“…Neutrophils are main sources of circulating angiogenetic and growth factors, which helps the tumor progression whereas lymphocytes dominate host immune response via cytotoxic cell death and cytokines production that inhibit proliferation of tumor cells (Ownby et al, 1983;Strieter et al, 2006). Lymphopenia is an independent prognostic factor for overall and progression-free survival in many cancers (Fogar et al, 2006;Ray-Coquard et al, 2009;Dou X et al, 2013).…”