Linezolid induced optic neuropathy, a serious yet reversible adverse effect: a case report

Shah, Rushikesh; Lamichhane, Samir

doi:10.24911/ejmcr/1/28

Cited by 2 publications

(3 citation statements)

References 11 publications

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“…It is relatively safe when used for a period of fewer than 28 days (16). In the majority of reported cases of neuropathy, the dose was 600 mg once daily, and the length of exposure ranged from 5 to 14 months (8)(9)(10)(11). After conducting a systematic review and meta-analysis of the efficacy and safety of therapy with linezolid-containing regimens in the treatment of drug-resistant tuberculosis, Zhang X et al determined that neurotoxicity with peripheral neuropathy occurs in 30% of patients who had received doses <or equal to 600 mg/day for 4-6 months (7,16).…”

Section: Discussionmentioning

confidence: 99%

“…Linezolid-induced optic neuropathy is nearly reversible, but the exact duration of symptom resolution following drug discontinuation is unknown. The majority of reported cases of optic neuropathy resolved within 1-3 months of drug discontinuation (8)(9)(10)(11). However, the presence of other systemic illnesses can impede optic neuropathy recovery.…”

Section: Discussionmentioning

confidence: 99%

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A Case Report and Literature Review of the Outcome of Linezolid-Induced Optic and Peripheral Neuropathy in Patients With Multidrug-Resistant Pulmonary TB

et al. 2022

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Linezolid is a second-line medication used to treat tuberculosis that has become resistant to multiple drugs. Linezolid has been shown to be effective in treating drug-resistant TB. However, long-term therapy is hampered by the related side effects, such as ocular and peripheral neuropathy. We recently encountered a 32-year-old male undergoing linezolid therapy for 12 months for multidrug-resistant tuberculosis who presented with progressive painless visual impairment and peripheral neuropathy symptoms in lower limbs as well as ataxic gait. Nerve conduction study findings of length-dependent axonal sensory polyneuropathy with bilateral optic neuropathy evident on fundoscopy suggested a case of toxic neuropathy. Following the termination of linezolid, follow-up visits revealed an improvement in visual symptoms. While there has been no discernible improvement or deterioration of peripheral neuropathy. In a developing country like Pakistan, where the rising number of cases of multidrug-resistant tuberculosis and its management is a major problem, physicians should be made aware of linezolid induced neuropathy so that close follow-up sessions for patients on long-term linezolid therapy can be arranged to avoid serious neurological consequences.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Case Report and Literature Review of the Outcome of Linezolid-Induced Optic and Peripheral Neuropathy in Patients With Multidrug-Resistant Pulmonary TB

et al. 2022

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“…Data from [5,9–11,15–23,32,34,39 ▪ ,40 ▪ ,41–57,58 ▪ ,59–66]. MRSA, methicillin-resistant staphylococcus aureus; TB, tuberculosis.…”

Section: Characteristics Of Linezolid-associated Optic Neuropathymentioning

confidence: 99%

Linezolid optic neuropathy

Miller,

Cao,

McClelland

et al. 2023

Current Opinion in Ophthalmology

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Purpose of review In this article, we reviewed 67 reported cases of linezolid optic neuropathy and describe the common characteristics and expectations for recovery with an emphasis on recent findings in the literature. Recent findings Linezolid classically causes a reversible, duration-dependent optic neuropathy. However, in our review, we found only 66.7% of patients recovered complete visual function. Vision loss most commonly affected visual acuity followed by visual field and color vision. We also found patients taking higher doses of linezolid experienced full recovery less often, suggesting a dose-dependent component of linezolid optic neuropathy. Linezolid use has increased in frequency and duration, especially in the treatment of drug-resistant tuberculosis, and data indicate that these patients experience lower rates of complete vision recovery compared with patients taking linezolid for other indications. Summary Linezolid is an effective medication for treating drug-resistant infections; however, it may result in optic neuropathy. It is reasonable for patients on linezolid to undergo screening examinations, especially those on higher doses or for prolonged duration of therapy.

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Linezolid induced optic neuropathy, a serious yet reversible adverse effect: a case report

Abstract: Background: Linezolid like many other systemic drugs can cause reversible sight threatening adverse reaction. A proper causality assessment tool can aid a decision to discontinue a drug when an adverse event is suspected.

Cited by 2 publications

References 11 publications

A Case Report and Literature Review of the Outcome of Linezolid-Induced Optic and Peripheral Neuropathy in Patients With Multidrug-Resistant Pulmonary TB

A Case Report and Literature Review of the Outcome of Linezolid-Induced Optic and Peripheral Neuropathy in Patients With Multidrug-Resistant Pulmonary TB

Linezolid optic neuropathy

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