Peripheral neurostimulation in headache treatment

Sokolov, Alexey Y.; Lyubashina, O. A.; Vaganova, Yu S; Амелин, А. В.

doi:10.17116/jnevro201911910179

Cited by 5 publications

(2 citation statements)

References 96 publications

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“…(2020), о положительном влиянии транскраниальной электротерапии на лечение мигрени с ЛИГБ в сочетании с курсом дезинтоксикационной терапии [19]. В области немедикаментозного лечения ХМ возможно применение различных нейромодулирующих методов [20].…”

Section: результаты и обсуждениеunclassified

Transcranial Electroanalgesia as an Auxiliary Treatment for Chronic Migraine with Medication Abuse

Чернуха,

Лихачев,

Глеб

et al. 2023

Неврология И Нейрохирургия. Восточная Европа

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Цель. Оценить результаты комплексного лечения хронической мигрени (ХМ) в сочетании с лекарственно-индуцированной головной болью (ЛИГБ) с использованием метода транскраниальной электроанальгезии (ТЭА). Материалы и методы. В основную группу вошел 61 пациент с ХМ в сочетании с ЛИГБ. 31 пациент получал стандартную терапию согласно клиническим протоколам и курс ТЭА. Контрольную группу составили 30 пациентов, получавших стандартную терапию. Все пациенты самостоятельно заполняли дневники головной боли в течение как минимум одного месяца, указывали интенсивность головной боли по визуальной аналоговой шкале (ВАШ). Также применялся Headache Impact Test (индекс HIT-6) с определением четырех степеней воздействия на повседневную активность и Лидский опросник зависимости (ЛОЗ) – Leeds Dependence Questionnaire (LDQ) до и после курса лечения. Для транскраниальной электротерапии использовался прибор «Радиус-01 Кранио» (Россия). Результаты. При оценке эффективности лечения в основной и контрольной группе методом множественного регрессионного анализа установлено достоверное снижение дней головной боли в месяц в исследуемой группе, снижение интенсивности по ВАШ и отсутствие влияния включения в комплексную терапию ТЭА на количество приступов головной боли (Multiple R=0,714, р=0,02). Таким образом, полученные данные позволяют сделать вывод о положительном влиянии ТЭА на ЛИГБ при ХМ. Заключение. Назначение методики электроанальгезии у пациентов с ХМ более предпочтительно при наличии ЛИГБ. ТЭА может быть рекомендована к более широкому применению у пациентов с ХМ, отягощенной ЛИГБ, в повседневной практике. Purpose. To evaluate the results of complex treatment of chronic migraine (CM) in combination with medication-overuse headache (MOH) using the method of transcranial electroanalgesia (TEA). Materials and methods. The study group included 61 patients with CM in combination with DIH. 31 patients received standard therapy, according to clinical protocols, and a course of TEA. The control group consisted of 30 patients who received standard therapy. All patients self-completed headache diaries for at least one month, indicating the intensity of headache on a visual analogue scale (VAS). The Headache Impact Test (HIT-6 index) with four levels of impact on daily activities and the Leeds Dependence Questionnaire (LDQ) were also assessed before and after treatment. The device "Radius-01 Cranio" (Russia) was used for transcranial electrotherapy. Results. The method of multiple regression analysis revealed a significant decrease in headache days per month in the study group, a decrease in intensity according to the VAS scale, and no effect of including TEA in complex therapy on the number of headache attacks (Multiple R=0.714, p=0.02). Thus, the data obtained allow us to conclude that TEA has a positive effect on DIH in CM. Conclusion. The appointment of electroanalgesia technique in patients with CM is more preferable in the presence of DIH. TEA may be recommended for wider use in patients with CM aggravated by MOH in daily practice.

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Section: результаты и обсуждениеunclassified

Transcranial Electroanalgesia as an Auxiliary Treatment for Chronic Migraine with Medication Abuse

Чернуха,

Лихачев,

Глеб

et al. 2023

Неврология И Нейрохирургия. Восточная Европа

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“…Migraine is widespread in the world population and is a global social problem, causing significant damage to the economies of different countries due to direct and indirect material losses [ 3 , 5 – 7 ]. Migraine treatment implies an alleviation and prevention of headache attack for which both medicinal and non-drug-induced approaches are used [ 8 – 10 ]. Unfortunately, the quality of this treatment leaves much to be desired and, despite the noticeable progress in the management of this cephalalgia and the expansion of the arsenal of specific drugs [ 11 , 12 ], there remains a high unmet need for effective and safe methods of anti-migraine therapy [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Advantages of imaging photoplethysmography for migraine modeling: new optical markers of trigemino‐vascular activation in rats

et al. 2021

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Background Existent animal models of migraine are not without drawbacks and limitations. The aim of our study was to evaluate imaging photoplethysmography (PPG) as a method of assessing intracranial blood flow in rats and its changes in response to electrical stimulation of dural trigeminal afferents. Methods Experiments were carried out with 32 anesthetized adult male Wistar rats. Trigeminovascular system (TVS) was activated by means of electrical stimulation of dural afferents through a closed cranial window (CCW). Parameters of meningeal blood flow were monitored using a PPG imaging system under green illumination with synchronous recording of an electrocardiogram (ECG) and systemic arterial blood pressure (ABP). Two indicators related to blood-flow parameters were assessed: intrinsic optical signals (OIS) and the amplitude of pulsatile component (APC) of the PPG waveform. Moreover, we carried out pharmacological validation of these indicators by determining their sensitivity to anti-migraine drugs: valproic acid and sumatriptan. For statistical analysis the non-parametric tests with post-hoc Bonferroni correction was used. Results Significant increase of both APC and OIS was observed due to CCW electrical stimulation. Compared to saline (n = 11), intravenous administration of both the sumatriptan (n = 11) and valproate (n = 10) by using a cumulative infusion regimen (three steps performed 30 min apart) lead to significant inhibitory effect on the APC response to the stimulation. In contrast, intravenous infusion of any substance or saline did not affect the OIS response to the stimulation. It was found that infusion of either sumatriptan or valproate did not affect the response of ABP or heart rate to the stimulation. Conclusions Imaging PPG can be used in an animal migraine model as a method for contactless assessment of intracranial blood flow. We have identified two new markers of TVS activation, one of which (APC) was pharmacologically confirmed to be associated with migraine. Monitoring of changes in APC caused by CCW electrical stimulation (controlling efficiency of stimulation by OIS) can be considered as a new way to assess the peripheral mechanism of action of anti-migraine interventions.

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Neurophysiological and Vascular Mechanisms of Action of Serotoninergic Drugs for Abortive Migraine Treatment

Sokolov,

Skiba,

Lyubashina

2024

Neurosci Behav Physi

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Peripheral neurostimulation in headache treatment

Cited by 5 publications

References 96 publications

Transcranial Electroanalgesia as an Auxiliary Treatment for Chronic Migraine with Medication Abuse

Transcranial Electroanalgesia as an Auxiliary Treatment for Chronic Migraine with Medication Abuse

Advantages of imaging photoplethysmography for migraine modeling: new optical markers of trigemino‐vascular activation in rats

Neurophysiological and Vascular Mechanisms of Action of Serotoninergic Drugs for Abortive Migraine Treatment

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