Bioengineered nerve conduits and wraps for peripheral nerve repair of the upper limb

Thomson, Sydney; Ng, Nigel Y B; Riehle, Mathis O.; Kingham, Paul J.; Dahlin, Lars B.; Wiberg, Mikael; Hart, Andrew

doi:10.1002/14651858.cd012574

Cited by 5 publications

(4 citation statements)

References 51 publications

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“…It is possible to have 3D integration or stacking of NWs based circuit (Javey et al, 2007 ) and if such work is extended for e-skin then we may see more advantages, particularly, in terms of mimicking biological tissues and brain. The integration of υ-NWFET based neural processing circuits with NW-based neural recording/mapping and stimulation circuits is another direction that could significantly advance the research in neuro-prosthetics, bio-neuro interfaces and electroceuticals (Patolsky et al, 2006 ; Qing et al, 2010 ; Robinson et al, 2013 ; Thomson et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Nanowire FET Based Neural Element for Robotic Tactile Sensing Skin

et al. 2017

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This paper presents novel Neural Nanowire Field Effect Transistors (υ-NWFETs) based hardware-implementable neural network (HNN) approach for tactile data processing in electronic skin (e-skin). The viability of Si nanowires (NWs) as the active material for υ-NWFETs in HNN is explored through modeling and demonstrated by fabricating the first device. Using υ-NWFETs to realize HNNs is an interesting approach as by printing NWs on large area flexible substrates it will be possible to develop a bendable tactile skin with distributed neural elements (for local data processing, as in biological skin) in the backplane. The modeling and simulation of υ-NWFET based devices show that the overlapping areas between individual gates and the floating gate determines the initial synaptic weights of the neural network - thus validating the working of υ-NWFETs as the building block for HNN. The simulation has been further extended to υ-NWFET based circuits and neuronal computation system and this has been validated by interfacing it with a transparent tactile skin prototype (comprising of 6 × 6 ITO based capacitive tactile sensors array) integrated on the palm of a 3D printed robotic hand. In this regard, a tactile data coding system is presented to detect touch gesture and the direction of touch. Following these simulation studies, a four-gated υ-NWFET is fabricated with Pt/Ti metal stack for gates, source and drain, Ni floating gate, and Al2O3 high-k dielectric layer. The current-voltage characteristics of fabricated υ-NWFET devices confirm the dependence of turn-off voltages on the (synaptic) weight of each gate. The presented υ-NWFET approach is promising for a neuro-robotic tactile sensory system with distributed computing as well as numerous futuristic applications such as prosthetics, and electroceuticals.

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Section: Discussionmentioning

confidence: 99%

Nanowire FET Based Neural Element for Robotic Tactile Sensing Skin

et al. 2017

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“…(1) Finger sensory function evaluation: Finger sensory recovery is divided into 5 levels according to the evaluation standard of the British Medical Research Association. [3] Grade S4: finger sensation returned to normal, 2-point resolution < 6 mm; Grade S3: recovery of finger touch and superficial sensation, and existence of 2-point discrimination; S2 grade: slight recovery of superficial sensation of fingers; S1 grade: finger skin pain recovery; Grade S0: no sensation in fingers.…”

Section: Finger Function Recoverymentioning

confidence: 99%

Practical study on the application of full-cycle fast track surgical nursing model in patients with replantation of severed fingers: A retrospective analysis

Ju,

Li,

Wang

et al. 2023

Medicine

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To explore the effect of full-cycle fast track surgical (FTS) nursing in patients with replantation of severed fingers, and observe its effect on functional recovery of replanted fingers and quality of life of patients. From January 2021 to December 2022, 86 patients with replantation of severed fingers were selected from Rizhao People’s Hospital, 41 patients were given routine perioperative care, 45 patients were given full-cycle rapid rehabilitation surgical care. Compare the relevant indexes of the 2 groups of patients during hospitalization. Three months after discharge, the finger function recovery of the 2 groups were compared, and the quality of life of the patients was scored with the QL-Index scale, and the satisfaction was evaluated at the same time. The first time of getting out of bed and the time of hospitalization in the full-cycle FTS nursing group were significantly shorter than those in the conventional nursing group, and the incidence of postoperative nausea, vomiting, constipation and venous thromboembolism were significantly lower than those in the conventional nursing group. The anxiety score was significantly lower than that in the conventional nursing group, the difference was statistically significant (P < .05). There was no significant difference in the incidence of arteriovenous crisis between the 2 groups (P > .05). Three months after discharge, the scores of finger sensation and movement, quality of life and satisfaction of patients in the FTS nursing group were higher than those in the conventional nursing group, and the difference was statistically significant (P < .05). Full-cycle fast track surgical nursing model can improve the in-patient experience, reduce the incidence of complications, promote rapid rehabilitation, improve the quality of life of patients, and improve satisfaction.

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“…In addition to biological augmentation, innovative nerve wraps and conduits are being developed to protect and support nerve regeneration following surgical decompression. These wraps provide a physical barrier, shielding the nerve from external influences and facilitating recovery [ 60 ]. Surgeons are also exploring the concept of nerve transfer in CuTS surgery.…”

Section: Reviewmentioning

confidence: 99%

From Conservative Measures to Surgical Interventions, Treatment Approaches for Cubital Tunnel Syndrome: A Comprehensive Review

Shelke,

Ambade,

Shelke

2023

Cureus

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Cubital tunnel syndrome (CuTS) is a neuropathic condition characterized by the compression or irritation of the ulnar nerve at the elbow, resulting in a wide spectrum of symptoms ranging from pain and numbness to muscle weakness and impaired hand function. This comprehensive review delves into the diverse landscape of CuTS treatment approaches, emphasizing the importance of early intervention. The review explores how these strategies aim to alleviate symptoms and enhance patient well-being by beginning with conservative measures encompassing rest, splinting, medications, physical therapy, and lifestyle adjustments. Non-surgical medical interventions, including nerve gliding exercises, ultrasound-guided nerve injections, and orthotic devices, are considered alternative therapies for symptom relief. Surgical interventions, such as decompression procedures and emerging techniques, are discussed in detail, highlighting their indications and expected outcomes. Throughout this review, the critical role of patient-centered care is underscored, emphasizing the need for tailored treatment plans that respect individual preferences and goals. Recognizing the unique nature of each CuTS case, shared decision-making between patients and healthcare providers is advocated, ensuring that interventions align with specific patient needs. As research advances, promising developments in diagnosis, surgical techniques, and drug therapies offer hope for more effective management of CuTS, paving the way for improved symptom relief and enhanced nerve function.

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Bioengineered nerve conduits and wraps for peripheral nerve repair of the upper limb

Cited by 5 publications

References 51 publications

Nanowire FET Based Neural Element for Robotic Tactile Sensing Skin

Nanowire FET Based Neural Element for Robotic Tactile Sensing Skin

Practical study on the application of full-cycle fast track surgical nursing model in patients with replantation of severed fingers: A retrospective analysis

From Conservative Measures to Surgical Interventions, Treatment Approaches for Cubital Tunnel Syndrome: A Comprehensive Review

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