Peripheral nerve regeneration through allografts compared with autografts in FK506-treated monkeys

Aubá, Cristina; Hontanilla, Bernardo; Arcocha, Juan; Gorría, Oscar

doi:10.3171/jns.2006.105.4.602

Cited by 33 publications

(30 citation statements)

References 31 publications

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“…Several techniques of peripheral nerve repair exist, including microsuturing, gluing [19, 20] and grafting [21]. Cyanoacrylate synthetic glue has therefore been proposed because its application for nerve repair is relatively easy, it maintains the anastomosis even while under tension, and it avoids all risk of viral transmission [22, 23].…”

Section: Discussionmentioning

confidence: 99%

The Role of Immediate Recurrent Laryngeal Nerve Reconstruction for Thyroid Cancer Surgery

Sanuki

Yumoto

Minoda

et al. 2010

Journal of Oncology

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Unilateral vocal fold paralysis (UVFP) is one of the most serious problems in conducting surgery for thyroid cancer. Different treatments are available for the management of UVFP including intracordal injection, type I thyroplasty, arytenoid adduction, and laryngeal reinnervations. The effects of immediate recurrent laryngeal nerve (RLN) reconstruction during thyroid cancer surgery with or without UVFP before the surgery were evaluated with videostroboscopic, aerodynamic, and perceptual analyses. All subjects experienced postoperative improvements in voice quality. Particularly, aerodynamic analysis showed that the values for all patients entered normal ranges in both patients with and without UVFP before surgery. Immediate RLN reconstruction has the potential to restore a normal or near-normal voice by returning thyroarytenoid muscle tone and bulk seen with vocal fold denervation. Immediate RLN reconstruction is an efficient and effective approach to the management of RLN resection during surgery for thyroid cancer.

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Section: Discussionmentioning

confidence: 99%

The Role of Immediate Recurrent Laryngeal Nerve Reconstruction for Thyroid Cancer Surgery

Sanuki

Yumoto

Minoda

et al. 2010

Journal of Oncology

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“…Some cases may necessitate surgical intervention 32,38,43 . There are several techniques for repairing peripheral nerves including: micro-suturing, gluing 6,18,29,32,41 (fibrin and cyanoacrylate glues), tabulation 33,36,40 , grafting 1,34 (allograft, autograft), and laser welding 15 . The ideal technique has yet to be developed, but several principles for nerve repair are accepted 5,29 .…”

mentioning

confidence: 99%

Platelet rich plasma may enhance peripheral nerve regeneration after cyanoacrylate reanastomosis: a controlled blind study on rats

Elgazzar

Mutabagani

Abdelaal

et al. 2008

International Journal of Oral and Maxillofacial Surgery

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“…Results of nerve regeneration with acellular pre-processed allografts were comparable to the current gold standard in nerve surgery [12]. …”

Section: Introductionmentioning

confidence: 97%

Characterization and Schwann Cell Seeding of up to 15.0 cm Long Spider Silk Nerve Conduits for Reconstruction of Peripheral Nerve Defects

Kornfeld

Vogt

Bucan

et al. 2016

JFB

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Nerve reconstruction of extended nerve defect injuries still remains challenging with respect to therapeutic options. The gold standard in nerve surgery is the autologous nerve graft. Due to the limitation of adequate donor nerves, surgical alternatives are needed. Nerve grafts made out of either natural or artificial materials represent this alternative. Several biomaterials are being explored and preclinical and clinical applications are ongoing. Unfortunately, nerve conduits with successful enhancement of axonal regeneration for nerve defects measuring over 4.0 cm are sparse and no conduits are available for nerve defects extending to 10.0 cm. In this study, spider silk nerve conduits seeded with Schwann cells were investigated for in vitro regeneration on defects measuring 4.0 cm, 10.0 cm and 15.0 cm in length. Schwann cells (SCs) were isolated, cultured and purified. Cell purity was determined by immunofluorescence. Nerve grafts were constructed out of spider silk from Nephila edulis and decellularized ovine vessels. Finally, spider silk implants were seeded with purified Schwann cells. Cell attachment was observed within the first hour. After 7 and 21 days of culture, immunofluorescence for viability and determination of Schwann cell proliferation and migration throughout the conduits was performed. Analyses revealed that SCs maintained viable (>95%) throughout the conduits independent of construct length. SC proliferation on the spider silk was determined from day 7 to day 21 with a proliferation index of 49.42% arithmetically averaged over all conduits. This indicates that spider silk nerve conduits represent a favorable environment for SC attachment, proliferation and distribution over a distance of least 15.0 cm in vitro. Thus spider silk nerve implants are a highly adequate biomaterial for nerve reconstruction.

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Peripheral nerve regeneration through allografts compared with autografts in FK506-treated monkeys

Cited by 33 publications

References 31 publications

The Role of Immediate Recurrent Laryngeal Nerve Reconstruction for Thyroid Cancer Surgery

The Role of Immediate Recurrent Laryngeal Nerve Reconstruction for Thyroid Cancer Surgery

Platelet rich plasma may enhance peripheral nerve regeneration after cyanoacrylate reanastomosis: a controlled blind study on rats

Characterization and Schwann Cell Seeding of up to 15.0 cm Long Spider Silk Nerve Conduits for Reconstruction of Peripheral Nerve Defects

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