Peripheral nervous system involvement in patients with sickle cell disease

Okuyucu, Esra; Turhanoğlu, Ayşe Dicle; Duman, Taşkın; Kaya, Helin; Melek, İsmet; Yılmazer, Selma

doi:10.1111/j.1468-1331.2009.02592.x

Cited by 20 publications

(18 citation statements)

References 24 publications

(42 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Restless legs syndrome is also a major symptom in conditions with peripheral neuropathy such as diabetes (45). Peripheral nerve involvement, diagnosed by conventional electrophysiological studies, was much more common among adult sickle cell disease individuals when compared with those without sickle cell disease (19.6 vs. 0.0%) (11). Peripheral nerve involvement may be implicated in the pathophysiology of RLS, and its diagnosis might aid in proper management of RLS in patients with sickle cell disease (46).…”

Section: Discussionmentioning

confidence: 98%

“…Because patients with sickle cell disease have low Hb concentration and some may have subclinical peripheral nerve involvement (11), they are likely to have a higher prevalence of RLS than those not having sickle cell disease. In addition, sickle cell disease is often associated with chronic and episodic painful events that can potentially increase the risk of other sleep disorders such as insomnia.…”

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Assessment of Sleep-Related Disorders in Children With Sickle Cell Disease

et al. 2014

View full text Add to dashboard Cite

Sleep-related disorders (SRDs) are common in sickle cell disease, however, identification may be time-consuming. Simultaneous survey of multiple SRDs utilizing a simplified instrument would facilitate screening. A simplified questionnaire investigating SRDs [sleep-disordered breathing (SDB), restless legs syndrome (RLS), insomnia, parasomnias, and daytime effects of disrupted sleep] was administered to 2-18-year-old children with sickle cell disease. One hundred participants completed this 5-7 minute survey without difficulties: 54 awoke unrefreshed, 41 had short-term insomnia, 30 had sleep-maintenance insomnia, 21 had chronic sleep-onset insomnia, 54 had chronic habitual snoring and 11 met the criteria for RLS. Sleep-maintenance insomnia was associated with increased body mass index (BMI) (p = 0.001), and chronic sleep-onset insomnia was associated with higher hemoglobin (Hb) levels (p = 0.04). Survey-reported symptoms of SRDs were significantly higher than that reported in the general pediatric population. A fast and simplified SRD survey is feasible and suggests a high prevalence of SRDs in children with sickle cell disease.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 98%

Assessment of Sleep-Related Disorders in Children With Sickle Cell Disease

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Adults with SCD experience complications rarely seen in childhood, including leg ulcers, end‐stage kidney disease, restrictive lung disease, pulmonary hypertension, and retinopathy . Episodic acute pain may evolve into chronic pain due to peripheral nerve injury, central sensitization, and psychosocial factors . Men with SCD experience priapism, testicular infarction, and gonadal dysfunction; women have high peripartum morbidity and mortality risks .…”

Section: Natural History Of Scdmentioning

confidence: 99%

Hematopoietic stem cell transplantation for sickle cell disease: Progress and challenges

Hulbert

Shenoy

2018

Pediatric Blood & Cancer

View full text Add to dashboard Cite

Sickle cell disease (SCD) presents challenges to hematopoietic stem cell transplantation (HSCT), including donor availability and morbidity with age/disease severity. However, severe SCD causes irreversible organ damage that HSCT can mitigate. This benefit must be balanced against preparative regimen toxicity, graft-versus-host disease, and mortality risk. We review efforts to balance HSCT complications with the promise of cure, and knowledge gaps that warrant further investigation. We highlight the burden of SCD, HSCT risks and benefits, and SCD families' approach to this balance. We emphasize the necessity for information exchange to ensure a joint decision-making process between providers and patients.

show abstract

“…Conventional electrophysiological studies of peripheral nerves were performed on all subjects [8]. Peripheral nervous system involvement was detected in 10 (19.6%) patients.…”

mentioning

confidence: 99%