Peripheral Reticular Pigmentary Degeneration and Choroidal Vascular Insufficiency, Studied by Ultra Wide-Field Fluorescein Angiography

Bae, Ki Hwan; Cho, Kyuyeon; Kang, Se Woong; Kim, Sang Jin; Kim, Jong Min

doi:10.1371/journal.pone.0170526

Cited by 11 publications

(10 citation statements)

References 28 publications

(29 reference statements)

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“…It starts at the equator in the nasal (or superior-nasal) retina, with more advanced cases spreading anteriorly and posteriorly, as well as circumferentially. 32,33 Peripheral reticular degeneration is highly associated with advancing age, 32 as well as age-related macular degeneration. 31,32,34 In one report of 104 patients with peripheral reticular degeneration, only one was younger than 50 years, and 82% were older than 60 years.…”

Section: Discussionmentioning

confidence: 99%

CLINICAL CHARACTERIZATION OF STARGARDT DISEASE PATIENTS WITH THE p.N1868I ABCA4 MUTATION

Collison¹,

Lee

Fishman

et al. 2019

Retina

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Purpose: To investigate the Stargardt disease phenotype associated with an unusually common and “extremely hypomorphic” ABCA4 variant, p.N1868I. Methods: The charts of 27 patients with p.N1868I on one allele and a severe/deleterious mutation on the other allele were reviewed. Subjective age of onset, best-corrected visual acuity, and stage of disease were recorded for all 27 patients, 18 of whom had multiple visits. When available, fundus photography, spectral domain optical coherence tomography, fundus autofluorescence, full-field electroretinograms, Goldmann visual fields, and fluorescein angiography were included. Five families with multiple affected members were analyzed. Results: The median age at symptom onset was 41.5 years, and 3 p.N1868I patients had not developed visual symptoms as of the most recent eye examination. Median best-corrected visual acuity in the better-seeing eye at baseline was 20/25−2, and the median duration from symptom onset to legal blindness was 25 years. The five families described in this study demonstrated clinically significant intrafamilial variability, and affected family members who did not share the p.N1868I variant had relatively more severe phenotypes. Conclusion: This study demonstrates the consistency of foveal sparing, the variation in age at onset, the intrafamilial variability, and the prognosis with regard to visual acuity in p.N1868I-associated Stargardt disease.

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Section: Discussionmentioning

confidence: 99%

CLINICAL CHARACTERIZATION OF STARGARDT DISEASE PATIENTS WITH THE p.N1868I ABCA4 MUTATION

Collison¹,

Lee

Fishman

et al. 2019

Retina

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“…The lesions are more polygonal forming geometric patterns in the peripheral fundus and occur in association with age-related macular degeneration unlike the lesion seen in our case. [4]…”

Section: Discussionmentioning

confidence: 99%

Coastline like peripheral chorioretinal degeneration as a suspected cause of nasal retinal dialysis

Sundar

Sharma

Chawla

et al. 2019

Indian J Ophthalmol

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Retinal dialysis is mostly associated with blunt trauma or at times spontaneous. A patient presented to us with fresh rhegmatogenous retinal detachment with no telltale history or signs of trauma. The causative break was retinal dialysis noted on the superonasal periphery. A characteristic peripheral chorioretinal degeneration simulating a coastline almost extending six clock hours was seen in both the eyes. We have discussed this rare presentation and the possibilities of the association between this newly identified lesion and spontaneous retinal dialysis in the following case report.

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“…In their 2017 study, Bae et al took a different approach by studying ultra-widefield fluorescein angiography of the retinal periphery [25]. To analyze peripheral reticular pigmentary degeneration, the group divided the retina into four quadrants, using hour units to measure the extent of the lesions.…”

Section: Proposed Grid Systemsmentioning

confidence: 99%

Peripheral Manifestations in Age Related Macular Degeneration: A Review of Imaging and Findings

Pivovar

Oellers

2021

JCM

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Purpose: To review novel findings in research with ultra-widefield imaging for analysis of peripheral manifestations in macular degeneration (AMD). We introduce the evolving widefield imaging modalities while summarizing the analytical techniques used in data collection of peripheral retinal findings thus far. Our review provides a summary of advancements to date and a commentary on future direction for AMD research. Methods: This is a literature review of all significant publications focused on the relationship between AMD and the retinal periphery conducted within the last two decades. Results and Conclusion: Promising research has been undertaken to elucidate peripheral retinal manifestations in macular degeneration using novel methodology. Advancements in ultra-widefield imaging and fundus autofluorescence have allowed us to elucidate peripheral retinal pigmentary changes, drusen deposition, and much more. Novel grid overlay techniques have been introduced to aid in analyzing these changes for pattern recognition and grouping of findings. This review discusses these findings in detail, providing evidence for the pan-retinal manifestations of AMD. Inter-study discordance in analytical approach highlights a need for more systematic future study.

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Peripheral Reticular Pigmentary Degeneration and Choroidal Vascular Insufficiency, Studied by Ultra Wide-Field Fluorescein Angiography

Cited by 11 publications

References 28 publications

CLINICAL CHARACTERIZATION OF STARGARDT DISEASE PATIENTS WITH THE p.N1868I ABCA4 MUTATION

CLINICAL CHARACTERIZATION OF STARGARDT DISEASE PATIENTS WITH THE p.N1868I ABCA4 MUTATION

Coastline like peripheral chorioretinal degeneration as a suspected cause of nasal retinal dialysis

Peripheral Manifestations in Age Related Macular Degeneration: A Review of Imaging and Findings

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