Peripheral Nerve Reconstruction after Injury: A Review of Clinical and Experimental Therapies

Grinsell, Damien; Keating, Cameron

doi:10.1155/2014/698256

Cited by 735 publications

(727 citation statements)

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“…and not presenting autologous nerve graft morbidity in donor nerve removal, being able to regenerate the Sciatic nerve and thus the structures innervated 7,8 . This advantage was also reported by Demir et al 18 , who compared the use of the vein to that of a synthetic collagen tube in a 10 mm gap, and concluded that both, Tube of synthetic collagen and autologous vein grafts, produced similar results, however, with vein grafting being slightly more effective.…”

Section: ■ Discussionmentioning

confidence: 99%

“…Although this technique has a favorable result, it presents as main negative factors: the limitation of calibers, lengths and areas of donor nerves and secondary morbidity [6][7][8] . In this sense, the tubulization technique has been shown to be an appropriate and alternative method in clinical practice, which consists of the fixation of a tubular segment, which may be of biological or synthetic origin, between the stumps of the injured nerve, providing direction and favorable environment to regeneration 9,10 .…”

Section: ■ Introductionmentioning

confidence: 99%

“…In these cases the "gold standard" is autologous nerve graft, however, it has some disadvantages, such as loss of a healthy nerve, risk of neuromas formation, and limited availability of donor material 17 . Therefore, the use of autologous venous graft for nerve repair is a good option due to its low cost, non-rejection (even donor and recipient)and not presenting autologous nerve graft morbidity in donor nerve removal, being able to regenerate the Sciatic nerve and thus the structures innervated 7,8 . This advantage was also reported by Demir et al 18 , who compared the use of the vein to that of a synthetic collagen tube in a 10 mm gap, and concluded that both, Tube of synthetic collagen and autologous vein grafts, produced similar results, however, with vein grafting being slightly more effective.…”

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Comparative study between standard and inside-out vein graft techniques on sciatic nerve repair of rats. Muscular and functional analysis

et al. 2017

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Comparative study between standard and inside-out vein graft techniques on sciatic nerve repair of rats. Muscular and functional analysis 1 4-Experimental SurgeryActa Cir Bras. 2017;32(3):287-296 Abstract Purpose: To compare the functional result of standart vein grafts and inside-out vein graft technique on sciatic nerve repair. Methods: We used 24 male Wistar rats divided into 4 groups: control group (CG), standard vein graft group (SVG), Inside-out vein graft group (IOVG) and denervated Group (DG). SVG, IOVG and DG underwent total section of the sciatic nerve, SVG and IOVG however underwent nerve repair surgery using a graft with normal jugular vein and inside-out jugular vein, respectively. Histological analysis of the soleus and Extensor Digitorum Longus (EDL), and Sciatic Functional Index were used to compare the results after 6 weeks. Results: Both grafts acted favorably in muscle recovery and improved functionality; They were similar in all parameters, however, in more points SVG achieved similar to the CG, in the other hand IOVG more times was similar to DG. Fact that makes the graft with normal vein the most viable option between the two options. Conclusion: Both types of grafts acted beneficially wherein the graft normal vein has proved to be the best option 287Comparative study between standard and inside-out vein graft techniques on sciatic nerve repair of rats. Muscular and functional analysis Bueno CRS et al. Acta Cir Bras. 2017;32(3):287-296 288 For this purpose, the adhesion of the rat as an animal model was based on the fact that its physiological profile, its morphological structure and the biological processes involved in the nerve regeneration are quite similar to that of the human being, being a suitable model for this investigation 14 . The purpose of this study was to compare the muscular and functional results after sciatic nerve repair with the tubulization technique using the normal vein graft and the reverse vein graft, in order to determine the most favorable surgical option. ■ MethodsThe study was approved under the protocol 032/2011 by the Ethics Committee, Faculty of Dentistry of Bauru, Universidade de São Paulo.Were used twenty-four male Wistar rats with 60 days of life in collective storage, with no restrictions on movement, respecting cycles of 12 hours of light / dark and average ambient temperature of 24°C. The animals were divided into four groups (n=6 each). Control Group (CG) and three experimental groups: Denervate Group (DG), Inside-Out Vein Graft (IOVG) and Standart Vein Graft (SVG). In all groups the right pelvic limb was used for the experimental study. The IOVG and SVG groups received autologous venous graft from the left jugular vein, but for the IOVG group, the jugular vein was inverted. Surgical proceduresThe animals were anesthetized with a combination of Ketamine Hydrochloride (Dopalen ® ) and Xilazine Hydrochloride (Anasedan ® ), administered intramuscularly at a dose of 0.10 ml/100g body weight in the dorsolateral region of the left hind paw. Subsequen...

