Peripheral primitive neuroectodermal tumour of the cervix

Pauwels, Patrick; Ambros, Peter F.; Hattinger, Claudia Maria; Lammens, Martin; Cin, Paola Dal; Ribot, J. G.; Struyk, A. P. H. B.; Berghe, Herman Van den

doi:10.1007/pl00008201

Cited by 43 publications

(19 citation statements)

References 17 publications

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“…Although Ewing's sarcomas are more common in the bone there are examples of extra osseous tumours that may resemble PNET. There have been a number of case reports for peripheral PNETs including those in the eye [6,7], gynaecological organs [8,9,10] and intraabdominal sites [11,12], kidneys [13,14], skin and subcutaneous tissue [15]. Among all these sites intraabdominal site is very rare.…”

Section: Discussionmentioning

confidence: 99%

Peripheral Primitive Neuro-Ectodermal Tumor - A Case Report

Sen¹,

Basu²,

Bandyopadhyay³

et al. 2016

IOSR

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Section: Discussionmentioning

confidence: 99%

Peripheral Primitive Neuro-Ectodermal Tumor - A Case Report

Sen¹,

Basu²,

Bandyopadhyay³

et al. 2016

IOSR

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“…Depuis, 6 observations seulement ont été rapportés dans la littérature anglosaxonne [6][7][8][9]. La PNET est une tumeur de la femme d'âge moyen de 40 ans avec des extrêmes de 26 à 50 ans.…”

Section: Discussionunclassified

“…Le noyau est hyperchromatique (HES × 40). En cartouche, l'étude immunohistochimique par le CD99 montre un marquage membranaire des cellules tumorales dans 1 cas, un carcinome peu diffé-rencié dans un cas et un carcinome épidermoïde dans un autre cas [1,4,[6][7][8][9]. Ces diagnostics ont été redressés sur la pièce opératoire après étude morphologique et immunohistochimique.…”

Section: Discussionunclassified

Tumeur neuroectodermique primitive du col ut�rin: � propos d?un cas

et al. 2004

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Les auteurs rapportent l'observation d'une femme tunisienne âgée de 50 ans, nullipare et ménopausée depuis 10 ans, qui consultait pour des métrorragies. L'examen clinique révélait une masse bourgeonnante du col utérin de 2,5 cm de grand axe dont la biopsie avait montré une prolifé-ration tumorale maligne faite de petites cellules rondes. L'étude immunohistochimique a retenu le diagnostic de tumeur neuroectodermique primitive du col utérin (PNET). La patiente avait bénéficié d'une chimiothérapie néo-adjuvante suivie d'un traitement radical. L'évolution était marquée par une récidive locale de la tumeur après 18 mois, la patiente est décédée 6 mois après.La localisation cervicale des PNET est exceptionnelle mais a déjà été rapportée. Les difficultés diagnostiques sont développées. Primitive neuroectodermal tumor of the cervix: a case reportAbstract: We report a case of 50 year-old menopausal and nulliparous tunisian woman who presented with vaginal bleeding. Physical examination revealed a 2.5 cm exophytic mass. The specimen biopsy showed a small cell malignant tumour. The diagnosis of primitive neuroectodermal tumour of the cervix was retained after immunohitochemical staining.The patient underwent a radical resection with adjuvant chemotherapy. Local recurrence appeared 18 months later and the patient died 6 months later.Primitive neuroectodermal tumour of the cervix are uncommon. The diagnostic difficulties are reviewed.

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“…To the best of our knowledge, only 14 cases have been described between 1987 and 2015 in the English literature (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) and there are currently no universally accepted standard treatment guidelines. Data on long-term follow-up are not available and the clinical outcome of PNET patients remains elusive (4)(5)(6). The aim of this study was to present two cases of primary PNET of the cervix and describe the diagnostic and treatment procedures.…”

Section: Introductionmentioning

confidence: 99%

Primary primitive neuroectodermal tumor of the cervix: A report of two cases and review of the literature

Wang

Gao

et al. 2017

Molecular and Clinical Oncology

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Abstract. Peripheral primitive neuroectodermal tumor (PNET) of the cervix uteri is extremely rare. Two cases of PNET of the cervix are presented herein. Two female patients, aged 48 and 43 years, presented with irregular uterine bleeding over the course of 1 year, and increased urinary frequency for 1 month, respectively. On gynecological examination, a mass in the cervix was palpated and a biopsy performed. The findings of the initial biopsy revealed small-cell carcinoma in both patients. Following neoadjuvant chemotherapy and radiotherapy, radical hysterectomy was performed in both patients. One patient received 5 courses of consolidation chemotherapy and postoperative radiotherapy, whereas the other patient received 1 course of consolidation chemotherapy. At the time of the article submission, both patients remained disease-free at 27 and 12 months, respectively, after their initial diagnosis. Only a limited number of cases of PNET of the cervix uteri have been reported in the literature to date. Multimodal therapies, including total excision, adjuvant chemotherapy and/or radiotherapy, have been adopted to treat patients with PNET of the cervix. IntroductionThe term primitive neuroectodermal tumor (PNET) was first introduced by Hart and Earle to describe tumors composed of small round cells with different degrees of neural, glial and ependymal differentiation (1). PNETs have been classified according to the World Health Organization as central-and peripheral-type. Central PNETs usually involve the brain and spinal cord, whereas peripheral PNET involve the sympathetic nervous system, skeleton and soft tissues (2).PNETs of the cervix are extremely rare. To the best of our knowledge, only 14 cases have been described between 1987 and 2015 in the English literature (3-14) and there are currently no universally accepted standard treatment guidelines. Data on long-term follow-up are not available and the clinical outcome of PNET patients remains elusive (4-6). The aim of this study was to present two cases of primary PNET of the cervix and describe the diagnostic and treatment procedures. Case reportsCase 1. A 48-year-old woman, gravida 3, para 2, presented with irregular uterine bleeding over the course of 1 year. On gynecological examination, a cervical mass rich in blood vessels was identified, measuring 6.0 cm in its greatest dimension (Fig. 1). The left parametrium was also involved, and the tumor was staged as IIb. A cervical biopsy was performed and the initial diagnosis was small-cell carcinoma.Histologically, the tumor comprised small blue-stained tumor cells with scant cytoplasm, arranged in dense sheets, without rosette or gland formation. Areas of necrosis were present. The neoplastic cells, some of which exhibited prominent nucleoli, infiltrated several capillaries. The cells uniformly expressed CD99 and vimentin, whereas synaptophysin (Syn), CD56, S-100 and epithelial membrane antigen were focally positive. Neuron-specific enolase (NSE), chromogranin A (CgA), cytokeratin (CK), CK5, CK8/18, P16, leukoc...

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Peripheral primitive neuroectodermal tumour of the cervix

Cited by 43 publications

References 17 publications

Peripheral Primitive Neuro-Ectodermal Tumor - A Case Report

Peripheral Primitive Neuro-Ectodermal Tumor - A Case Report

Tumeur neuroectodermique primitive du col ut�rin: � propos d?un cas

Primary primitive neuroectodermal tumor of the cervix: A report of two cases and review of the literature

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