Peripheral neuropathy associated with prolonged use of linezolid

Bacteremia with an Iliopsoas Abscess and Osteomyelitis of the Femoral Head Caused by <i>Enterococcus avium</i> in a Patient with End-stage Kidney Disease

“…If treatment for ampicillin-resistant enterococcal infection is unsuccessful, the addition of an aminoglycoside or other type of anti-MRSA drug, such as linezolid or daptomycin, should be considered. Moreover, a long duration of therapy is expected, as linezolid is often difficult to administer due to concerns regarding bone marrow suppression and/or severe peripheral and optic neuropathy (33). In the present case, daptomycin was not available at the time of treatment.…”

Linezolid induced optic neuropathy, a serious yet reversible adverse effect: a case report

“…Optic neuropathy has been reported previously as an adverse effect in patients using linezolid [2][3][4][5][6][7].…”

Visual side effects after prolonged MRSA treatment

“…In most cases, the optic Correspondence neuropathy resolved with drug cessation, leaving a residual deficit in central visual acuity. [3][4][5][6][7][8] The mechanism of toxicity remains unclear although previous reports of linezolid associated optic neuropathies suggest mitochondrial dysfunction as the most possible cause of neurotoxicity. In particular, low folate levels subsequently cause elevated plasma homocysteine, which can lead to inhibition of neuronal mitochondrial function.…”

“…Intravitreal triamcinolone alone has been reported to reduce macula oedema and the amount of hard exudates. 4,5 Takagi et al, 6 Sakuraba et al, 7 and Takaya et al 8 have removed macular hard exudates surgically following vitrectomy. Despite good anatomical results, visual acuity improvement was not maintained long term with surgical removal alone because of atrophic or degenerative changes.…”