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Section: ■ Discussionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Comparative study between standard and inside-out vein graft techniques on sciatic nerve repair of rats. Muscular and functional analysis

et al. 2017

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“…Com relação à análise dos resultados sobre o edema, as primeiras avaliações apresentaram valores maiores que as últimas, o que pode indicar que nos primeiros dias pós-indução da lesão nervosa, os animais apresentavam mais edema, o que está de acordo com o que a literatura apresenta, visto que, segundo Grinsell e Keatin [22], o período entre 24 a 48 horas posteriores à lesão é aquele em que está ocorrendo maior acúmulo de macrófagos e células de Schwann no local da lesão, denotando um aumento do processo inflamatório local. Contudo, quando foram comparados os resultados de edema intragrupos, não foi possível observar diferença estatisticamente significativa.…”

Section: Discussionunclassified

“…Artigo originAl Antunes JS et al -Efeito do exercício resistido na redução do edema, .... Quanto à expressão de NGF e BDNF, observou-se que BDNF apresentou elevação nos grupos em que houve lesão, fato concordante com a literatura [22]. Entretanto, o grupo que recebeu exercício não foi diferente daquele apenas lesado, o que também ocorreu para o grupo sem lesão, mas com exerício.…”

Section: /9unclassified

Efeito do exercício resistido na redução do edema, nocicepção e regeneração nervosa em um modelo de compressão do nervo isquiático

Antunes¹,

Lovison²,

Karvat³

et al. 2016

Sci Med

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Este artigo está licenciado sob forma de uma licença Creative Commons Atribuição 4.0 Internacional, que permite uso irrestrito, distribuição e reprodução em qualquer meio, desde que a publicação original seja corretamente citada. ABSTRACT Aims:To analyze the effects of ladder-climbing resistance training exercise on edema, nociception, and regeneration of the sciatic nerve in Wistar rats subjected to sciatic nerve compression. Methods: Twenty-four Wistar rats were divided into four groups: Control Group, Exercise Group, Injury Group, and Treated Group (injury and exercise). Injury Group and Treated Group were subjected to sciatic nerve compression with a hemostat for 30 seconds. On the third day after injury, Exercise Group and Treated Group began treatment with ladder-climbing resistance exercise. The treatment consisted in performing two series of 10 ladder climbs with a 100-gram overload and a one-minute interval between the series. The study was conducted for 22 days, during which time the animals were evaluated for edema and nociception. Twenty-two days after surgery, the animals were anesthetized for removal of a sciatic nerve fragment and analysis of the number of axons and fiber density. Thereafter, still under anesthesia, the animals were euthanized. Nerve sampling followed the routine histological processing protocol. Expressions of Neural Growth Factor and Brain-derived Neurotrophic Factor were evaluated by Western blotting.Results: There was no significant difference in edema size between groups. Control Group showed the highest nociceptive threshold compared to the other groups. The morphometric analysis showed no significant difference in number of axons and fiber density between groups. The expression of Brain-derived Neurotrophic Factor was greater in the Injury Group and the Treated Group compared to the Control Group. Conclusions:The proposed ladder-climbing resistance training was not effective in reducing edema and nociception or in increasing the number of axons and fiber density after sciatic nerve injury.

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Bioengineered nerve conduits and wraps for peripheral nerve repair of the upper limb

Thomson

Riehle

et al. 2017

Cochrane Database of Systematic Reviews

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Peripheral Nerve Reconstruction after Injury: A Review of Clinical and Experimental Therapies

Cited by 735 publications

References 67 publications

Comparative study between standard and inside-out vein graft techniques on sciatic nerve repair of rats. Muscular and functional analysis

Comparative study between standard and inside-out vein graft techniques on sciatic nerve repair of rats. Muscular and functional analysis

Efeito do exercício resistido na redução do edema, nocicepção e regeneração nervosa em um modelo de compressão do nervo isquiático

Bioengineered nerve conduits and wraps for peripheral nerve repair of the upper limb

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