Descending influences on the exteroceptive organizations of the cat's gracile nucleus

Gordon, G.; Jukes, M. G. M.

doi:10.1113/jphysiol.1964.sp007457

Cited by 126 publications

(41 citation statements)

References 22 publications

(20 reference statements)

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“…2B), they might be responsible for the initial powerful excitatory effects exerted by the cerebral cortex on CLs, as reported previously. 19,20 Concurrent activation of inhibitory interneurons would subsequently inhibit the CLs, which could intrinsically generate further rebound excitations brought about by hyperpolarization-activated 7,31 and low-threshold calcium conductances.…”

Section: Spread Of Cortical Paroxysmsmentioning

confidence: 99%

Sensorimotor cortical influences on cuneate nucleus rhythmic activity in the anesthetized cat

1999

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Section: Spread Of Cortical Paroxysmsmentioning

confidence: 99%

Sensorimotor cortical influences on cuneate nucleus rhythmic activity in the anesthetized cat

1999

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“…Therefore, synaptic inhibition regardless of the pathway involved, appears to be mediated through the same group of receptors all equally accessible to bicuculline and picrotoxin released from the micropipette. The hypothesis that a common pool of inhibitory pathways is the destination of the inhibitory pathways entering the cuneate (Gordon & Jukes, 1964b;Andersen et al, 1964a) demands that inhibition of cuneate relay cells is mediated by a single transmitter and that the receptors should behave as if they all belonged to the same population and lie equidistant from the tip of the micropipettes.…”

Section: Discussionmentioning

confidence: 99%

“…1964;Ros6n, 1969), were exquisitely sensitive to inhibition initiated by cutaneous stimulation of the ipsilateral limb (Gordon & Paine, 1960;Pearl, Whitlock & Gentry, 1962 ;Dawson et al, 1963;McComas, 1963) ; and the second excited by cortical stimulus (Levitt et al, 1964; never showed inhibition during peripheral stimulation (Gordon & Jukes, 1964a;Andersen, Eccles, Oshima & Schmidt, 1964). The cells characterized by cortical and afferent inhibition are also the recipients of inhibition originating in the contralateral limbs (Jabbur & Banna, 1968 and recurrently following antidromic invasions of their axons (Gordon & Paine, 1960;Gordon & Seed, 1961;Gordon & Jukes, 1964b; Andersen et al, 1964a). Independently Gordon & Jukes (1964b) and Andersen et al (1964a) concluded that all of the inhibitory pathways share the same cortically excited cells which therefore belong to a common pool of inhibitory interneurones.…”

Section: Introductionmentioning

confidence: 99%

“…The cells characterized by cortical and afferent inhibition are also the recipients of inhibition originating in the contralateral limbs (Jabbur & Banna, 1968 and recurrently following antidromic invasions of their axons (Gordon & Paine, 1960;Gordon & Seed, 1961;Gordon & Jukes, 1964b; Andersen et al, 1964a). Independently Gordon & Jukes (1964b) and Andersen et al (1964a) concluded that all of the inhibitory pathways share the same cortically excited cells which therefore belong to a common pool of inhibitory interneurones. The hypothesis received pharmacological support from the work of Banna & Jabbur (1969).…”

Section: Introductionmentioning

confidence: 99%

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On the pharmacology of ascending, descending and recurrent postsynatic inhibition of the cuneo‐thalamic relay cells in the cat

Kelly

Renaud

1973

British J Pharmacology

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Summary1. In cats decerebrated or anaesthetized with pentobarbitone, cells of the middle third of the cuneate nucleus that were excited by tactile stimulation of the ipsilateral forelimb (responding to displacement of hairs, skin or joints) and inhibited by electrical stimulation of the contralateral pyramid, were invariably inhibited by electrical stimulation of the ipsilateral forepaw and the contralateral forelimb nerves. 2. In 50% of the cats, the cells were more fully identified by placing electrodes stereotaxically in the contralateral medial lemniscus. Recurrent inhibition was always a concomitant of the antidromic action potential. 3. The intensity and the duration of inhibition evoked by all of these pathways was totally resistant to iontophoretic and intravenous strychnine in doses at least 5 times that required to block completely the response of the same cells to iontophoretic glycine and was extremely sensitive to either iontophoretic bicuculline or picrotoxin. 4. Although the inhibition was invariably sensitive to intravenous picrotoxin, no significant change occurred in the duration or intensity of the inhibition when bicuculline was administered intravenously (5 or 6 times) as repeated doses of 0-2 mg/kg. 5. Postsynaptic inhibition in the cuneate may be mediated by y-aminobutyric acid released from the nerve terminals of a common pool of interneurones shared by ascending, descending and recurrent pathways. Since the receptors involved in this pathway are resistant to intravenous bicuculline, they may well be distinct from those responsible for changes in the primary afferent terminal excitability, usually believed to be associated with presynaptic inhibition.

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“…The physio-A. J. McCOMAS AND P. WILSON logical significance of this descending projection has recently been the subject of intensive enquiry; the experiments have involved electrical stimulation of the cortex or of the descending fibre tracts and have been reviewed in several recent papers (Gordon & Jukes, 1964;Levitt, Carreras, Liu & Chambers, 1964;Andersen, Eccles, Schmidt & Yokota, 1964a, b;Andersen, Eccles & Sears, 1964). It is sufficient for the purposes of the present study to state that the descending axons have been shown to excite interneurones producing either presynaptic depolarization of cutaneous afferent fibres or post-synaptic inhibition of the somatosensory relay cells (Andersen, Eccles, Oshima & Schmidt, 1964).…”

Section: Introductionmentioning

confidence: 99%

An investigation of pyramidal tract cells in the somatosensory cortex of the rat

McComas¹,

Wilson²

1968

The Journal of Physiology

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SUMMARY1. An electrophysiological study has been made of pyramidal tract (PT) cells in the somatosensory cortex of the rat; the axons of the cells were shown to project either to the dorsal column nuclei or to the corticospinal tract.2. The corticospinal axons had conduction velocities of 7-6-108 m/sec. and therefore must have belonged to the large population of PT axons with relatively small diameters.3. PT cells constituted almost a quarter of the units encountered; they were distributed throughout the forepaw area within the deeper layers of the cortex.4. The sizes of the receptive fields of PT cells varied widely and did not differ significantly from those of non-PT cells.5. The latencies of PT cell discharges following peripheral stimulation showed less variation than those of non-PT cells though the mean latencies were identical.6. Most PT cells could be driven from the periphery and exhibited spontaneous activity in addition; they therefore function to maintain a continuous control over the somatosensory input to the brain which can be increased whenever the skin is stimulated.

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Descending influences on the exteroceptive organizations of the cat's gracile nucleus

Cited by 126 publications

References 22 publications

Sensorimotor cortical influences on cuneate nucleus rhythmic activity in the anesthetized cat

Sensorimotor cortical influences on cuneate nucleus rhythmic activity in the anesthetized cat

On the pharmacology of ascending, descending and recurrent postsynatic inhibition of the cuneo‐thalamic relay cells in the cat

An investigation of pyramidal tract cells in the somatosensory cortex of the rat

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