Peripheral plasma progesterone levels during human pregnancy and labor

Csapo, A.I.; Knobil, E.; Molen, H. J. van der; Wiest, Walter G.

doi:10.1016/0002-9378(71)90242-0

Cited by 112 publications

(39 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Plasma oestradiol 17,3 levels ( fig. 1) continued to rise in the normal control patients until the 37th week of gestation, when a plateau was reached (Rado et al, 1970;Csapo et al, 1971). Levels of oestradiol 17,3 in 26 samples of plasma taken from normal controls at about the 35th week of gestation averaged 20 ± 1 ng/ml.…”

Section: Resultsmentioning

confidence: 90%

Progesterone Deficiency and Premature Labour

Csapo¹,

Pohánka²,

Kaihola³

1974

BMJ

View full text Add to dashboard Cite

Journal, 1974, 1, 137-140 Summary Plasma oestradiol 17,B and progesterone levels in 11 patients admitted to hospital for threatened premature labour of unknown aetiology were compared with those of women at similar stages of gestation whose pregnancy was normal. Oestradiol levels in the study group were slightly higher than in the normal controls but their progesterone levels were significantly lower. This progesterone deficiency increased the oestradiol/progesterone ratio in the study group patients, and it increased still more as the progesterone withdrawal continued during premature labour.Since uterine activity during pregnancy is regulated by a balanced action of several factors a deficiency in progesterone, an opponent of uterine activity, creates a regulatory imbalance which, if uncorrected, provokes premature labour. An increase in uterine volume stimulates uterine activity, and the present study reinforced our previous conclusion that the uterine-volume/plasma-progesterone ratio is a more accurate measure of the state of regulatory balance than the progesterone level alone.The cause of the progesterone deficiency in these cases remains unexplained, but we suggest that placental growth and function are contributory factors. We are investigating ways of correcting the resulting imbalance in the regulatory mechanism.

show abstract

Section: Resultsmentioning

confidence: 90%

Progesterone Deficiency and Premature Labour

Csapo¹,

Pohánka²,

Kaihola³

1974

BMJ

View full text Add to dashboard Cite

show abstract

“…In many mammals processes occur at the end of pregnancy to reduce maternal or placental production of progesterone so that maternal circulating concentrations of progesterone fall dramatically precipitating labor; but this does not happen in human beings. 19,20 In human beings, maternal circulating concentrations of progesterone rise progressively across pregnancy and only decline with the delivery of the placenta. It seems that in human beings, estrogen action may increase to override the action of the progesterone brake.…”

mentioning

confidence: 99%

Why the heart is like an orchestra and the uterus is like a soccer crowd

Smith

Imtiaz

Banney

et al. 2015

American Journal of Obstetrics and Gynecology

View full text Add to dashboard Cite

“…Csapo (1969) proposed that labour ensued when the inhibitory effect of progester¬ one on the myometrium was withdrawn, permitting oestradiol to initiate contractions. Changes in the con¬ centrations of these hormones in peripheral plasma which support this hypothesis have been reported (Csapo, Knobil, van der Molen & Wiest, 1971; Turn¬ bull, Patten, Flint et al 1974), but this has not been the general experience (Llauro, Runnebaum & Zander, 1968;Yannone, McCurdy & Goldfien, 1968;Shaaban & Klopper, 1973;Boroditsky, Reyes, Winter & Faiman, 1978;Hartikainen-Sorri, Kauppila, Tuimala et al 1981;Anderson, Hancock & Oakey, 1985).…”

Section: Introductionmentioning

confidence: 81%

Oestriol and non-protein-bound oestriol concentrations in human peripheral plasma before labour and delivery

Moutsatsou¹,

Oakey²

1986

Journal of Endocrinology

View full text Add to dashboard Cite

The concentration of oestriol and the proportion of this hormone not bound to plasma protein were measured using radioimmunoassay and centrifugal ultrafiltration respectively, in 55 samples of plasma obtained from 12 women in the last 2 to 7 weeks of uncomplicated pregnancy. Among individuals, the mean plasma concentration of oestriol varied from 25.8 +/- 94.8 nmol/l; in nine subjects, there was a tendency for oestriol concentrations to increase as delivery approached. The mean proportion of oestriol not bound to plasma protein in the different subjects varied from 13.1 to 18.9%, but values from any individual subject remained essentially constant during the periods of study. These measured values were used to calculate, for each sample, the apparent concentration of oestriol not bound to plasma protein. The results were combined with analogous values for oestradiol and progesterone obtained from the same plasma samples and described in a previous study. It was found that the mean ratio of the concentration of oestriol and oestradiol was 0.75, the mean concentration of non-protein-bound oestriol was 8.7 times that of non-protein-bound oestradiol, and in individual subjects, there was no consistent trend as delivery approached in the ratio of the concentration of progesterone to that of oestriol in either the total or non-protein-bound form.

show abstract

Peripheral plasma progesterone levels during human pregnancy and labor

Cited by 112 publications

References 9 publications

Progesterone Deficiency and Premature Labour

Progesterone Deficiency and Premature Labour

Why the heart is like an orchestra and the uterus is like a soccer crowd

Oestriol and non-protein-bound oestriol concentrations in human peripheral plasma before labour and delivery

Contact Info

Product

Resources

About