-synaptic activity of the gracile cells following stimulation of the main body of the medial lemniscus.…”

Section: Activity In the Ponsupporting

confidence: 65%

The activity of the posterior group of thalamic nuclei in the cat.

Calma¹

1965

The Journal of Physiology

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Section: Activity In the Ponsupporting

confidence: 65%

The activity of the posterior group of thalamic nuclei in the cat.

Calma¹

1965

The Journal of Physiology

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“…1977; Dykes & Craig, 1998). Because in the absence of an active cortex the ascending volleys cannot affect the CN by a transcortical route (Towe & Zimmerman, 1962), such afferent modulation and/or recurrent interactions (Amassian & De Vito, 1957; Andersen et al . 1964b; Gordon & Jukes, 1964; Canedo, 1997) should be more easily detected under this experimental condition.…”

Section: Resultsmentioning

confidence: 99%

“…1999) and prethalamic (Magni et al . 1959; Jabbur & Towe, 1961; Towe & Jabbur, 1961; Towe & Zimmerman, 1962; Andersen et al . 1964a; Gordon & Jukes, 1964; Levitt et al .…”

Section: Introductionmentioning

confidence: 99%

Spatial and cortical influences exerted on cuneothalamic and thalamocortical neurons of the cat

Canedo

Aguilar

2000

Eur J of Neuroscience

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This work aimed to study the responses of cuneothalamic and thalamocortical cells to electrical stimulation of the body surface in alpha-chloralose-anaesthetized cats. It was found that both classes of cells had a central excitatory receptive field, an edge overlapping the field centre whose stimulation elicited inhibitory-excitatory (cuneothalamic cells) and excitatory-inhibitory (thalamocortical cells) sequences, and a surrounding or peripheral area usually being inhibitory. Manipulating the descending corticofugal activity by removing the fronto-parietal cortex, electrical stimulation, or by placing picrotoxin or muscimol over the sensorimotor cortex demonstrated that the cortical feedback potentiated effects driven from the field centre and the surround. In particular this potentiated centre-driven excitation and surround-driven inhibition, but some of the data points to more complex patterns. The inhibition elicited in cuneothalamic cells from the edge and the surround of the field was faster than the excitation induced from the field centre. Effects at the edge of the field centre included late excitatory responses relayed via the cerebral cortex. There were also direct corticofugal excitatory inputs to the field centre. Excitatory surrounds were occasionally observed, the assumption being that in most cases these were suppressed by the enhanced inhibition driven from the cortex. The data indicate that the cortico-subcortical feedback contributes not only to enhance the surround antagonism of a centre response but also to increase the time resolution of thalamic and cuneate relay somesthetic neurons.

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“…The minimal latency for cortical excitation, for these cells, was shorter, by 1-11 msec, than the minimal latency for trans-synaptic excitation from the mid-brain: this evidence is compatible with the view that the effects of mid-brain stimulation depended on orthodromic excitation of lemniscal fibres and subsequent activation by thalamocortical fibres of the excitatory corticofugal path ending in the gracile nucleus. Such a route may have been concerned in the 'reflex' effects on the cuneate nucleus described by Towe & Zimmerman (1962): these effects were elicited by a peripherally evoked volley and depended on the intactness of the cerebral hemispheres. Such an explanation of the effects we have seen must, however, be extremely tentative.…”

Section: Trans-synaptic Excitationmentioning

confidence: 99%