Peripheral Retinal Lesions in Eyes with Age-Related Macular Degeneration Using Ultra-Widefield Imaging

Forshaw, Thomas Richard Johansen; Minör, Åsa Susanna; Subhi, Yousif; Sørensen, Torben Lykke

doi:10.1016/j.oret.2019.04.014

Cited by 26 publications

(21 citation statements)

References 47 publications

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“…According to the literature, peripheral drusen, reticular pigmentary change, and paving stone degeneration occurred significantly more frequently in patients with AMD than in those without it [17,18]. This supports the notion that the disease is pan-retinal and not limited exclusively to the macula.…”

Section: Discussionsupporting

confidence: 61%

Peripheral Retinal Degenerations and Idiopathic Epiretinal Membrane: Analysis with Ultra-Wide-Field Scanning Laser Ophthalmoscopy

Ulfik-Dembska

Teper

Dembski

et al. 2021

JCM

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Background: The present study examined the relationships among retinal structure, peripheral retinal abnormalities, and epiretinal membrane (ERM) and explored the utility of ultra-wide-field laser scanning ophthalmoscopy in idiopathic ERM assessment. Methods: The study sample comprised 276 eyes of 276 patients. Ultra-wide field fundus imaging was performed without mydriasis using Optos California. Each patient underwent a Goldmann three-mirror contact lens fundus examination. Results: Ultra-wide field laser scanning ophthalmoscopy revealed peripheral retinal degeneration in 84 (54.54%) eyes in the ERM and in 28 (22.95%) eyes in the control group. Goldmann three-mirror contact lens examination revealed peripheral retinal degeneration in 96 (62.33%) eyes in the ERM group and 42 (34.42%) eyes in the control group. Ultra-wide field ophthalmoscopy enabled the detection of nearly 87% of all peripheral retinal lesions in patients with ERM, but it cannot replace fundus examination with a Goldmann triple mirror or ophthalmoscopy with scleral indentation. Conclusions: In most patients, idiopathic ERM coexisted with changes in the peripheral retina. Some of these changes promote retinal detachment. Thus, surgeons should consider the risk of retinal tear during vitrectomy, which increases the scope of surgery and may adversely affect prognosis. Although ultra-wide field imaging is a valuable diagnostic method, it is not a substitute for Goldmann three-mirror contact lens fundus examination or ophthalmoscopy with scleral indentation.

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Section: Discussionsupporting

confidence: 61%

Peripheral Retinal Degenerations and Idiopathic Epiretinal Membrane: Analysis with Ultra-Wide-Field Scanning Laser Ophthalmoscopy

Ulfik-Dembska

Teper

Dembski

et al. 2021

JCM

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“…67,68 Although the clinical management of age-related macular degeneration (AMD) is focused on macular imaging including OCT and FA, UWF imaging has allowed for monitoring of concurrent peripheral findings in both non-neovascular and neovascular AMD. 69–71 These studies have suggested that peripheral changes were found to be highly prevalent in eyes with AMD, supporting the claim that the disease is panretinal and not macula only; however, the clinical significance of peripheral lesions in AMD remains incompletely understood.…”

Section: Clinical Utility Of Widefield Imagingmentioning

confidence: 88%

Ultra-widefield retinal imaging: an update on recent advances

2020

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The development of ultra-widefield retinal imaging has accelerated our understanding of common retinal diseases. As we continue to validate the diagnostic and prognostic significance of pathology in the retinal periphery, the ability to visualize and evaluate these features in an efficient and patient-friendly manner will become more important. Current interest in ultra-widefield imaging includes the development of potential biomarkers of disease progression and indicators of preclinical disease development. This article reviews the current ultra-widefield imaging systems and recent advances in their applications to clinical practice with a focus on diabetic retinopathy, retinal vein occlusion, uveitis, and pediatric retina.

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“…With the hope of providing an overview of peripheral lesions in UWF studies of the retina, a 2019 meta-analysis by Forshaw et al systematically reviewed all studies using ultra-widefield imagining in AMD eyes [31]. Of the twelve eligible clinic-based studies of 3261 or more eyes in total, peripheral lesions (RPE change, retinal atrophy, drusen) were found in 82.7% of AMD eyes, compared to about 33.3% of healthy eyes.…”

Section: Recent Studiesmentioning

confidence: 99%

Peripheral Manifestations in Age Related Macular Degeneration: A Review of Imaging and Findings

Pivovar

Oellers

2021

JCM

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Purpose: To review novel findings in research with ultra-widefield imaging for analysis of peripheral manifestations in macular degeneration (AMD). We introduce the evolving widefield imaging modalities while summarizing the analytical techniques used in data collection of peripheral retinal findings thus far. Our review provides a summary of advancements to date and a commentary on future direction for AMD research. Methods: This is a literature review of all significant publications focused on the relationship between AMD and the retinal periphery conducted within the last two decades. Results and Conclusion: Promising research has been undertaken to elucidate peripheral retinal manifestations in macular degeneration using novel methodology. Advancements in ultra-widefield imaging and fundus autofluorescence have allowed us to elucidate peripheral retinal pigmentary changes, drusen deposition, and much more. Novel grid overlay techniques have been introduced to aid in analyzing these changes for pattern recognition and grouping of findings. This review discusses these findings in detail, providing evidence for the pan-retinal manifestations of AMD. Inter-study discordance in analytical approach highlights a need for more systematic future study.

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Peripheral Retinal Lesions in Eyes with Age-Related Macular Degeneration Using Ultra-Widefield Imaging

Cited by 26 publications

References 47 publications

Peripheral Retinal Degenerations and Idiopathic Epiretinal Membrane: Analysis with Ultra-Wide-Field Scanning Laser Ophthalmoscopy

Peripheral Retinal Degenerations and Idiopathic Epiretinal Membrane: Analysis with Ultra-Wide-Field Scanning Laser Ophthalmoscopy

Ultra-widefield retinal imaging: an update on recent advances

Peripheral Manifestations in Age Related Macular Degeneration: A Review of Imaging and Findings

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